Search Results - transplantation

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IL7Rα-Specific Antibody for Treating Acute Lymphoblastic Leukemia (ALL)

Abstract: Acute lymphoblastic leukemia (ALL) is the most common cancer in children with approximately 3,250 new cases occurring per year in the United States. About 20% of cases are refractory to current treatment protocols and there is a desperate need for targeted therapies that do not result in adverse side effects such as cognitive impairment. The...

Published: 4/8/2024 | Inventor(s): Scott Durum, Julie Hixon, Wenqing Li, Scotch Walsh, Lila Kashi

Keywords(s): Acute lymphoblastic leukemia (ALL), ANTIBODY, Antibody-Dependent Cellular Cytotoxicity (ADCC), Autoimmunity, CANCER, DIABETES, Durum, Interleukin-7 receptor-α (IL-7Rα), Multiple sclerosis, personalized medicine, Targeted therapy, THERAPY, TRANSPLANTATION

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration

Strategies to Protect Mammalian Neural Tissue Against Cold and Potentially Other Metabolic Stresses and Physical Damages

Abstract: Researchers at the National Eye Institute (NEI) have discovered an invention describing a composition and method(s) of using such composition for preserving viability of cells, tissues, or organs at a low temperature (around 4ºC). Current cold storage solutions or methods for cells, tissues, and organs are suboptimal due to irreversible...

Published: 12/6/2024 | Inventor(s): Jingxing Ou, Wei Li, Kiyoharu Miyagishima

Keywords(s): Cold Storage, Cold-sensitive, Hypothermia, lysosome, Mitochondria, National Eye Institute, NEI, neural injury, Ou, Protein Degradation, TRANSPLANTATION

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, Application > Research Materials, TherapeuticArea > Nephrology, TherapeuticArea > Ear, Nose, & Throat, TherapeuticArea > Ophthalmology

Regenerative Therapy for Cartilage Damage

The subject technology discloses a tissue engineering method for treating cartilage damage. Stem cells from bone marrow are attached to a novel scaffold, hyaluronic acid-coated fibrin microbeads, and transferred to a live host to form cartilage. The regenerated cartilage is stable and not hypertrophic, which has been problematic in the current regenerative...

Published: 12/26/2024 | Inventor(s): Mitchell Shirvan, Rafael Gorodetsky, Sergei Kuznetsov, Astar Lazmi-Hailu, Pamela Robey

Keywords(s): Bone, Cartilage, Cells, Fibrin, Generation, Human, Hyaline, Marrow, Microbeads, STABLE, Stromal, TRANSPLANTATION, VAXXXX, Vivo, WJXXXX, XCXXXX, XDXXXX, YAXXXX, YBXXXX, YCXXXX

Category(s): Application > Diagnostics, Application > Research Materials, Application > Non-Medical Devices, Application > Therapeutics, TherapeuticArea > Immunology, TherapeuticArea > Geriatrics, Application > Medical Devices

Methods of Inducing Immune Tolerance Using Immunotoxins

The invention concerns immunotoxins and methods of using the immunotoxins for the treatment of rejection response in a patient, including graft-versus-host disease and transplantation of organs, tissues and cells into a host. In a specific embodiment of the invention, the transplant involves pancreatic islet cells. The immunotoxins are targeted via...

Published: 10/28/2024 | Inventor(s): David Neville

Keywords(s): Activity, Agents, CB1XXX, CBXXXX, Cell, COMBINED, CXXXXX, Dendritic, Graft versus host disease, IB3XXX, IBXXXX, IMMUNE, Immunotoxin, IMMUNOTOXINS, Induce, INDUCING, INHIBIT, IN-VIVO, ISLET, IXXXXX, Maturation, Methds, Method, Methods, Novel, Pancreatic, RELATED, SUPPRESSANT, T, That, TOLERANCE, TRANSPLANTATION

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Oncology, Application > Therapeutics