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A Genetic System in Yeast for Functional Identification of Human p53 Mutations

Mutations in the p53 gene are associated with 50% of all cancers and nearly 80% of the p53 mutations are missense changes. We have developed genetic assays based in yeast that can functionally categorize expressed p53 mutant proteins. The combined assays are referred to as the FIP53 system. Because human p53 cDNA can be conveniently cloned in yeast,...

Published: 7/25/2024 | Inventor(s): Alberto Inga, Michael Resnick

Keywords(s): CA1XXX, CAXXXX, FUNCTIONAL, GAXXXX, Genetic, Human, Identification, Listed LPM Wong as of 4/15/2015, Mutations, p53, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SACGHS DNA Patent Initial Set, System, X, Yeast

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics, Application > Therapeutics

Ultra-sensitive Diagnostic Detects fg/mL-pg/mL Pathogen/Disease Protein by Visual Color Change

This technology is an ultra-sensitive colorimetric assay, based on an enzyme-catalyzed gold nanoparticle growth process, for detection of disease-associated proteins (biomarkers) and disease diagnosis. Current detection methods, such as ELISA immunoassays, measure concentrations above 0.1 ng/mL in a sample. PCR, although more sensitive than ELISA, requires...

Published: 7/25/2024 | Inventor(s): Dingbin Liu, Xiaoyuan (Shawn) Chen

Keywords(s): assay, AuNPbased, AuNP-based, Biomarkers, CA1XXX, COLORIMETRIC, DAXXXX, Detection, GOLD, Nanoparticle, Ultrasensitive, VCXXXX, VJXXXX, VLXXXX, WBXXXX, XCXXXX, XDXXXX, XHXXXX, YAXXXX, YBXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Application > Medical Devices, ResearchProducts > Research Equipment, Application > Diagnostics, Application > Non-Medical Devices, Application > Research Materials, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology

Generation of Artificial Mutation Controls for Diagnostic Testing

This technology relates to a method of generating artificial compositions that can be used as positive controls in a genetic testing assay, such as a diagnostic assay for a particular genetic disease. Such controls can be used to confirm the presence or absence of a particular genetic mutation. The lack of easily accessible, validated mutant controls...

Published: 7/25/2024 | Inventor(s): Laurina Williams

Keywords(s): AA1XXX, AA5XXX, AA6XXX, AAXXXX, ARTIFICIAL, AXXXXX, CA1AXX, CA1CXX, CA1XXX, CAXXXX, controls, CXXXXX, diagnostic, GAXXXX, GCXXXX, GXXXXX, IA1BXX, IA2XXX, IA3XXX, IA5XXX, IAXXXX, IXXXXX, MUTATION, NA2XXX, OA2XXX, TESTING, VPXXXX, WBXXXX, WHXXXX, WIXXXX, WMXXXX, XBXXXX, XCXXXX, XEXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Software / Apps, Application > Diagnostics, TherapeuticArea > Dermatology, TherapeuticArea > Immunology, TherapeuticArea > Pulmonology, Application > Research Materials, TherapeuticArea > Ophthalmology, TherapeuticArea > Dental, Application > Therapeutics, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Oncology, TherapeuticArea > Neurology, ResearchProducts > Computational models/software, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease

Antagonist of A3 Adenosine Receptor Fluorescent Probes for the Study of Diseases that Involve A3 Signaling

This molecular probe may serve as a companion tool to identify and stratify patient populations based on the prevalence of the target A3 adenosine receptors. Small molecule drugs, A3AR-selective agonists, are currently in advanced clinical trials for the treatment of hepatocellular carcinoma, autoimmune inflammatory diseases, such as rheumatoid arthritis,...

Published: 7/25/2024 | Inventor(s): Kenneth Jacobson

Keywords(s): A3, ADENOSINE, ANTAGONISTS, BINDING, CA1CXX, CA1XXX, CAXXXX, CXXXXX, fluorescent, IA2XXX, IA3XXX, IAXXXX, IXXXXX, Molecular, Novel, Probes, RECEPTOR

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Dermatology, Application > Therapeutics, TherapeuticArea > Immunology, TherapeuticArea > Oncology

Biomarkers for Cancer-Related Fatigue and Their Use in the Management of Such Fatigue (CRF)

The invention relates to the diagnosis and management of cancer-related fatigue (CRF). More specifically the invention relates to identification and measurement of a single Biomarker or a group of biomarkers (e.g. genes) that are associated with cancer related fatigue. The identification and measurement of such biomarkers can be utilized in the diagnosis...

Published: 7/25/2024 | Inventor(s): Leorey Saligan

Keywords(s): CA1AXX, CA1XXX, CAXXXX, Chain, CHIP, CXXXXX, Fatigue, polymerase, REACTION

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Oncology

Diagnostic Biomarker of Metastasis for Improved Clinical Management of Head and Neck Cancer

Squamous Cell Carcinoma of the Head and Neck (HNSCC) is associated with poor prognosis due to the advanced stage of disease (metastasis) typically found at the time of diagnosis. Investigators at the NIH have developed a sensitive method using a protein biomarker for detecting even just a few HNSCC tumor cells in lymph nodes with occult disease. Combination...

Published: 7/25/2024 | Inventor(s): J Silvio Gutkind

Keywords(s): Biomarker, CA1XXX, Carcinoma, squamous cell of head and neck, CAXXXX, CXXXXX, Detection, DSG3, Identification, lymph, MEN 1, Metastasis, nodes, OCCULT, Patent Category - Biotechnology, Sentinel, Squamous cell carcinoma, Squamous cell carcinoma of the head and neck, Zollinger-Ellison syndrome

Category(s): Application > Diagnostics, TherapeuticArea > Oncology

Prostatic Adenocarcinoma Cells Expressing or Lacking the Tumor Suppressor Gene PTEN

PTEN is a tumor suppressor gene that is frequently deleted or mutated in a variety of human cancers, including prostate, breast, endometrial, lung, and ovarian cancers. In prostate cancer cells, PTEN deletion is the most common event observed. The loss of PTEN is thought to play and important role in tumor cell proliferation and metastasis due to...

Published: 4/8/2024 | Inventor(s): Michael Quon, Derek Leroith

Keywords(s): ADENOCARCINOMA, BREAST CANCER, CA1XXX, CANCER, CAXXXX, CCXXXX, Cells, CHARACTERIZATION, Chromosome 7, monosomy, CXXXXX, Deletion 7, endometrial, Expressing, Gene, IGF1R, lung cancer, MEN 1, OVARIAN CANCER, PROSTATE CANCER, PTEN, tumor suppressor, Zollinger-Ellison syndrome

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics, Application > Research Materials

Rapid and Sensitive Detection of Nucleic Acid Sequence Variations

The ability to easily detect small mutations in nucleic acids, such as single base substitutions, can provide a powerful tool for use in cancer detection, perinatal screens for inherited diseases, and analysis of genetic polymorphisms such as genetic mapping or for identification purposes. Current approaches make use of the mismatch that occurs between...

Published: 4/8/2024 | Inventor(s): Kenji Adzuma, Kiyoshi Mizuuchi, Katsuhiko Yanagihara

Keywords(s): (4)r syndrome, AC6XXX, ACXXXX, AXXXXX, C syndrome, CA1AXX, CA1XXX, CAXXXX, Chromosome 4 ring syndrome, Chromosome 6 ring syndrome, Chromosome 7 ring syndrome, CXXXXX, Cystic fibrosis, Detection, DNA, Fragile X syndrome, G syndrome, Genetic, Huntington disease, Huntington disease; Huntington's disease, Hypertelorism with esophageal abnormality and hypospadias, IA6XXX, IAXXXX, Insertion, IXXXXX, Method, Mismatch-Targeted, Muscular dystrophy, Mutations, N syndrome, R(6) syndrome, R(7) syndrome, Syndrome X, Transposon, W syndrome, W syndrome; Syndrome W

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Oncology

Hybridoma C4H3, Monoclonal Antibody to a Specific Peptide-MHC Class II Complex

T lymphocytes play an important role in the immune system by recognizing foreign protein motifs on cells. T lymphocytes are stimulated to recognize these motifs through their interactions with peptide-MHC complexes (pMHC). Thus, studying pMHC is an important aspect of understanding how the immune system works, particularly with regard to the development...

Published: 7/25/2024 | Inventor(s): Ronald Germain

Keywords(s): ANTIBODY, CA1BXX, CA1XXX, CA2AXX, CA2XXX, CAXXXX, Class, COMPLEX, CXXXXX, Hybridoma, Mab, monoclonal, Peptide-MHC, RM, Specific, WIXXXX, XAXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Immunology, TherapeuticArea > Oncology, Application > Research Materials, Application > Diagnostics, ResearchProducts > Antibodies

Probe Set Global Optimization

Available for licensing and commercial development are methods to optimize sequence-based assays such as microarrays, multiplexed PCR or multiplexed antibody methods. This computational method uses numerical optimization to identify an optimal probe set to be used in an assay for the measurement of a specified set of targets. The method incorporates...

Published: 4/8/2024 | Inventor(s): Kevin Brown, Eric Billings

Keywords(s): AA5XXX, AAXXXX, AC4XXX, ACXXXX, assay, AXXXXX, Bacterial, CA1AXX, CA1XXX, CAXXXX, computer methods, CXXXXX, DAXXXX, DXXXXX, Global, IAXXXX, IXXXXX, Nucleotide, OPTIMIZATION, PATHOGEN, Probe, probe set, Protein, SELECTION, Sequences, splice variants, VIRAL DIAGNOSTIC

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology

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