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Multiplexing Homocysteine in Primary Newborn Screening Assays Using Maleimides as Select Derivatization Agents

Homocystinuria (HCU), a group of inherited disorders, causes symptoms ranging from failure to thrive and developmental delays in infants or young children to abnormal blood clots with onset in adults.1 Approximately 1 in 200,000 to 335,000 people have HCU globally.2 Various clinical settings use the dried blood spot (DBS) for sample collection methods...

Published: 7/25/2024 | Inventor(s): Charles Pickens, Konstantinos Petritis

Keywords(s): 4AXXXX, Agents, ASSAYS, Derivatization, Hcy, HOMOCYSTEINE, Maleimides, Multiplexing, Newborn, Primary, screening, SELECTIVE, VDXXXX, VPXXXX, WFXXXX, WHXXXX, WIXXXX, XCXXXX, XHXXXX, YAXXXX, YDXXXX, YFXXXX

Category(s): TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, TherapeuticArea > Ophthalmology, Application > Consumer Products, TherapeuticArea > Dental, Application > Research Materials, ResearchProducts > Research Equipment, Application > Occupational Safety and Health, Application > Diagnostics

Gene Therapy for Cobalamin C Deficiency (cblC) with Viable Mouse Models

Cobalamin C deficiency (cblC) is the most common inborn error of intracellular cobalamin metabolism and is caused by mutations in MMACHC, a gene responsible for processing and trafficking dependent enzymes: intracellular cobalamin, resulting in elevated methylmalonic acid and homocysteine and methionine deficiency. Disease manifestations include growth...

Published: 7/25/2024 | Inventor(s): Jennifer Sloan, Charles Venditti

Keywords(s): C, cblC, Cobalamin, DEFICIENCY, Gene, THERAPY, VDXXXX, VEXXXX, VPXXXX, WIXXXX, WJXXXX, XEXXXX

Category(s): TherapeuticArea > Dental, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, TherapeuticArea > Neurology, TherapeuticArea > Infectious Disease, Application > Research Materials

Creation and Use of 12-LO inhibitors (4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives) for the Treatment of Diabetes and Large Platelet-Derived Clots

This technology includes the discovery and use of novel selective 12-LO (lipoxygenase) inhibitors, 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives, for attenuating large clots and for the treatment of Type 1/2 diabetes. A 12-LO inhibitor could be a potent intracellular approach to block platelets from forming large clots in response...

Published: 7/25/2024 | Inventor(s): Ajit Jadhav, Anton Simeonov, Adam Yasgar, Diane Luci, Michael Holinstat, Theodore Holman, Jerry Nadler, David Taylor-Fishwick, David Maloney

Keywords(s): 12-Lipoxygenase., 4-2-hydroxy-3-methoxybenzylaminobenzenesulfon, Derivatives, Discovery, Human, Inhibitors, Listed LPM Nguyen-Antczak as of 4/15/2015, Post LPM Assignment Set 20150420, POTENT, Pre LPM working set 20150418, SELECTIVE, VDXXXX, VFXXXX, WKXXXX, XEXXXX

Category(s): TherapeuticArea > Cardiology, TherapeuticArea > Endocrinology, Application > Therapeutics

A Novel Reagent for Labeling PET Tracers at Trifluoromethyl Groups

The molecular imaging technique of positron emission tomography (PET) is an increasingly important tool in biomedical research and in drug discovery and development. Many small molecule drugs and potential PET radiotracers carry trifluoromethyl (CF3) groups. Because CF3 groups are generally considered to be metabolically stable, there is a strong interest...

Published: 7/25/2024 | Inventor(s): Mohammad Haskali, Victor Pike

Keywords(s): :, [11C]Fluoroalkanes, Added, AGENT, LABELING, Method, No-Carrier, PET, Producing, Radiotracers, VAXXXX, VCXXXX, VDXXXX, VEXXXX, VNXXXX, WBXXXX, WIXXXX, XDXXXX, XFXXXX, YAXXXX, YBXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Geriatrics, Application > Software / Apps, TherapeuticArea > Psychiatry/Mental Health, TherapeuticArea > Neurology, Application > Medical Devices, TherapeuticArea > Immunology

Inner Curvature Charge Concentration Device for Tissue Laceration

Left ventricular outflow tract obstruction is a life-threatening complication of transcatheter mitral valve replacement caused by septal displacement of the anterior mitral leaflet (AML). The AML is a mobile structure that physically separates inflow and outflow zones of the left ventricle. Preserving the AML during surgical mitral valve replacement...

Published: 7/25/2024 | Inventor(s): Jaffar Khan, Toby Rogers, Robert Lederman

Keywords(s): AB2XXX, AB3GXX, BASILICA, Curvature, Laceration, Leaflet, LEAFLETS, Trans-auricular, VDXXXX, XDXXXX

Category(s): Collaboration Sought > Collaboration, Application > Medical Devices, Application > Non-Medical Devices, TherapeuticArea > Cardiology

Highly Sensitive Tethered-Bead Immune Sandwich Assay

This technology is a highly sensitive tethered-bead immune sandwich assay. Analyte molecules are captured between two antibodies, a capture antibody and a detection antibody. The capture antibody on a micron-size bead binds analyte from a sample fluid. The bead-captured analyte is then exposed to a “detection” antibody that binds to the bead-captured...

Published: 7/25/2024 | Inventor(s): Keir Neuman, Zhenyu Li, Jonathan Silver

Keywords(s): AA3AXX, assay, IMMUNE, Sandwich, TETHERED-BEAD, VCXXXX, VDXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WBXXXX, XAXXXX, XGXXXX, XHXXXX, YAXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Cardiology, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology, Application > Consumer Products, TherapeuticArea > Immunology, ResearchProducts > Research Equipment, ResearchProducts > Antibodies

Octopod (8-Pointed Star) Iron Oxide Nanoparticles Enhance MRI T2 Contrast

The octopod-shaped iron oxide nanoparticles of this technology significantly enhance contrast in MRI imaging compared to spherical superparamagnetic iron oxide nanoparticle T2 contrast agents. These octopod iron oxide nanoparticles show a transverse relaxivity that is over five times greater than comparable spherical agents. Because the unique octopod...

Published: 7/25/2024 | Inventor(s): Jinhao Gao, Zhenghuan Zhao, Xiaoyuan (Shawn) Chen

Keywords(s): Agents, CA2CXX, Contrast, High-Performance, IMAGING, IRON, Magnetic, Nanoparticles, Non-spherical, OXIDE, PXXXXX, Resonance, T2, VCXXXX, VDXXXX, WBXXXX, XFXXXX, XGXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Cardiology, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Oncology, Application > Software / Apps, Application > Non-Medical Devices, Application > Medical Devices

A Novel X-ray Grating to Enhance Phase Contrast Imaging

The present invention relates to improving x-ray phase contrast imaging. The invention discloses a novel grating interferometer for phase contrast imaging with hard x-rays that overcomes limitations in the level of sensitivity by utilizing the advantages of far-field interferometers. The novel design and fabrication process can easily acquire absolute...

Published: 7/25/2024 | Inventor(s): Han Wen

Keywords(s): AA3XXX, Balanced, GRATING, INTERFEROMETER, Two-arm, VCXXXX, VDXXXX, WBXXXX, WIXXXX, XDXXXX, XFXXXX, X-RAY, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, Application > Software / Apps, Application > Medical Devices, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Oncology

A Novel Demodulation System in X-ray Imaging

In various x-ray imaging methods, including scattering correction and phase contrast imaging, intensity modulation in space is introduced into the projection images by the use of masks, gratings, or apertures. The present invention relates to a process to demodulate the modulation. The current demodulation processes are either to remove the modulation...

Published: 7/25/2024 | Inventor(s): Houxun Miao, Han Wen

Keywords(s): AA3XXX, Demodulation, IMAGING, INTENSITY, Modulation, VCXXXX, VDXXXX, VEXXXX, VPXXXX, WBXXXX, WIXXXX, XDXXXX, XFXXXX, X-RAY, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Ophthalmology, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, Application > Software / Apps, TherapeuticArea > Neurology, Application > Research Materials, Application > Diagnostics, Application > Medical Devices

Treatment of Chronic Kidney Disease with Synthetic Amphipathic Peptides

The invention is directed to treatment of chronic kidney disease by administering a synthetic, amphipathic helical peptide known as 5A-37pA, and novel derivatives thereof. Scientists at NIDDK have demonstrated that invention peptides antagonize activity of a particular scavenger receptor known as CD36. Using an in vivo model, NIDDK scientists have shown...

Published: 7/25/2024 | Inventor(s): Peter Yuen, Robert Star, Alexander Bocharov, Alan Remaley, Thomas Eggerman, Ana Souza

Keywords(s): 5A-37pA, AMPHIPATHIC, Chronic, Disease, HELICAL, KIDNEY, Peptide, treatment, VDXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VPXXXX, WIXXXX, WJXXXX, XHXXXX, YAXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Oncology, ResearchProducts > Research Equipment, Application > Research Materials

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