Search Results - marcelo+amar

4 Results

Sort By:

Compositions and Methods for Reducing Serum Triglycerides

This technology includes a vaccine for lowering plasma triglycerides by inducing the formation of autoantibodies against either ANGPTL3 or ANGPTL4, which are inhibitors of Lipoprotein Lipase. This was done by conjugating synthetic peptides based on ANGPTL3 or ANGPTL4 to virus- like particles (VLPS). Injection of the vaccine in animal models was shown...

Published: 9/11/2024 | Inventor(s): Alexandra Fowler, Alan Remaley, Marcelo Amar, Bryce Chackerian

Keywords(s):

Category(s): Application > Therapeutics, Application > Research Materials, Application > Vaccines, Collaboration Sought > Licensing, TherapeuticArea > Cardiology

Stapled Peptides for Treatment of Cardiovascular Diseases and Inflammation

The invention is directed to small molecule mimetics of apolipoproteins that have an inter-helical hydrocarbon bond, which stabilizes helix formation. Apolipoproteins facilitate the transport of lipids and cholesterol in the body. Mimetics of apolipoproteins have been used to treat cholesterol-related disorders. However, these mimetics are susceptible...

Published: 4/8/2024 | Inventor(s): Marcelo Amar, Imoh Ikpot, Denis Sviridov, David Osei-Hwedieh, Alan Remaley

Keywords(s): Acylation, ALKYLATION, AMPHIPATHIC, Biological, IB1CXX, IB1DXX, IB1EXX, IB1FXX, IB1XXX, IBXXXX, IXXXXX, Peptides, PROPERTIES, Their, therapeutic

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Diagnostics, TherapeuticArea > Cardiology, Application > Research Materials

Therapeutic Peptide Treatment for Dyslipidemic and Vascular Disorders

This invention is directed to use of certain peptide analogs comprising multiple amphipathic helical domains that are able to promote cellular lipid efflux and stimulate lipoprotein lipase activity. As a result, administration of invention peptides lead to reduced incidences of hypertriglyceridemia without inducing toxicity. Existing peptides that stimulate...

Published: 7/25/2024 | Inventor(s): Marcelo Amar, Alan Remaley

Keywords(s): 3-@hydroxyacyl-coa dehydrogenase deficiency, ApoA-I, HAD deficiency, HIS deficiency, Histidinemia, Hypertriglyceridemia, IB1XXX, IBXXXX, IXXXXX, Mimetic, Patent Category - Biotechnology, Peptides, VDXXXX, VHXXXX, WBXXXX, WJXXXX, YAXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Endocrinology, TherapeuticArea > Cardiology, Application > Diagnostics, Application > Research Materials

ApoA-1 Mimetic Peptides Promoting Lipid Efflux from Cells for Treatment of Vascular Disorders

This invention involves ApoA-1 mimetic peptides with multiple amphipathic alpha-helical domains that promote lipid efflux from cells and are useful in the treatment and prevention of dyslipidemic, inflammatory and vascular disorders. IND-enabling studies for one of the peptides, named Fx-5A, are completed in preparation for an IND filing at the FDA,...

Published: 7/25/2024 | Inventor(s): Edward Neufeld, Fairwell Thomas, H. Bryan Brewer, Stephen Demosky, John Stonik, Marcelo Amar, Alan Remaley

Keywords(s): (4)r syndrome, 3-@hydroxyacyl-coa dehydrogenase deficiency, AMPHIPATHIC, assay, Atherosclerosis., C syndrome, Chromosome 4 ring syndrome, Chromosome 6 ring syndrome, Chromosome 7 ring syndrome, COMPOSITION, G syndrome, HAD deficiency, HELICAL, HIS deficiency, Histidinemia, Hyperlipoproteinemia, Hypertelorism with esophageal abnormality and hypospadias, IA1XXX, IAXXXX, IXXXXX, Listed LPM Nguyen-Antczak as of 4/15/2015, Multi-domain, N syndrome, Patent Category - Biotechnology, Peptides, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, R(6) syndrome, R(7) syndrome, Syndrome X, System, treatment, UA1XXX, VDXXXX, VHXXXX, W syndrome, W syndrome; Syndrome W, WJXXXX, YAXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, Application > Diagnostics