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A Diagnostic Kit for Assessing Exposure or Infection by the Koala Family of Retroviruses

This invention relates to a diagnostic kit for assessing exposure to or infection by a koala retrovirus. The kit consists of specific primers and probes for the detection of three distinct subtypes of infectious koala retrovirus and may be useful in various species, including humans, primates, and koalas. A family of infectious koala retroviruses are...

Published: 7/25/2024 | Inventor(s): Wenqin Xu, William Switzer, HaoQiang Zheng, Maribeth Eiden

Keywords(s): ASSESSING, CA1AXX, DA4BXX, diagnostic, Exposure, FAMILY, Gammaretroviruses, Infection, KIT, Koala, Listed LPM Maddox as of 4/15/2015, Ofgammaretroviruses, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, VCXXXX, VLXXXX, VOXXXX, WBXXXX, XCXXXX

Category(s): Application > Consumer Products, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials

Human Cell Lines with Mannosyl Oligosaccharide Glucosidase (MOGS) Defect for the Study and Prevention of Infection

This technology includes human cell lines from patients who have genetic defects in MOGS, the gene encoding mannosyl-oligosaccharide glucosidase, causing the rare congenital disorder of glycosylation type IIb, also known as MOGS-CDG. This defects appears to impair the ability of viruses to infect a second round of cells, which can be used to study and...

Published: 7/25/2024 | Inventor(s): Cynthia Tifft, Sergio Rosenzweig, David Adams, Lynne Wolfe, William Gahl

Keywords(s): Cell, Defect, GLYCOPROTEIN, Glycosidase, Human, Lines, Mannosyl, MOG, MOGS, MYELIN, Oligodendrocyte, Olygosaccharide, VLXXXX, VPXXXX, WIXXXX

Category(s): TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease, TherapeuticArea > Dental, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, Application > Research Materials

Repurposing CDK Inhibitors for the Treatment of Zika Virus Infection

This invention includes the discovery and use of a group of CDK inhibitors that were found during a drug repurposing screen designed to find compounds that inhibit Zika virus caused cell death. The identified CDK inhibitors have all previously been used in clinical trials for other diseases, potentially reducing the long time course needed for new drug...

Published: 7/25/2024 | Inventor(s): Ruili Huang, Miao Xu, Wenwei Huang, Hengli Tang, Emily Lee, Cheng YiChen, Yi Zhou, Hongjun Song, Guo-Li Ming, Zhexing Wen, Wei Zheng

Keywords(s): CDK, Infection, Inhibitors, Repurposing, treatment, VEXXXX, virus, VLXXXX, WIXXXX, WKXXXX, Zika

Category(s): TherapeuticArea > Neurology, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Research Materials

The Use of Emetine for the Treatment of SARS-CoV-2 Infection

This technology includes the clinical use of the small compound emetine for the treatment of SARS-CoV-2. Previous work has shown that emetine has antiviral properties against some DNA and RNA viruses. It is thought that the mechanism may involve blocking protein synthesis. Work has shown that emetine has potential antiviral activity in multiple tissues...

Published: 7/25/2024 | Inventor(s): Mark Henderson, Juan Marugan, Andreas Dulcey Gracia, Xin Hu, Marc Ferrer-Alegre, Noel Southall

Keywords(s): Emetine, Infection, SARS-CoV-2, treatment, VLXXXX, WIXXXX, WKXXXX

Category(s): TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Research Materials

Repurposed Use of the Alkaloids Emetine and Cephaeline to Treat Zika Virus Infection

This technology includes the use of two related compounds, Emetine and Cephaeline, as a potent inhibitor of the Zika virus (ZIKV). Emetine and it's analog Cephaeline were identified in a high-throughput assay aimed at identifying anti-ZIKV compounds. Both Emetine and Cephaeline are potent inhibitors of ZIKV infection in cell culture, and Emeline is...

Published: 7/25/2024 | Inventor(s): Emily Lee, Wei Zheng, Miao Xu, Ruili Huang, Shu Yang, Wenwei Huang, Khalida Shamim, Hao Li, Hengli Tang

Keywords(s): compounds, Emetine, Flavivirus, Infection, Prevention, treatment, VLXXXX, WIXXXX, WKXXXX

Category(s): Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Research Materials

A Novel High-Throughput Assay for Identifying Zike Virus NS2B-NS3 Protease Inhibitors

This invention includes a novel high-throughput assay to identify orthosteric inhibitors blocking the Zika virus NS2B-NS3 protease. Pathogenic flaviviruses, including Zika, require the NS2B-NS3 protease for viral replication. There is currently an unmet need for specific antiviral therapeutics against the Zika virus. Preliminary screening using the...

Published: 7/25/2024 | Inventor(s): Menghang Xia, Ruili Huang, Laura Kramer, Zhong Li, Hongmin Li

Keywords(s): Activity, Antiflaviviral, Compositions, PHARMACEUTICAL, VLXXXX, WIXXXX, WKXXXX, XHXXXX

Category(s): TherapeuticArea > Infectious Disease, Application > Therapeutics, ResearchProducts > Research Equipment, Application > Research Materials

Reducing Bloodstream Neutrophils as a Treatment for Lung Infection and Inflammation

During lung infection, bloodstream neutrophils (PMNs) responding to infection travel to the airspace lumen. Although successful arrival of microbicidal PMNs to the airspace is essential for host defense against inhaled pathogens, excessive accumulation of PMNs in the lung contributes to the pathogenesis of several prevalent lung disorders, including...

Published: 7/25/2024 | Inventor(s): Carmen Williams, Wan-Chi Lin, Michael Fessler

Keywords(s): 2, BARRIER, DA1XXX, DA3XXX, DA4XXX, DAXXXX, DBXXXX, During, DXXXXX, Epithelial, Infection, Inflammation, INTEGRITY, LUNG, MEMBRANE, PROTECT, Protein, respiratory, Targeting, VJXXXX, VKXXXX, VLXXXX, VPXXXX, WBXXXX, WJXXXX, WKXXXX, XAXXXX, YAXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, ResearchProducts > Antibodies, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, TherapeuticArea > Dental, TherapeuticArea > Immunology, TherapeuticArea > Oncology

High-Throughput COVID-19 Diagnostic Test that Detects Both Viral and Host Nucleic Acid

The rapid worldwide spread and impact of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a need for accurate, reliable, and readily accessible testing on a massive scale. NIEHS researchers developed a massively paralleled multiplexed screening method using next generation sequencing (NGS). This method uses...

Published: 7/25/2024 | Inventor(s): Brian Papa, Oswaldo Lozoya

Keywords(s): Acid, assay, DA4BXX, Diagnosis, HOST, Infection, Massively, Multi-patient, Nucleic, Paralleled, PATHOGENIC, PHYSIOLOGY, sequencing, Surveillance, VLXXXX, WBXXXX, XHXXXX, YAXXXX, YBXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment, Application > Diagnostics

RL-5 – Rabbit T Cell Line Derived From a Herpesvirus Ateles-induced Rabbit Tumor From the Inbred Rabbit Line B/J

Details for this material are provided in the NIH AIDS Reagent Program Catalog (Catalog# 341): https://www.aidsreagent.org/reagentdetail.cfm?t=cell_lines&id=152.

Published: 7/25/2024 | Inventor(s): Bishop Hague

Keywords(s): Ateles-induced, B/J., Cell, DERIVED, HERPESVIRUS, Inbred, Line, Listed LPM Ano as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, rabbit, RL-5-, RM, T, tumor, VLXXXX, WIXXXX

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Infectious Disease, Application > Research Materials

Non-invasive Method for Ebola Virus Infection Detection in Great Apes and Other Wildlife Hosts

Ebola virus surveillance in wildlife vectors of infection transmission to humans.

Published: 7/25/2024 | Inventor(s): Nancy Sullivan

Keywords(s): ACXXXX, Apes, Detection, Ebola, HOSTS, HostsNon-invasive, Humans, Infection, Method, NON-INVASIVE, Nucleoprotien, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, primate, RM, Surveillance, TRANSMISSION, vectors, virus, VLXXXX, WIXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Research Materials

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