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Argon to Improve Bioanalyte Stability in Fixed Tissue Specimens

Abstract: The degradation of archival surgical and biospecimen limits the utility of many biomarkers that may have prognostic or predictive significance in guiding a patient’s therapy. Previous methods at preventing the degradation of RNA and proteins in formalin fixed, paraffin embedded (FFPE) tissue blocks & slides have no protective benefit. Researchers...

Published: 5/23/2024 | Inventor(s): Stephen Hewitt, Vasuhi Rasanayagam, Joon-Yong Chung, Sagar Joshi, Meenakshi Sundar

Keywords(s): Anatomic Pathology Tissue Handling Improvements, ARGON, DNA, FFPE, formaldehyde, Formalin Fixed Paraffin Embedded, Hewitt, Paraffin Embedded, RNA

Category(s): Application > Diagnostics, TherapeuticArea > Oncology, Collaboration Sought > Licensing

DNA Methylation Based Non-invasive Blood Diagnostic Assay for Precision Cancer Detection and Classification

This technology includes a panel of 46 genomic loci of DNA methylation (represented by CpG dinucleotides on different chromosomes) with application in blood-based cancer screening. The markers robustly distinguish tumor from normal samples using 8 loci and classify 13 different tumor types. Using 39 loci, inventors were able to discriminate between...

Published: 7/25/2024 | Inventor(s): Gennady Margolin, Laura Elnitski

Keywords(s): assay, Based, Blood, CANCER, CLASSIFICATION, Detection, diagnostic, DNA, Humans, Methylation, NON-INVASIVE, PRECISION, VCXXXX, WBXXXX, WIXXXX, XEXXXX

Category(s): Application > Research Materials, Application > Diagnostics, TherapeuticArea > Oncology, Application > Therapeutics

Resurfaced Stabilized Core 3 (RSC3) Protein, Derived Proteins, and DNA Encoding These Proteins: RSC3, RSC3 delta371I, RSC3 delta371I/P363N, RSC3 G367R

Details for these materials may be found in the NIH AIDS Reagent Program Catalog – RSC3 (Catalog# 12042): https://www.aidsreagent.org/reagentdetail.cfm?t=proteins&id=214 RSC3 delta371I (Catalog# 12043): https://www.aidsreagent.org/reagentdetail.cfm?t=proteins&id=146 RSC3 delta371I/P363N (Catalog# 12362): https://www.aidsreagent.org/reagentdetail.cfm?t=proteins&id=145 RSC3...

Published: 7/25/2024 | Inventor(s): Tongqing Zhou, Gary Nabel, Zhi-yong Yang, Ling Xu, Peter Kwong

Keywords(s): 3, Core, DERIVED, DNA, Encoding, Protein, proteins, Resurfaced, RM, RSC3, Stabilized, THESE, WIXXXX

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials

Methods of Retaining Methylation Pattern Information in Globally Amplified DNA

CDC researchers have developed a novel method that generates globally amplified DNA copies retaining parental methylation information; making accurate DNA-archiving for methylation studies much more feasible and cost-effective than undertaking such an endeavor with alternate technologies. This unique approach eliminates a significant bottleneck in...

Published: 7/25/2024 | Inventor(s): Elizabeth Unger, Mangalathu Rajeevan

Keywords(s): AA5XXX, AAXXXX, AC4XXX, AC5XXX, AC6XXX, ACXXXX, AG2XXX, Amplified, AXXXXX, CC1XXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA1XXX, DA2XXX, DA3XXX, DA4AXX, DA4BXX, DA4XXX, DA5XXX, DAXXXX, DDXXXX, DNA, GAXXXX, GCXXXX, Globally, Method, Methylation, NA2BXX, NC3XXX, NC4XXX, NC5XXX, OID-NCEZID-DHCPP, Pattern, RETAINING, VAXXXX, VBXXXX, VCXXXX, VDXXXX, VEXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VJXXXX, VKXXXX, VLXXXX, VMXXXX, VNXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WFXXXX, WIXXXX, WMXXXX, XBXXXX, XCXXXX, XEXXXX, XHXXXX, YBXXXX

Real-time PCR Assay for Detection of Pneumococcal DNA and Diagnosis of Pneumococcal Disease

CDC scientists have developed a real-time PCR assay for diagnosing pneumococcal disease using amplification of the bacterial gene encoding pneumococcal surface adhesin A (PsaA). Pneumococcal isolation and identification is often complicated by 1) antimicrobial suppression of growth in culture and 2) contamination by normal flora alpha-streptococci....

Published: 7/25/2024 | Inventor(s): Edwin Ades, George Carlone, Karen McCaustland, Maria Da Gloria Carvalho, Jacquelyn Sampson

Keywords(s): assay, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, Detection, Development, Diagnosis, Disease, DNA, DXXXXX, PCR, PNEUMOCOCCAL, REAL-TIME

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Diagnostics

Methods and Composition for Identification of Variants of JC Virus DNA; An Etiologic Agent for Progressive Multifocal Leukoencephalopathy (PML)

JC Virus causes a fatal disease in the brain called progressive multifocal leukoencephalopathy (PML) that occurs in many patients with immunocompromised conditions. The finding of JCV DNA in the patients with neurological symptoms of PML is a diagnostic criterion and is needed to confirm the diagnosis of PML to rule out other neurological conditions....

Published: 7/25/2024 | Inventor(s): Caroline Ryschkewitsch, Eugene Major

Keywords(s): Chain, DA4BXX, DA4XXX, DAXXXX, DD1XXX, DDXXXX, DETECTS, DEXXXX, Distinguishes, DNA, DXXXXX, GENOTYPES, Multiplex, NON-PATHOGENIC, PATHOGENIC, polymerase, PRESENCE, REACTION, That, viral

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Infectious Disease

Human DNA Polymerase Gamma for Testing the Effect of Drugs on Mitochondrial Function

One of the primary means for treating HIV infection is the use of antiviral nucleotide or nucleoside analogs. These analogs work by inhibiting the activity of reverse transcriptase, the enzyme responsible for preparing the HIV genome for integration into the DNA of the host cell. Although these analogs do not have an effect on the polymerases responsible...

Published: 7/25/2024 | Inventor(s): Rajesh Kasiviswanathan, Susan Lim, William Copeland

Keywords(s): CLONE, DDXXXX, DEFICIENT, Directed, DNA, DXXXXX, Enzyme, EXONUCLEASE, Expression, Gamma, Human, Improved, Includes, Listed LPM Campbell as of 4/15/2015, Method, Modifications, polymerase, Polymerase., Post LPM Assignment Set 20150420, Pre LPM working set 20150418, purification, recombinant, RXXXXX, SITE, TYPE, VLXXXX, Which, Wild, WIXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics

Monoclonal Antibodies Targeting Human DNA Polymerase beta, a DNA Repair Enzyme

Available for licensing are monoclonal antibodies targeting human DNA polymerase beta (Pol B). Pol B is a constitutively expressed "housekeeping" enzyme that plays a role in base excision repair (BER), a cellular defense mechanism that repairs DNA base damage and loss. Aberrant Pol B expression is associated with genomic instability indicating that...

Published: 7/25/2024 | Inventor(s): Rajendra Prasad, Samuel Wilson

Keywords(s): AC5XXX, ACXXXX, ANTIBODY, AXXXXX, CC2XXX, CCXXXX, CDXXXX, CXXXXX, DNA, DNA polymerase, DNA polymerase beta, monoclonal, Monoclonal Antibody, monoclonal antibody based assays, polymerase

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology

Capsid-Free AAV Vectors for Gene Delivery and Their Use for Gene Therapy

The invention concerns novel capsid-free AAV vectors that can be used for gene delivery and gene therapy applications. The invention provides for a linear nucleic acid molecule comprising in this order: a first adeno-associated virus (AAV) inverted terminal repeat (ITR), a nucleotide sequence of interest, and a second AAV ITR, wherein said nucleic acid...

Published: 7/25/2024 | Inventor(s): Lina Li, Luis Garcia, Cyriaque Beley, Thomas Voit, Robert Kotin

Keywords(s): AAV, Cell, Clonal, Containing, DNA, GB2AXX, Lines, Listed LPM Reichman as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Rescueable, Sf9, STABLE, Vector, VPXXXX, WJXXXX, XEXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease

qPCR Assay for Detection of JC Virus

JC Virus causes a fatal disease in the brain called progressive multifocal leukoencephalopathy (PML) that occurs in many patients with immunocompromised conditions. For example, more than five percent (5%) of AIDS patients develop PML. Additionally, these conditions include, but are not limited to, cancers such as leukemias and lymphomas, organ transplants...

Published: 7/25/2024 | Inventor(s): Caroline Ryschkewitsch, Eugene Major

Keywords(s): assay, DA4BXX, DA4XXX, DAXXXX, DDXXXX, Detection, DEXXXX, DNA, DXXXXX, JC, Proficiency, Progressive multifocal leukoencephalopathy, QPCR, Samples', STANDARDS, Systemic lupus erythematosus, test, virus

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Infectious Disease

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