Search Results - alan+remaley

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Immunogens, Compositions, and Methods for the Treatment of Dyslipidemia

This technology includes a novel vaccine for forming autoantibodies against apoC-III, a plasma enzyme that inhibits lipolysis. The vaccine can possibly be used to treat patients with high triglycerides and are at risk for pancreatitis and cardiovascular disease. This disclosure describes an ApoC3 immunogen that includes an antigenicApoC3 peptide linked...

Published: 8/12/2024 | Inventor(s): Alan Remaley

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, Application > Vaccines, Collaboration Sought > Licensing, ResearchProducts > Antibodies, TherapeuticArea > Metabolic Disease

Novel ApoC-11 Mimetic Peptides That Activate LPL for the Treatment of ApoC-11 Deficiency and Hypertriglyceridemia

This technology includes a new class of synthetic peptides that activate Lipoprotein Lipase (LPL), a key plasma enzyme that lowers triglycerides. Mutations in apoC-II is a genetic cause of severe hypertriglyceridemia, which can lead to cardiovascular disease and pancreatitis. The last helical domain (3rd helix) of apoC-ll activates LPL, and we discovered...

Published: 9/11/2024 | Inventor(s): Soumitra Ghosh, Chih-Hung (Larry) Lo, Alan Remaley, Denis Sviridov, Anna Wolska

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Cardiology

Methods to Produce Very Long Chain Fatty Acids (VLCFA) for Use as Nutritional Formulas and as Therapeutics for Disease

This technology includes a new method to prepare very long chain fatty acids (VLCFA), which does not use the previously reported toxic mercury amalgam, for use as nutritional supplements, and as therapeutics for various diseases. The key coupling step involves an organocopper mediated coupling of the Grignard regent derived from the bromo alkyl tetraene...

Published: 9/11/2024 | Inventor(s): Rolf Swenson, Zhen-Dan Shi, Zhihong Yang, Alan Remaley

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Licensing

ApoE-ApoCII Chimeric Peptides for Treating Hypertriglyceridemia

This technology includes apoE-apoCII chimeric peptides that possess the ability to lower the triglyceride level both in vitro and in vivo. These peptides can be used for treating hypertriglyceridemia and alleviating other diseases and conditions associated with increased triglycerides.

Published: 9/11/2024 | Inventor(s): Soumitra Ghosh, Chih-Hung (Larry) Lo, Alan Remaley, Denis Sviridov, Anna Wolska, Madhav (Matt) Devalaraja

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Cardiology

Compositions and Methods for Reducing Serum Triglycerides

This technology includes a vaccine for lowering plasma triglycerides by inducing the formation of autoantibodies against either ANGPTL3 or ANGPTL4, which are inhibitors of Lipoprotein Lipase. This was done by conjugating synthetic peptides based on ANGPTL3 or ANGPTL4 to virus- like particles (VLPS). Injection of the vaccine in animal models was shown...

Published: 9/11/2024 | Inventor(s): Alexandra Fowler, Alan Remaley, Marcelo Amar, Bryce Chackerian

Keywords(s):

Category(s): Application > Therapeutics, Application > Research Materials, Application > Vaccines, Collaboration Sought > Licensing, TherapeuticArea > Cardiology

High Density Lipoprotein Targeting Protease Inhibitor Peptide for the Treatment of Alpha-1-antitrypsin (A1AT) Deficiency

This technology includes a novel concept and design for a lipoprotein targeting protease inhibitor for the treatment of Alpha-1-antitrypsin (A1AT) deficiency. A1AT deficiency occurs in about 1 in 2500 individuals in the United States and Europe, and people with this condition develop severe liver disease and emphysema/chronic obstructive pulmonary disease...

Published: 9/11/2024 | Inventor(s): Alan Remaley, Scott Gordon

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Respiratory

Anti-sense Therapy Against ApoC-III as a Treatment for High Cholesterol

This technology includes a new class of synthetic peptides that activate Lipoprotein Lipase (LPL), a key plasma enzyme that lowers triglycerides, by displacing apoC-111, a potent inhibitor of LPL. ApoC-11 is a known activator of LPL, whereas ApoC-111 inhibits LPL and raises triglycerides either directly by blocking lipolysis and or by preventing hepatic...

Published: 9/11/2024 | Inventor(s): Soumitra Ghosh, Chih-Hung (Larry) Lo, Alan Remaley, Madhav (Matt) Devalaraja, Denis Sviridov, Anna Wolska

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Cardiology

Cycioxygenase-2 Inhibition for the Treatment-SAA-high Asthma

This technology includes the use of cyclooxygenase-2 (COX-2) inhibitors for the treatment of serum amyloid A (SAA)-high asthma. A commercially available enzyme-linked immunosorbent assay was used to analyze serum levels of SAA in a cohort of 154 non-asthmatic subjects to establish the upper 95th centile value of serum SAA in healthy individuals as >...

Published: 9/11/2024 | Inventor(s): Stewart Levine, Xianglan Yao, Alan Remaley, Amisha Barochia, Maryann Kaler

Keywords(s):

Category(s): Application > Diagnostics, Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Immunology, TherapeuticArea > Respiratory

Treatment of Chronic Kidney Disease with Synthetic Amphipathic Peptides

The invention is directed to treatment of chronic kidney disease by administering a synthetic, amphipathic helical peptide known as 5A-37pA, and novel derivatives thereof. Scientists at NIDDK have demonstrated that invention peptides antagonize activity of a particular scavenger receptor known as CD36. Using an in vivo model, NIDDK scientists have shown...

Published: 7/25/2024 | Inventor(s): Peter Yuen, Robert Star, Alexander Bocharov, Alan Remaley, Thomas Eggerman, Ana Souza

Keywords(s): 5A-37pA, AMPHIPATHIC, Chronic, Disease, HELICAL, KIDNEY, Peptide, treatment, VDXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VPXXXX, WIXXXX, WJXXXX, XHXXXX, YAXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Oncology, ResearchProducts > Research Equipment, Application > Research Materials

Stapled Peptides for Treatment of Cardiovascular Diseases and Inflammation

The invention is directed to small molecule mimetics of apolipoproteins that have an inter-helical hydrocarbon bond, which stabilizes helix formation. Apolipoproteins facilitate the transport of lipids and cholesterol in the body. Mimetics of apolipoproteins have been used to treat cholesterol-related disorders. However, these mimetics are susceptible...

Published: 4/8/2024 | Inventor(s): Marcelo Amar, Imoh Ikpot, Denis Sviridov, David Osei-Hwedieh, Alan Remaley

Keywords(s): Acylation, ALKYLATION, AMPHIPATHIC, Biological, IB1CXX, IB1DXX, IB1EXX, IB1FXX, IB1XXX, IBXXXX, IXXXXX, Peptides, PROPERTIES, Their, therapeutic

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Diagnostics, TherapeuticArea > Cardiology, Application > Research Materials

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