Search Results - ib1dxx

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Stapled Peptides for Treatment of Cardiovascular Diseases and Inflammation

The invention is directed to small molecule mimetics of apolipoproteins that have an inter-helical hydrocarbon bond, which stabilizes helix formation. Apolipoproteins facilitate the transport of lipids and cholesterol in the body. Mimetics of apolipoproteins have been used to treat cholesterol-related disorders. However, these mimetics are susceptible...

Published: 4/8/2024 | Inventor(s): Marcelo Amar, Imoh Ikpot, Denis Sviridov, David Osei-Hwedieh, Alan Remaley

Keywords(s): Acylation, ALKYLATION, AMPHIPATHIC, Biological, IB1CXX, IB1DXX, IB1EXX, IB1FXX, IB1XXX, IBXXXX, IXXXXX, Peptides, PROPERTIES, Their, therapeutic

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Diagnostics, TherapeuticArea > Cardiology, Application > Research Materials

PTH2 and PTH1 Receptor Ligands

Parathyroid hormone receptors found on osteoblasts in bone and renal tubule cells in kidney elevate blood calcium levels when stimulated by parathyroid hormone (PTH) and PTH-related protein (PTHrP). Excessive secretion of PTH from the parathyroid gland results in primary hyperparathyroidism. Production of PTHrP by various tumors results in humoral...

Published: 7/25/2024 | Inventor(s): Ted Usdin, Samuel Hoare

Keywords(s): Chromosome 7, monosomy, Deletion 7, IAXXXX, IB1DXX, IBXXXX, IXXXXX, NB1DXX, NBXXXX, NXXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Neurology, Application > Research Materials, TherapeuticArea > Cardiology, Application > Therapeutics