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Formulation of a Modified Stable FGF-1 (TTHX1114) to Accelerate Corneal Endothelium Regeneration

This technology includes the use of a novel formulation for an engineered version of Fibroblast Growth Factor 1 (FGF1), TTHX1114, that can be used to accelerate regeneration of the corneal endothelium after surgical lesions. FGFs are well-established regulators of migration and proliferation of corneal endothelial cells (CECs).

Published: 7/25/2024 | Inventor(s): Vinay Vyas, Hui Fang Dong, Asaf Alimardanov, Gautam ("George") Mitra, Trevor Broadt, David Eveleth

Keywords(s): FGF-1, FORMULATION, Modified, PRESERVATION, STABLE, TTHX1114, VPXXXX, WIXXXX, WKXXXX, XEXXXX

Category(s): TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, TherapeuticArea > Ophthalmology, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, Application > Research Materials, TherapeuticArea > Cardiology

Regenerative Therapy for Cartilage Damage

The subject technology discloses a tissue engineering method for treating cartilage damage. Stem cells from bone marrow are attached to a novel scaffold, hyaluronic acid-coated fibrin microbeads, and transferred to a live host to form cartilage. The regenerated cartilage is stable and not hypertrophic, which has been problematic in the current regenerative...

Published: 8/21/2024 | Inventor(s): Mitchell Shirvan, Rafael Gorodetsky, Sergei Kuznetsov, Astar Lazmi-Hailu, Pamela Robey

Keywords(s): Bone, Cartilage, Cells, Fibrin, Generation, Human, Hyaline, Marrow, Microbeads, STABLE, Stromal, TRANSPLANTATION, VAXXXX, Vivo, WJXXXX, XCXXXX, XDXXXX, YAXXXX, YBXXXX, YCXXXX

Category(s): Application > Diagnostics, Application > Research Materials, Application > Non-Medical Devices, Application > Therapeutics, TherapeuticArea > Immunology, TherapeuticArea > Geriatrics, Application > Medical Devices

Capsid-Free AAV Vectors for Gene Delivery and Their Use for Gene Therapy

The invention concerns novel capsid-free AAV vectors that can be used for gene delivery and gene therapy applications. The invention provides for a linear nucleic acid molecule comprising in this order: a first adeno-associated virus (AAV) inverted terminal repeat (ITR), a nucleotide sequence of interest, and a second AAV ITR, wherein said nucleic acid...

Published: 7/25/2024 | Inventor(s): Lina Li, Luis Garcia, Cyriaque Beley, Thomas Voit, Robert Kotin

Keywords(s): AAV, Cell, Clonal, Containing, DNA, GB2AXX, Lines, Listed LPM Reichman as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Rescueable, Sf9, STABLE, Vector, VPXXXX, WJXXXX, XEXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease

Mouse Monoclonal Antibody to the Nitrone Spin Trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO)

Oxidative stress resulting in the formation of biological radicals has been implicated in a number of human diseases, such as cancer as well as aging. There is, however, a paucity of reliable methods for in vivo or ex vivo detection of radical formation. Until now the only general technique that allowed for the detection of these highly reactive species...

Published: 7/25/2024 | Inventor(s): Marilyn (Estate of) Ehrenshaft, Ronald Mason

Keywords(s): 5, 5-dimethyl-1-pyrroline, AC5XXX, ACXXXX, ANTIBODY, AXXXXX, Detection, DMPO, ELISA, End-products, I cell disease, MBb, ML 2, ML 3 A, ML 4, monoclonal, Mouse, Mucolipidosis type 3 A, Mucolipidosis type 4, Nitrone, N-oxide, Protein, Radicals, RXXXXX, Sandwich, Specific, SPIN, STABLE, TRAP

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials

Recombinant Modified Bacillus anthracis Protective Antigen for Use in Vaccines

This invention relates to improved methods of preparing Bacillus anthracis protective antigen (PA) for use in vaccines. PA is a secreted, non-toxic protein with a molecular weight of 83 KDa. PA is a major component of the currently licensed human vaccine (Anthrax Vaccine Adsorbed, AVA). Although the licensed human vaccine has been shown to be effective...

Published: 7/25/2024 | Inventor(s): John Robbins, Stephen Leppla, Rachel Schneerson, M Rosovitz

Keywords(s): Anthrax, ANTIGEN, Chromosome 18 ring, Chymotrypsin-Sensitive, CREATION, Cutaneous anthrax, DAXXXX, DBXXXX, DC4XXX, DC6XXX, DCXXXX, DDXXXX, DELETIONS, DXXXXX, Furin-Cleavage..., Loop, MOLECULE, Protective, R 18, recombinant, rPA, STABLE, UAXXXX

Category(s): Application > Diagnostics, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines

The estrogen-related receptor alpha (ERRalpha) and proliferator-activated-receptor-gamma coactivator-1alpha (PGC-1alpha) play major roles in transcriptional control of cellular energy metabolism. In particular ERRs are required for the response to various environmental challenges that require high energy levels by the organism. As central regulators...

Published: 7/25/2024 | Inventor(s): Negin Martin, Christina Teng

Keywords(s): \Related, Cell, COACTIVATOR, ERR, estrogen, Gamma, Lines, PGC/ERR, Proliferator-activated, RECEPTOR, RELATED, -related, REPORTER, STABLE, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials