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A Genetic System in Yeast for Functional Identification of Human p53 Mutations

Mutations in the p53 gene are associated with 50% of all cancers and nearly 80% of the p53 mutations are missense changes. We have developed genetic assays based in yeast that can functionally categorize expressed p53 mutant proteins. The combined assays are referred to as the FIP53 system. Because human p53 cDNA can be conveniently cloned in yeast,...

Published: 7/25/2024 | Inventor(s): Alberto Inga, Michael Resnick

Keywords(s): CA1XXX, CAXXXX, FUNCTIONAL, GAXXXX, Genetic, Human, Identification, Listed LPM Wong as of 4/15/2015, Mutations, p53, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SACGHS DNA Patent Initial Set, System, X, Yeast

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics, Application > Therapeutics

A Novel Virus-Based Expression System

The present invention is related to a recombinant viral vector for vaccines. Currently available poxvirus vectors for humans and other animals exhibit suboptimal expression of recombinant gene(s) and high expression of vector proteins which causes weak immunogenicity and high anti-vector immune response. The present novel virus-based expression vectors...

Published: 7/25/2024 | Inventor(s): Linda Wyatt, Bernard Moss

Keywords(s): Expression, Gene, GENES, High, LOW, Non-Replicating, System, TARGET, vaccinia, Vector, virus, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WIXXXX, WNXXXX, XEXXXX, YAXXXX, YBXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Therapeutics

Occupational Safety: Portable Exposure Assessment System for Prevention of Musculoskeletal Injury

CDC researchers have developed the Portable Exposure Assessment System (PEAS), a field-based, remotely deployed tool to monitor and provide early warning of working conditions that have a high likelihood of musculoskeletal injury. PEAS is a noninvasive, real-time, instrument-based system. Sensor technology simultaneously measures and collects data...

Published: 7/25/2024 | Inventor(s): Bryan Wimer, Shengke Zeng, Christopher Pan

Keywords(s): AA1XXX, AA4XXX, AAXXXX, AE1BXX, AE1CXX, AE1XXX, AE2AXX, AE2BXX, AE2XXX, AE3XXX, AE4XXX, AEXXXX, AFXXXX, AG3XXX, AGXXXX, apparatus, ASSESSING, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Conditions, Injured, Injuries, INJURY, LEAD, Likely, lumbar, Method, MOBILE, MOBILES, MUSCLE, Muscles, MUSCULAR, musculoskeletal, NIOSH, NIOSH-DSR, Occupational health, PERSONAL, Personalized, Portable, SAFE, Safely, SAFETY, System, VMXXXX, VPXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, WMXXXX, WORKER, WORKER safety, WORKERS, XDXXXX, XHXXXX, XIXXXX, XJXXXX, YAXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, ResearchProducts > Research Equipment, Application > Software / Apps, Application > Medical Devices, Application > Diagnostics, TherapeuticArea > Neurology, Application > Research Materials, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, ResearchProducts > Computational models/software, Application > Non-Medical Devices, Application > Occupational Safety and Health, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease, Application > Consumer Products, TherapeuticArea > Dental, TherapeuticArea > Oncology

Hearing Safety Devices: System for Monitoring Exposure to Impulse Noise

This CDC-developed technology entails a system for monitoring and assessing the risk of auditory damage from exposure to impulse noise, such as noise created by construction machinery and firearms. Noise dosimeters have been used extensively over the past two decades to document personal exposure to noise and assure workplaces comply with permissible...

Published: 7/25/2024 | Inventor(s): Chucri Kardous

Keywords(s): AA5XXX, AAXXXX, AC1XXX, AC2XXX, ADXXXX, AE1BXX, AE1XXX, AE2BXX, AE2XXX, AE3XXX, AEXXXX, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Exposure, firearm, firearm safety, IMPULSE, MONITORING, NIOSH, NIOSH-DART, NOISE, Occupational health, SAFETY, Sampling, System, VPXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, WMXXXX, XDXXXX, XIXXXX, XJXXXX, YEXXXX

Category(s): Collaboration Sought > Licensing, Application > Occupational Safety and Health, ResearchProducts > Computational models/software, Application > Research Materials, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Dental, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Application > Software / Apps, Application > Non-Medical Devices, Application > Medical Devices

MDCK-based Reporter System for Detection of Influenza Viruses, Antiviral Drug Screening, and Analysis of Neutralizing Antibodies

CDC researchers have developed a Madin-Darby Canine Kidney (MDCK) reporter cell line that is exceptionally permissive for influenza virus replication and provides a highly specific, sensitive approach for the simultaneous detection and isolation of influenza viruses. Simplified antibody neutralization assays and high-throughput antiviral drug screening...

Published: 7/25/2024 | Inventor(s): Zhu Guo, Sandra Perez DeBretschneider, Ruben Donis

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, CELL-BASED, Detection, INFLUENZA, MDCK, REPORTER, System, VBXXXX, Viruses, VLXXXX, VOXXXX, WAXXXX, WBXXXX, WFXXXX, WHXXXX, WIXXXX, WJXXXX, WKXXXX, WMXXXX, XAXXXX, XCXXXX, XEXXXX, XHXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, ResearchProducts > Research Equipment, TherapeuticArea > Immunology, ResearchProducts > Antibodies, Application > Research Materials, Application > Occupational Safety and Health, Application > Vaccines, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Consumer Products

Local Positioning System for Position-Time-Condition Correlation, Data-logging and Analysis

This CDC-developed technology describes an automated system for monitoring worker hazard exposures by recording data about where and when hazards occur in a workplace or other environment. This allows the hazards to be avoided and harmful exposures and risks reduced. This field-tested technology consists of an integrated, hand-held electronics instrument...

Published: 7/25/2024 | Inventor(s): Sidney Soderholm, Michael Flemmer, Jennifer Hornsby-Myers, Ramesh Gali, Larry Lee

Keywords(s): apparatus, ASSESSING, CDC Docket Import, CDC Docket Import CDC Prosecuting, Conditions, Method, System, VBXXXX, WAXXXX, WCXXXX, WEXXXX, WFXXXX, WGXXXX, WIXXXX, WMXXXX, XDXXXX, XHXXXX, XIXXXX, XJXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Medical Devices, Application > Software / Apps, ResearchProducts > Research Equipment, Application > Research Materials, Application > Occupational Safety and Health, Application > Non-Medical Devices, Application > Therapeutics, Application > Vaccines, Application > Diagnostics, ResearchProducts > Computational models/software, Application > Consumer Products

Cable-line Safety System: Electro/hydraulic Emergency Stop Device for a Winch, Drum or Capstan

This CDC-developed invention entails a system of electrical and hydraulic circuits used to stop a rotating winch in an emergency. Amongst other locations, one stop switch can be positioned on a capstan winch horn. This location makes it available to a victim entangled in rope being retrieved on a gypsy drum. As designed, the stop circuit could be...

Published: 7/25/2024 | Inventor(s): John Bevan, Gregory Miller, Todd Ruff, Wayne Howie, Jennifer Lincoln, Lewis Martin, Robert Mckibbin, Curtis Clark, Chelsea Woodward

Keywords(s): AE1CXX, AE1XXX, AE2BXX, AE2XXX, AE4XXX, AEXXXX, AFXXXX, AG3XXX, AGXXXX, AXXXXX, CABLE, CABLES, capstan, CDC Docket Import, CDC Docket Import CDC Prosecuting, CDCRM, DEVICE, ELECTRO/HYDRAULIC, EMERGENCY, FISH, Maritime, NIOSH, Occupational health, RXXXXX, SAFETY, Stop, SWITCH, Switches, SWITCHING, System, WEXXXX, WFXXXX, WGXXXX, WINCH, WMXXXX, XDXXXX, XIXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Consumer Products, Application > Non-Medical Devices, Application > Medical Devices, Application > Research Materials, Application > Occupational Safety and Health

Auscultatory Training System and Telemedicine Tool with Accurate Reproduction of Physiological Sounds

This CDC developed auscultatory training apparatus includes a database of prerecorded physiological sounds (e.g., lung, bowel, or heart sounds) stored on a computer for playback. Current teaching tools, which utilize previously recorded sounds, suffer from the disadvantage that playback environments cause considerable distortion and errors in sound...

Published: 7/25/2024 | Inventor(s): Jeffrey Reynolds, Kimberly Friend, William Goldsmith, David Frazer, Walter McKinney

Keywords(s): AA3B6X, AA3BXX, AA3XXX, AAXXXX, AB4XXX, ACXXXX, ADXXXX, AFXXXX, Auscultatory, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, IA1XXX, IA5XXX, IAXXXX, IB1FXX, IB4XXX, ICXXXX, IDXXXX, IXXXXX, NIOSH-HELD, System, TRAINING, VDXXXX, VOXXXX, VPXXXX, WBXXXX, WFXXXX, WHXXXX, WIXXXX, WMXXXX, XDXXXX, XFXXXX, XIXXXX, XJXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, ResearchProducts > Computational models/software, Application > Non-Medical Devices, Application > Consumer Products, TherapeuticArea > Dental, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, Application > Software / Apps, Application > Occupational Safety and Health, Application > Medical Devices, TherapeuticArea > Pulmonology, Application > Research Materials, Application > Diagnostics

Intranasal Nebulizer with Disposable Drug Cartridge for Improved Delivery of Vaccines and Therapeutics

Intranasal delivery is a simple, inexpensive and needle-free route for administration of vaccines and therapeutics. This intranasal delivery technology, developed with Creare LLC., includes low-cost, disposable drug cartridges (DDCs) that mate with a durable hand-held device. The rechargeable-battery-powered device transmits ultrasonic energy to the...

Published: 7/25/2024 | Inventor(s): James Barry, Nabil Elkouh, Mark Bagley, Darin Knaus, Robert Trabka, Eric Friets, James Norris, Mark Papania

Keywords(s): AB1XXX, AB3FXX, AB3GXX, AB3XXX, AB4XXX, Able, ABXXXX, AC1XXX, ACXXXX, AEROSOL, AEROSOL-GENERATING, AEROSOLIZATION, Aerosolized, AEROSOLS, AXXXXX, BACTERIA, Bacterial, BACTERIAL VACCINES, CARTRIDGE, CDC, CDC Docket Import, CDC Docket Import CDC Prosecuting, Chamber, COOLING, DB1XXX, DB2XXX, DB3XXX, DB4XXX, DB5XXX, DBXXXX, DC1XXX, DC2XXX, DC3XXX, DC4XXX, DC5BXX, DC5XXX, DC6XXX, DCXXXX, Delivery, DEVICE, Devices, Disposable, DRUG, Drug Delivery, DXXXXX, FUNGAL, HAND, Having, INSERT, Intranasal, Methods, NASAL, NEBULIZER, NIOSH-PRL, OID-NCIRD-DVD, PLATFORM, Platforms, Pulmonary, respiratory, Respiratory Diseases, respiratory INFECTION, System, SYSTEMS, therapeutic, therapeutic delivery, Vaccine, VACCINE DELIVERY, Vaccine Design, VACCINE DEVELOPMENT, VBXXXX, viral, viral vaccine, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WFXXXX, WJXXXX, WKXXXX, WMXXXX, XDXXXX, YBXXXX, YCXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Occupational Safety and Health, Application > Medical Devices, Application > Diagnostics, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Ophthalmology, Application > Consumer Products, TherapeuticArea > Oncology

Intranasal Dry Powder Inhaler for Improved Delivery of Vaccines and Therapeutics

This Intranasal Dry Powder Inhaler (DPI), developed with Creare, Inc., allows low-cost delivery of powder vaccines. Nasal delivery has numerous advantages compared to traditional injected vaccines, including: 1) safe, needle-less administration by minimally-trained staff or patient; 2) better protection due to mucosal and cross-protection; and 3) decreased...

Published: 7/25/2024 | Inventor(s): James Barry, Darin Knaus, Edward Moynihan, Eric Friets, Mark Bagley, Mark Papania

Keywords(s): AB1XXX, AB3FXX, AB3GXX, ABXXXX, Agents, AXXXXX, BACTERIA, Bacterial, BACTERIAL VACCINES, Biodefense, biosecurity, bioterrorism, Bioterrorist, CDC Docket Import, CDC Docket Import CDC Prosecuting, Child safety device, CHILDHOOD, Children, DB1XXX, DB2XXX, DB3XXX, DB4AXX, DB4BXX, DB4XXX, DB5XXX, DBXXXX, DC1XXX, DC2XXX, DC3XXX, DC4XXX, DC5XXX, DC6XXX, DCXXXX, Delivery, delivery system, DEVELOPED, DEVELOPING, DEVICE, Devices, Disposable, DISPOSAL, Dry, DXXXXX, Field, Field-usable, FUNGAL, Intranasal, MEASLES, NASAL, Needle, OID-NCIRD-DVD, Portable, POWDER, Prevention, respiratory, SAFETY, SELF-ADMINISTRATION, Single-use, System, therapeutic delivery, treatment, VACCINATION, Vaccinations, VACCINE DELIVERY, vaccines, VBXXXX, viral vaccine, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WKXXXX, WMXXXX, XDXXXX, YBXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Medical Devices, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Non-Medical Devices, Application > Consumer Products, Application > Therapeutics

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