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Capsid-Free AAV Vectors for Gene Delivery and Their Use for Gene Therapy
Case ID:
TAB-3071
Web Published:
12/6/2022
Description:
The invention concerns novel capsid-free AAV vectors that can be used for gene delivery and gene therapy applications. The invention provides for a linear nucleic acid molecule comprising in this order: a first adeno-associated virus (AAV) inverted terminal repeat (ITR), a nucleotide sequence of interest, and a second AAV ITR, wherein said nucleic acid molecule is devoid of AAV capsid protein coding sequences. The said nucleic acid molecule can be applied to a host at repetition without eliciting an immune response. Methods of producing and purifying this nucleic acid molecule, as well as its use for gene transfer and gene therapy are also described.
Patent Information:
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File Date
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Direct Link:
https://nih.technologypublisher.com/tech/Capsid-Free_AAV_Vectors_for_Gene_Del ivery_and_Their_Use_for_Gene_Therapy
Category(s):
Licensing
Dental
Endocrinology
Therapeutics
Ophthalmology
Oncology
Cardiology
Infectious Disease
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For Information, Contact:
John Devany
Program Specialist
NIH Technology Transfer
301-594-4090
john.devany@nih.gov
Inventors:
Lina Li
Luis Garcia
Cyriaque Beley
Thomas Voit
Robert Kotin
Keywords:
AAV
Cell
Clonal
Containing
DNA
GB2AXX
Lines
Listed LPM Reichman as of 4/15/2015
Post LPM Assignment Set 20150420
Pre LPM working set 20150418
Rescueable
Sf9
STABLE
Vector
VPXXXX
WJXXXX
XEXXXX
YAXXXX
YBXXXX
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