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Reducing Bloodstream Neutrophils as a Treatment for Lung Infection and Inflammation
During lung infection, bloodstream neutrophils (PMNs) responding to infection travel to the airspace lumen. Although successful arrival of microbicidal PMNs to the airspace is essential for host defense against inhaled pathogens, excessive accumulation of PMNs in the lung contributes to the pathogenesis of several prevalent lung disorders, including...
Published: 7/25/2024   |   Inventor(s): Carmen Williams, Wan-Chi Lin, Michael Fessler
Keywords(s): 2, BARRIER, DA1XXX, DA3XXX, DA4XXX, DAXXXX, DBXXXX, During, DXXXXX, Epithelial, Infection, Inflammation, INTEGRITY, LUNG, MEMBRANE, PROTECT, Protein, respiratory, Targeting, VJXXXX, VKXXXX, VLXXXX, VPXXXX, WBXXXX, WJXXXX, WKXXXX, XAXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, ResearchProducts > Antibodies, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, TherapeuticArea > Dental, TherapeuticArea > Immunology, TherapeuticArea > Oncology
Rapid Method for the Detection of Antigen-Specific Antibodies in Any Species
Currently available identification methods for antigen-specific antibodies require live pathogens, antisera (that are only available for a limited number of species), and species-specific secondary antibodies (also a limited resource). Thus, detection or surveillance of pathogens in wild avian species or zoo animals, for example, is complex and cumbersome. Researchers...
Published: 7/25/2024   |   Inventor(s): Alison Basile
Keywords(s): antibodies, ANTIGEN-SPECIFIC, Biological, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA1XXX, DA3XXX, DA4XXX, DAXXXX, DDXXXX, Detection, Listed LPM Houze as of 4/15/2015, Method, OID-NCEZID-DVBD, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SAMPLES, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WBXXXX, WIXXXX, WMXXXX, XAXXXX, XCXXXX, XHXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, Application > Consumer Products, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, ResearchProducts > Research Equipment, Application > Diagnostics, ResearchProducts > Antibodies, Application > Research Materials
Highly Sensitive Tethered-Bead Immune Sandwich Assay
This technology is a highly sensitive tethered-bead immune sandwich assay. Analyte molecules are captured between two antibodies, a capture antibody and a detection antibody. The capture antibody on a micron-size bead binds analyte from a sample fluid. The bead-captured analyte is then exposed to a “detection” antibody that binds to the bead-captured...
Published: 7/25/2024   |   Inventor(s): Keir Neuman, Zhenyu Li, Jonathan Silver
Keywords(s): AA3AXX, assay, IMMUNE, Sandwich, TETHERED-BEAD, VCXXXX, VDXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WBXXXX, XAXXXX, XGXXXX, XHXXXX, YAXXXX, YFXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Cardiology, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology, Application > Consumer Products, TherapeuticArea > Immunology, ResearchProducts > Research Equipment, ResearchProducts > Antibodies
A Novel Virus-Based Expression System
The present invention is related to a recombinant viral vector for vaccines. Currently available poxvirus vectors for humans and other animals exhibit suboptimal expression of recombinant gene(s) and high expression of vector proteins which causes weak immunogenicity and high anti-vector immune response. The present novel virus-based expression vectors...
Published: 7/25/2024   |   Inventor(s): Linda Wyatt, Bernard Moss
Keywords(s): Expression, Gene, GENES, High, LOW, Non-Replicating, System, TARGET, vaccinia, Vector, virus, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WIXXXX, WNXXXX, XEXXXX, YAXXXX, YBXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Therapeutics
Small Molecule Imaging of Fungi by Positron Emission Tomography Scanning
This technology relates to the field of radioactive, isotopically-labeled calcofluor derivatives and uses of such compounds to detect a broad spectrum of filamentous fungi including pathogenic species such as Aspergillus and Mucorales, by diagnostic imaging methods such as positron emission tomography (PET) scanning. Aspergillosis and other filamentous...
Published: 7/25/2024   |   Inventor(s): Dale Kiesewetter, John Panepinto, Jin Qiu, Peter Williamson
Keywords(s): DA1XXX, FUNGI, IMAGING, Listed LPM Fenn as of 4/15/2015, MOLECULE, PET, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SCANNING, Small, VKXXXX, WBXXXX, XFXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Medical Devices, Application > Software / Apps, Application > Diagnostics, Application > Non-Medical Devices
Improved Acoustic Plethysmograph System for Noninvasive Measurement of Pulmonary Function
CDC researchers have developed a novel acoustic whole body plethysmograph (AWBP) that allows measurement of tidal volume in lab animals, independent of gas compression in the lung. This system provides particular advantages over the traditional whole body plethysmograph (WBP) when measuring model animals with increased gas compression due to increased...
Published: 7/25/2024   |   Inventor(s): David Frazer, Jeffrey Reynolds
Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC1XXX, AC2XXX, AC3XXX, AC6XXX, Acoustic, ACXXXX, ADXXXX, AE1BXX, AE1XXX, AE3XXX, AE4XXX, AEXXXX, ANIMAL, Animal Model, ANIMAL welfare, ASTHMA, Breath, BREATHING, CDC Docket Import, CDC Docket Import CDC Prosecuting, DDXXXX, DEVICE, DEXXXX, DXXXXX, FUNCTION, IA3XXX, IA5XXX, ICXXXX, IDXXXX, LUNG, lung cancer, Lung Disease, LUNGS, Lung-Targeted, Measuring, NIOSH, NIOSH-HELD, Plethysmograph, Pulmonary, Pulmonary edema, PULMONARY FIBROSIS, research, RESEARCH TOOL, RESPIRABLE, Respiration, respiratory, Respiratory Diseases, respiratory INFECTION, Tool, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WGXXXX, WIXXXX, WMXXXX, XDXXXX, XHXXXX, XIXXXX, XJXXXX, YCXXXX, YEXXXX, YFXXXX
Category(s): Collaboration Sought > Licensing, Application > Software / Apps, Application > Medical Devices, Application > Diagnostics, TherapeuticArea > Pulmonology, TherapeuticArea > Immunology, Application > Research Materials, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Ophthalmology, Application > Vaccines, Application > Therapeutics, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, Application > Consumer Products, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, ResearchProducts > Computational models/software, TherapeuticArea > Oncology
Focused Electrostatic Collection of Aerosol Particles for Chemical Analysis by Spectroscopic Techniques
This CDC-developed technology is an aerosol preconcentration unit (APU) designed for use with spectroscopic detection techniques, including emission, Raman, or infrared spectroscopies. Most existing pulsed microplasma techniques, such as laser-induced breakdown, for aerosols rely mainly on filter-based collection and suffer from poor accuracy, precision,...
Published: 7/25/2024   |   Inventor(s): Prasson Diwakar, Pramod Kulkarni
Keywords(s): AA2XXX, AA3AXX, AA3B5X, AA3CXX, AA3XXX, AC1XXX, AC3XXX, AC4XXX, AC6XXX, ACXXXX, ADXXXX, AE2AXX, AE2XXX, AE3XXX, AE4XXX, AEROSOL, AEXXXX, AG1XXX, ANALYSER, ANALYSES, analysis, apparatus, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DAXXXX, DEVICE, DXXXXX, IA5XXX, IDXXXX, Method, NIOSH, NIOSH-DART, OID-NCIRD-DVD, optical, PLASMA, SPECTROSCOPY, TECHNIQUE, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WEXXXX, WFXXXX, WGXXXX, WIXXXX, WMXXXX, XDXXXX, XFXXXX, XGXXXX, XHXXXX, XIXXXX, YEXXXX, YFXXXX
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Medical Devices, ResearchProducts > Research Equipment, Application > Research Materials, Application > Occupational Safety and Health, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, TherapeuticArea > Ophthalmology, Application > Consumer Products, TherapeuticArea > Oncology, TherapeuticArea > Pulmonology, Application > Non-Medical Devices, TherapeuticArea > Infectious Disease, Application > Software / Apps, TherapeuticArea > Cardiology
Simple, Field-Usable Fluorescence-Based Isothermal LAMP Assay for the On-Site Diagnosis of Malaria
CDC researchers have developed improved Loop-Mediated Isothermal Amplification (LAMP) assays for the nucleic acid-based diagnosis of malaria in field settings. The approach employs Plasmodium genus-specific LAMP primers and a portable tube scanner to run the LAMP reaction and measure fluorescence signal (e.g., SYBR green) as a measure of DNA amplification...
Published: 7/25/2024   |   Inventor(s): Allison Demas, Naomi Lucchi, Venkatachalam Udhayakumar
Keywords(s): assay, Based, CDC Docket Import, CDC Docket Import CDC Prosecuting, CDCRM, DA2XXX, DAXXXX, DDXXXX, DEVELOPING, Development, Diagnosis, diagnostic, DXXXXX, Field-usable, Fluorescence, Isothermal, ivd, LAMP, LIMITED-RESOURCE, LOW INPUT, Malaria, Mosquito, Mosquitoes, nucleic acid, NUCLEIC ACID DETECTION, PCR ALTERNATIVE, real time, REAL-TIME, SIMPLE, travel, traveler, travelers, VBXXXX, Vector-borne, Vector-borne diseases, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WBXXXX, WDXXXX, WFXXXX, WIXXXX, WMXXXX, YBXXXX, Zoonotic
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Occupational Safety and Health, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Consumer Products
Methods for Near Real-time Chemical Analysis of Aerosols using Microwave-induced Plasma Spectroscopy
This CDC developed technology entails a novel method of near real-time elemental analysis of aerosols by corona assisted microwave induced plasma spectroscopy (CAMPS). Analysis of elemental composition of aerosol particles holds significant implications for environmental and workplace pollution monitoring. Various plasma based analytical techniques,...
Published: 7/25/2024   |   Inventor(s): Philip Efthimion, Pramod Kulkarni
Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, Microelectrode-Assisted, Microwave-Induced, NIOSH-DART, PLASMA, SPECTROSCOPY, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WEXXXX, WFXXXX, WGXXXX, WHXXXX, WIXXXX, WMXXXX, XDXXXX, XHXXXX, XIXXXX, YEXXXX, YFXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, TherapeuticArea > Dental, Application > Consumer Products, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment, Application > Non-Medical Devices, Application > Medical Devices, Application > Occupational Safety and Health, Application > Research Materials, TherapeuticArea > Cardiology, TherapeuticArea > Endocrinology, Application > Vaccines, TherapeuticArea > Ophthalmology, Application > Therapeutics, Application > Diagnostics
Human iPSC-Derived Mesodermal Precursor Cells and Differentiated Cells
Cells, cell culture methods, and cell culture media compositions useful for producing and maintaining iPSC-derived cell lines that are of higher purity and maintain cell type integrity better than current iPSC-derived cell lines are disclosed. Human induced pluripotent stem cells (hiPSCs) can be generated by reprogramming somatic cells by the expression...
Published: 7/25/2024   |   Inventor(s): Guibin Chen, Mahendra Rao, Andre Larochelle, Manfred Boehm
Keywords(s): Cells, Hematopoetic, Human, IB6XXX, IDXXXX, IPSC-derived, Screenings, THERAPIES, Toxicology/drug, Vascular-related, VAXXXX, VBXXXX, VCXXXX, VDXXXX, VEXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VJXXXX, VKXXXX, VLXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WGXXXX, WHXXXX, WIXXXX, WJXXXX, WKXXXX, WMXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, Application > Occupational Safety and Health, Application > Diagnostics, TherapeuticArea > Cardiology, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Endocrinology, Application > Consumer Products, Application > Vaccines, TherapeuticArea > Dental, TherapeuticArea > Ophthalmology, TherapeuticArea > Immunology, TherapeuticArea > Neurology, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, TherapeuticArea > Reproductive Health, TherapeuticArea > Geriatrics
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