Search Results - human

64 Results

Sort By:

Human and Improved Murine Monoclonal Antibodies Against CD22

Abstract: CD22 is a common cell surface glycoprotein expressed in B-cells and present in B-cell lymphomas; e.g., hairy cell leukemia (HCL), non-Hodgkins lymphoma (NHL), chronic lymphoblastic leukemia (CLL), and other cancers. It is therefore a target for cancer immunotherapy. Conjugation of anti-CD22 monoclonal antibodies with toxins or drugs has shown...

Published: 8/14/2024 | Inventor(s): Dimiter Dimitrov, Xiaodong Xiao, Ira Pastan

Keywords(s): antibodies, ANTIGEN, B-CELL, B-Cell Lymphoma, Bcl, CANCER, CD22, Chronic Lymphoblastic Leukemia, CLL, Dimitrov, Hairy cell leukemia, HCL, Human, monoclonal, NHL, non-Hodgkins lymphoma, Oncology

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

Monoclonal Antibody Against Human Alpha-5 Integrin that Does Not Disrupt Adhesive Function

This technology includes a rat monoclonal antibody termed mAb11 was generated against the human alpha-5 integrin subunit and can provide immunological characterizations without disrupting integrin adhesive function. It permits characterization of its localization even if the receptor is bound to its fibronectin ligand. The antibody is commercially available...

Published: 7/25/2024 | Inventor(s): Steven Akiyama, Susan Yamada, Kenneth Yamada

Keywords(s): Against, Alpha-5, ANTIBODY, DISRUPT, DOES, FUNCTION, Human, INTEGRIN, monoclonal, That, WIXXXX, XAXXXX

Category(s): Application > Research Materials, ResearchProducts > Antibodies, TherapeuticArea > Immunology

Longer-lived Mouse Models for Studying Gaucher Disease

The invention is a novel longer-lived mouse model for Gaucher disease. Gaucher disease is a genetic disorder that results from deficiencies in the enzyme glucocerebrosidase (GBA). The use of animal models to study how the disease progresses has been invaluable in research of this disorder. However, existing mouse models have been limited due to early...

Published: 7/25/2024 | Inventor(s): Mary Lamarca, Edward Ginns

Keywords(s): ANIMAL, DISORDERS, Gaucher, Gaucher Disease, Human, IDXXXX, Inherited, Models, RXXXXX, TRANSGENIC, VHXXXX, VPXXXX, WIXXXX, WJXXXX, WKXXXX, WMXXXX, XEXXXX

Category(s): Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Therapeutics, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology

Detecting Levels of Chymotrypsin and Amylase using Rabbit Polyclonal Antibodies Generated from Purified Human Enzymes

The invention relates to rabbit antisera raised against purified human chymotrypsin and amylase. Both chymotrypsin and amylase are produced by the pancreas and play important roles in digestion. Abnormal levels of chymotrypsin and amylase have been known to occur with multiple pancreas-related disorders, including pancreatitis. Measuring levels of these...

Published: 7/25/2024 | Inventor(s): David Jacobowitz

Keywords(s): Amylase, antibodies, Chymotrypsin, Human, Listed LPM Maddox as of 4/15/2015, polyclonal, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, rabbit, VPXXXX, WBXXXX, WIXXXX, XAXXXX

Category(s): TherapeuticArea > Immunology, Application > Research Materials, ResearchProducts > Antibodies, Application > Diagnostics, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, TherapeuticArea > Dental

Imaging Inflammation using PET Radioligands that Target Translocator Protein 18?kDa with High Affinity Regardless of Genotype

This technology includes a group of radioligands that label inflammatory cells specifically, accurately, and across different genotypes and can be detected using Positron Emission Tomography (PET). The radioligands target the Translocator protein 18 kDa (TSPO) receptor which is present on the outer mitochondrial membrane and is involved in the production...

Published: 7/25/2024 | Inventor(s): Chad Brouwer, Victor Pike

Keywords(s): 18kDa, Emission, Genotype, Human, Listed LPM Fenn as of 4/15/2015, Positron, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Quantifying/imaging, Radioligands, Regardless, tomography, TSPO, VEXXXX, VNXXXX, WBXXXX, WIXXXX, XCXXXX, XFXXXX

Category(s): Application > Research Materials, Application > Diagnostics, TherapeuticArea > Neurology, Application > Medical Devices, Application > Non-Medical Devices, Application > Software / Apps, TherapeuticArea > Psychiatry/Mental Health

Imaging Inflammation using PET Radioligands that Target Translocator Protein 18?kDa with High Affinity Regardless of Genotype

Published: 7/25/2024 | Inventor(s): Robert Innis, Federico Da Settimo, Giorgio Stefancich, Sabrina Taliani, Sabrina Castellano, Claudia Martini, Yi Zhang, Victor Pike

Keywords(s): 18kDa, Emission, Genotype, Human, Listed LPM Fenn as of 4/15/2015, NA1XXX, Positron, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Quantifying/imaging, Radioligands, Regardless, tomography, TSPO, VEXXXX, VNXXXX, WBXXXX, WIXXXX, XCXXXX, XFXXXX

Category(s): TherapeuticArea > Psychiatry/Mental Health, Application > Non-Medical Devices, TherapeuticArea > Neurology, Application > Software / Apps, Application > Diagnostics, Application > Medical Devices, Application > Research Materials

Human Fibroblast Cell Lines with PMM2 Congenital Disorder of Glycosylation for Therapeutic Development

Congenital disorders of glycosylation (CDGs) are inherited disorders of abnormal protein glycosylation that affect multiple organ systems. More than 100 different CDGs have been described, affecting protein and lipid glycosylation. NHGRI investigators have been able to isolate fibroblasts from patients with PMM2 (phosphomannomutase)-CDG, also known...

Published: 7/25/2024 | Inventor(s): Lynne Wolfe, Carlos Ferreira Lopez, William Gahl

Keywords(s): Cell, Congenital, DISORDER, Fibroblast, Glycosylatlon, Human, Lines, PMM2, VEXXXX, VPXXXX, WIXXXX, WKXXXX

Category(s): Application > Therapeutics, TherapeuticArea > Neurology, TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, TherapeuticArea > Endocrinology, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, TherapeuticArea > Dental, Application > Research Materials

Human Cell Lines with Mannosyl Oligosaccharide Glucosidase (MOGS) Defect for the Study and Prevention of Infection

This technology includes human cell lines from patients who have genetic defects in MOGS, the gene encoding mannosyl-oligosaccharide glucosidase, causing the rare congenital disorder of glycosylation type IIb, also known as MOGS-CDG. This defects appears to impair the ability of viruses to infect a second round of cells, which can be used to study and...

Published: 7/25/2024 | Inventor(s): Cynthia Tifft, Sergio Rosenzweig, David Adams, Lynne Wolfe, William Gahl

Keywords(s): Cell, Defect, GLYCOPROTEIN, Glycosidase, Human, Lines, Mannosyl, MOG, MOGS, MYELIN, Oligodendrocyte, Olygosaccharide, VLXXXX, VPXXXX, WIXXXX

Category(s): TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease, TherapeuticArea > Dental, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, Application > Research Materials

Human Cell Lines with NGLY1 Mutations for the Study of NGLY1 Deficiency and Therapeutic Development

Congenital disorders of glycosylation (CDGs) are a group of inborn errors characterized by abnormalities in the process of glycosylation of biomolecules. Although more than 100 different CDGs have been reported, only one has been thoroughly described, namely NGLY1 deficiency or NGLY1-CDG. NGLY1 encodes N-glycanase 1, an enzyme involved in the cytosolic...

Published: 7/25/2024 | Inventor(s): William Gahl, May Malicdan, Lynne Wolfe

Keywords(s): Cell, Human, Lines, Mutations, NGL, VEXXXX, WIXXXX, Y1

Category(s): Application > Research Materials, TherapeuticArea > Neurology

Staphylococcus Epidermidis Isolates from Human Skin Samples for Use as Clinical Molecular Markers

This technology includes a catalog of commensal and pathogenic staphylococci from human skin for utilization as clinical molecular markers of skin conditions and infections. The study of microbial diversity of human skin in both healthy and disease states is important to develop tools to track infections, outbreaks, and multi-drug resistant organisms,...

Published: 7/30/2024 | Inventor(s): Lilia Mijares, Heidi Kong, Julia ("Julie") Segre

Keywords(s): Epidermidis, Human, ISOLATES, SAMPLES, SKIN, Staphylococcus, VJXXXX, WBXXXX, WIXXXX, XCXXXX

Category(s): TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials

1 2 3 4 5 6 7