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Argon to Improve Bioanalyte Stability in Fixed Tissue Specimens

Abstract: The degradation of archival surgical and biospecimen limits the utility of many biomarkers that may have prognostic or predictive significance in guiding a patient’s therapy. Previous methods at preventing the degradation of RNA and proteins in formalin fixed, paraffin embedded (FFPE) tissue blocks & slides have no protective benefit. Researchers...

Published: 5/23/2024 | Inventor(s): Stephen Hewitt, Vasuhi Rasanayagam, Joon-Yong Chung, Sagar Joshi, Meenakshi Sundar

Keywords(s): Anatomic Pathology Tissue Handling Improvements, ARGON, DNA, FFPE, formaldehyde, Formalin Fixed Paraffin Embedded, Hewitt, Paraffin Embedded, RNA

Category(s): Application > Diagnostics, TherapeuticArea > Oncology, Collaboration Sought > Licensing

Novel Fixative for Improved Biomolecule Quality from Paraffin-Embedded Tissue

Abstract: Tissues samples collected during medical procedures, such as biopsies, are used to diagnose a wide variety of diseases. Before diagnosis, patient samples are typically processed by fixation and paraffin embedding. This fixation/embedding process is used to preserve tissue morphology and histology for subsequent evaluation. Unfortunately, most...

Published: 4/8/2024 | Inventor(s): Stephen Hewitt, Candice Perry, Joon-Yong Chung, Robert Star

Keywords(s): CULTURE, fixative, Histology, PARAFFIN, PATHOLOGY, Tissue

Category(s): Collaboration Sought > Licensing, Application > Medical Devices, TherapeuticArea > Oncology, Application > Non-Medical Devices

Mitotic Figures Electronic Counting Application for Surgical Pathology

Abstract: Cancer diagnosis depends on the assessment of patient biopsies to determine tumor type, grading, and stage of malignancy. Pathologists visually review specimens and count mitotic figures (MF) in a variety of cancer types to help gauge aggressiveness, guide treatment, and inform patient prognosis. Current technology for recording MF counts...

Published: 5/23/2024 | Inventor(s): Robert Simpson, Munish Puri, Stephen Hewitt

Keywords(s): cell proliferation, COUNTING, ELECTRONIC, MATLAB, Matrix Laboratory, MF, MICROSCOPY, Mitotic Figures, PATHOLOGY, Simpson, SURGICAL

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Software / Apps, TherapeuticArea > Oncology

Ratio Based Biomarkers for the Prediction of Cancer Survival

Abstract: The AKT pathway plays a key role in the regulation of cellular survival, apoptosis, and protein translation and has been shown to have prognostic significance in a number of cancers. Recently, the inventors have identified several functions of the AKT pathway in certain cancers, such as extrahepatic cholangiocarcinoma (EHCC). The NCI seeks...

Published: 4/8/2024 | Inventor(s): Stephen Hewitt, Joon-Yong Chung, Udayan Guha

Keywords(s): AKT pathway, diagnostic, extrahepatic cholangiocarcinoma, prognostic

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Diagnostics, TherapeuticArea > Oncology

Automated Cancer Diagnostic Tool of Detecting, Quantifying and Mapping Mitotically-Active Proliferative Cells in Tumor Tissue Histopathology Whole-Slide Images

Abstract: Cancer diagnosis is based on the assessment of patient biopsies to determine the tumor type, grade, and stage of malignancy. The proliferative potential of tumors correlates to their growth and metastasis. Visually identifying and quantifying mitotic figures (MF) in cancer biopsy tissue can be used as a surrogate for proliferative activity...

Published: 5/23/2024 | Inventor(s): Robert Simpson, Stephen Hewitt, Shelley Hoover, Munish Puri

Keywords(s): Cancer Biopsy, diagnostic, Hewitt, HS, IHC, Immunohistochemistry, MF, Mitotic Figure, Mitotic Hotspots, Simpson, Tissue Histopathology

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Software / Apps

Module to Freeze and Store Frozen Tissue

Abstract: Tissue obtained for both clinical and research purposes is routinely frozen, commonly in Optimal Cutting Temperature (OCT), an embedding media, for eventual downstream analysis, commonly including sectioning on a cryostat. Though OCT is the standard compound used for freezing, there is no standard freezing protocol. Thus, current methods of...

Published: 4/8/2024 | Inventor(s): Stephen Hewitt, Jeffrey Hanson, Kristofferson Ylaya, Michael Oshetski

Keywords(s): Biopsy, Biorepository, Cryosectioning, diagnostic, Freezing, Frozen Tissue, PATHOLOGY, Storage

Category(s): Collaboration Sought > Collaboration, Application > Medical Devices, Application > Non-Medical Devices, Collaboration Sought > Licensing, TherapeuticArea > Oncology

A Specialized Tissue Collection Device for the Preservation and Transportation of Needle Biopsies

Abstract: The ability to hold and transport tissue, especially needle biopsies in a pre-defined and controlled environment is critical for the preservation of biopsy samples in downstream analytic applications. Currently, tissue specimens are placed in open containers with variable, poorly controlled solutions applied to them, often in less than sterile...

Published: 4/8/2024 | Inventor(s): Stephen Hewitt, Robert Star, Hiroshi Kijoma, Jeffrey Hanson, Armando Filie, Russell Bandle

Keywords(s): COLLECTION, DEVICE, FIXATION, Hewitt, KIDNEY, liver, LUNG, Needle Biopsy, PANCREAS, PRESERVATION, STERILE, Storage, Tissue, Transportation

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Medical Devices, Collaboration Sought > Collaboration, Application > Non-Medical Devices