Search Results - jay+berzofsky

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Adjuvanted Mucosal Subunit Vaccines for Preventing SARS-CoV-2 Transmission and Infection

Abstract: The Corona virus disease, 2019 (COVID-19) pandemic is a worldwide public health crisis with over 153 million confirmed cases and 3.2 million deaths as of April 2021. COVID-19 is caused by a novel coronavirus called SARS-CoV-2. SARS-COV-2 infects hosts via its spike (S) protein, which has two portions, S1 that binds the cell and S2 that is...

Published: 8/14/2024 | Inventor(s): Jay Berzofsky, Yongjun Sui

Keywords(s):

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease

Exo-Clean Technology for Purifying Extracellular Vesicle Preparations from Contaminants

Abstract: Extracellular Vesicles (EVs), including exosomes and microvesicles, are nanometer-sized membranous vesicles that can carry different types of cargos, such as proteins, nucleic acids and metabolites. EVs are produced and released by most cell types. They act as biological mediators for intercellular communication via delivery of their cargos....

Published: 8/14/2024 | Inventor(s): Jennifer Jones, Jay Berzofsky, Joshua Welsh, Katherine McKinnon

Keywords(s): Affinity, Biomarkers, CHROMATOGRAPHIC, EVs, Exo-Clean, Exosomes, Extracellular Vesicles, High-throughput, Jones, Microvesicles, purification, Resin

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Endocrinology, TherapeuticArea > Immunology

Multi-epitope Vaccines against TARP (ME-TARP) for Treating Prostate and Breast Cancer

Abstract: The development of more targeted means of treating cancer is vital. One option for a targeted treatment is the creation of a vaccine that induces an immune response only against cancer cells. In this sense, vaccination involves the introduction of a peptide into a patient that causes the formation of antibodies or T cells that recognize the...

Published: 4/8/2024 | Inventor(s): Lauren Wood, Jay Berzofsky, Brenda Roberson, Masaki Terabe

Keywords(s): BREAST CANCER, CANCER VACCINE, Immunotherapy, PROSTATE CANCER

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines

3-o-sulfo-galactosylceramide Analogs as Activators of Type II Natural Killer T (NKT) Cells to Reduce Cancer Metastasis to the Lung

Abstract: Lung metastases are a sign of widespread cancer with poor survival rate. Lung malignancies can originate from almost any cancer type spread via the blood stream. Most common lung metastases are from melanoma, breast cancer, bladder cancer, colon cancer, prostate cancer, neuroblastoma, and sarcoma. Living more than 5 years with lung metastases...

Published: 8/5/2024 | Inventor(s): Lise Pasquet, Jay Berzofsky, Amy Howell, Masaki Terabe, Kaddy Camara

Keywords(s): 3-o-sulfo-galactosylceramide Analogs, Berzofsky, C24:2, Immunotherapy, lung cancer, Metastasis, Natural Killer cells, NKT cells, Sulfatide Analogs, T Cells

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Immunology

Cancer Vaccines against POTE for Treating Solid Tumors

Abstract: POTE is a novel tumor antigen expressed in a variety of cancers including breast, prostate, colon, lung, ovary, and pancreas cancers. POTE has limited expression in normal tissues and therefore a specific target for cancer treatments, including immunotherapy. The researchers seek statements of capability or interest from parties interested...

Published: 8/5/2024 | Inventor(s): Jay Berzofsky, Yi-Hisang Huang, Masaki Terabe, Ira Pastan

Keywords(s): CANCER, immunogenic peptides, Immunotherapy, POTE, Vaccine

Category(s): Application > Vaccines, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Cancer Therapeutic based on Stimulation of Natural Killer T-cell Anti-tumor Activity

Abstract: Natural killer T cells (NKT) are a unique lymphocyte population that has T-cell and NK cell functional properties in order to rapidly elicit an immune response. alpha-galactosylceramide (alpha-GalCer) is a potent NKT stimulator and induces of IFN-gamma release to promote immunity against tumors and infectious agents. Humans have natural...

Published: 4/8/2024 | Inventor(s): Masaki Terabe, Jessica O'Konek, Petr Illarionov, Jay Berzofsky, Gurdyal Besra

Keywords(s): ANTIBODY, Immunity, NKT activity

Category(s): Application > Therapeutics, TherapeuticArea > Immunology, TherapeuticArea > Oncology, Collaboration Sought > Licensing

Biomarker Analysis Software for High-Throughput Diagnostic Multiplex Data

Abstract: Extracellular vesicles (EVs) are lipid bilayer-enclosed particles that are released from cells. EVs may contain proteins derived from their cells of origin with the potential as diagnostic biomarkers indicating the state of the cells when released. However, due to their small size (50-1000nm), the methods currently used to phenotype EVs have...

Published: 8/14/2024 | Inventor(s): Joshua Welsh, Jennifer Jones, Jay Berzofsky

Keywords(s): Berzofsky, Biomarker, EV, Extracellular Vesicles, High-throughput, Jones, Lipid Bilayer-Enclosed Particles, software

Category(s): Application > Software / Apps, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Optical Configuration Methods for Spectral Scatter Flow Cytometry

Abstract: Multi-parameter flow cytometry has been extensively used in multiple disciplines of biological discoveries, including immunology and cancer research. However, the disadvantage of traditional flow cytometry platforms using excitation lasers and fluorescence detectors is spectral overlap when using multiple dyes on the same biological sample....

Published: 8/14/2024 | Inventor(s): Jennifer Jones, Joshua Welsh, William Telford, Jay Berzofsky, Ariel Rosner

Keywords(s): flow cytometry, High-throughput Characterization, Jones, Molecular NanoTag, Multispectral Detection, Optical Configuration

Category(s): TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Immunology, Application > Research Materials