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Creation and Use of 12-LO inhibitors (4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives) for the Treatment of Diabetes and Large Platelet-Derived Clots
Case ID:
TAB-3606
Web Published:
12/6/2022
Description:
This technology includes the discovery and use of novel selective 12-LO (lipoxygenase) inhibitors, 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives, for attenuating large clots and for the treatment of Type 1/2 diabetes. A 12-LO inhibitor could be a potent intracellular approach to block platelets from forming large clots in response to vessel injury or activation of the coagulation pathway, either due to diabetes and/or cardiovascular disease. Blocking clot formation can significantly decrease the occurrence of myocardial infarction and death.
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Direct Link:
https://nih.technologypublisher.com/tech/Creation_and_Use_of_12-LO_inhibitors _(4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide_derivatives)_for_th e_Treatment_of_Diabetes_and_Large_Platelet-Derived_Clots
Category(s):
Cardiology
Endocrinology
Therapeutics
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For Information, Contact:
Suryanarayana Vepa
Technology Licensing Specialist
NIH Technology Transfer
301-827-7181
sury.vepa@nih.gov
Inventors:
Ajit Jadhav
Anton Simeonov
Adam Yasgar
Diane Luci
Michael Holinstat
Theodore Holman
Jerry Nadler
David Taylor-Fishwick
David Maloney
Keywords:
12-Lipoxygenase.
4-2-hydroxy-3-methoxybenzylaminobenzenesulfon
Derivatives
Discovery
Human
Inhibitors
Listed LPM Nguyen-Antczak as of 4/15/2015
Post LPM Assignment Set 20150420
POTENT
Pre LPM working set 20150418
SELECTIVE
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VFXXXX
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