Search Results - breast+cancer

7 Results

Sort By:

Abstract: Tumor cell lines are important tools for the study of cancer. However, most tumor cell lines available today do not mimic physiological tumor development, progression, and host immune responses. Autochthonous tumors include spontaneously occurring tumors and chemical, viral, or physical carcinogen-induced tumors. They are considered to model...

Published: 4/8/2024 | Inventor(s): Jeffrey Schlom, Scott Abrams

Keywords(s): AT-3, Autochthonous Tumor, Autologous Tumor Cell Line, BREAST CANCER, In Vitro Animal Model, Mouse, Murine, Schlom

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials

High Affinity Nanobodies Targeting B7-H3 (CD276) for Treating Solid Tumors

Abstract: CD276 (also called B7-H3) is a pan-cancer antigen expressed in multiple solid tumors and an emerging cancer target. CD276 protein is overexpressed in pancreatic cancer, prostate cancer, breast cancer, colon cancer, lung cancer, and brain tumors (such as neuroblastoma) – making it an ideal target for cancer therapy. Investigators at the National...

Published: 5/21/2024 | Inventor(s): Mitchell Ho, Brad St. Croix, Ruixue Wang, Dan Li

Keywords(s): ADC, Antibody-drug Conjugate, B7-H3, BREAST CANCER, CAR, CD276, chimeric antigen receptor, COLON CANCER, Glioma, HO, lung cancer, Nanobodies, Neuroblastoma, OVARIAN CANCER, Pancreatic Cancer, solid tumors

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Multi-epitope Vaccines against TARP (ME-TARP) for Treating Prostate and Breast Cancer

Abstract: The development of more targeted means of treating cancer is vital. One option for a targeted treatment is the creation of a vaccine that induces an immune response only against cancer cells. In this sense, vaccination involves the introduction of a peptide into a patient that causes the formation of antibodies or T cells that recognize the...

Published: 4/8/2024 | Inventor(s): Lauren Wood, Jay Berzofsky, Brenda Roberson, Masaki Terabe

Keywords(s): BREAST CANCER, CANCER VACCINE, Immunotherapy, PROSTATE CANCER

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines

Aryl Hydantoin Heterocycle Compounds that Target the Androgen Receptor for Prostate Cancer Treatment

Abstract: Prostate cancer is the most prevalent form of cancer among all men in the United States (US). It is also the second leading cause of cancer-related deaths in the US among men, largely due to the progressively treatment resistant nature of the disease. Treatment options for early stage prostate cancer include watchful waiting, radical prostatectomy,...

Published: 4/8/2024 | Inventor(s): Berkley Gryder, Adegboyega Oyelere, Eric Raftery, Subhasish Tapadar, Nicholas Aboreden, William Figg

Keywords(s): Androgen Deficiency Disorders, Androgen dysfunctional Disorders, Androgen Receptor, Androgen Receptor Inverse Agonists, Anti-androgens, AR, ARIA, BREAST CANCER, Georgia Institute of Technology, GIT, Gryder, Hyperandrogenism, PROSTATE CANCER

Category(s): Application > Therapeutics, TherapeuticArea > Endocrinology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Multifunctional RNA Nanoparticles as Cancer and HIV Therapeutics

Abstract: The promise of RNA interference based therapeutics is made evident by the recent surge of biotechnological drug companies that pursue such therapies and their progression into human clinical trials. The present invention discloses novel RNA and RNA/DNA nanoparticles including multiple siRNAs, RNA aptamers, fluorescent dyes, and proteins....

Published: 8/14/2024 | Inventor(s): Bruce Shapiro, Kirill Afonin, Angelica Martins, Mathias Viard

Keywords(s): BREAST CANCER, Nanoparticle, nanotechnology, RNAi, SiRNA

Category(s): TherapeuticArea > Infectious Disease, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing

GATA-3 Reporter Plasmids for Revealing Underlying Mechanisms in Breast Cancer

Abstract: GATA-3 is a transcription factor that is highly expressed in normal cells of the mammary luminal epithelium. GATA-3 plays a regulatory role in determining the fate of cells in the mammary gland. Disruption of GATA-3 expression leads to defects in the development of mammary cells, including an inability to differentiate properly into the correct...

Published: 7/25/2024 | Inventor(s): Hosein Kouros-Mehr, Jeffrey Green

Keywords(s): BREAST CANCER, diagnostic, GATA-3 expression, prognostic

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology

Prostatic Adenocarcinoma Cells Expressing or Lacking the Tumor Suppressor Gene PTEN

PTEN is a tumor suppressor gene that is frequently deleted or mutated in a variety of human cancers, including prostate, breast, endometrial, lung, and ovarian cancers. In prostate cancer cells, PTEN deletion is the most common event observed. The loss of PTEN is thought to play and important role in tumor cell proliferation and metastasis due to...

Published: 4/8/2024 | Inventor(s): Michael Quon, Derek Leroith

Keywords(s): ADENOCARCINOMA, BREAST CANCER, CA1XXX, CANCER, CAXXXX, CCXXXX, Cells, CHARACTERIZATION, Chromosome 7, monosomy, CXXXXX, Deletion 7, endometrial, Expressing, Gene, IGF1R, lung cancer, MEN 1, OVARIAN CANCER, PROSTATE CANCER, PTEN, tumor suppressor, Zollinger-Ellison syndrome

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics, Application > Research Materials