Search Results - jay+berzofsky

9 Results

Sort By:

Compositions and Methods for Producing Dendritic Cell-based Vaccines with Enhanced Efficacy

Summary: The National Cancer Institute (NCI) is seeking research co-development partners and/or licensees for NCI’s compositions and methods to enhance the efficacy of dendritic cell (DC)-based cancer vaccines. Description of Technology: Current dendritic cell (DC)-based cancer vaccines are limited by impaired DC function due to cancer-driven...

Published: 8/21/2025 | Updated: 7/15/2025 | Inventor(s): Jay Berzofsky, Shweta Tiwary

Keywords(s):

Category(s): TherapeuticArea > Oncology, TherapeuticArea > Immunology, Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Adjuvanted Mucosal Subunit Vaccines for Preventing SARS-CoV-2 Transmission and Infection

Summary: Inventors are seeking licensing and/or co-development research collaborations for a unique novel molecular Adjuvanted Mucosal Subunit Vaccine to prevent SARS-CoV-2 transmission and infection. Description of Technology: The Corona virus disease, 2019 (COVID-19) pandemic is a worldwide public health crisis with over 153 million confirmed...

Published: 4/24/2026 | Updated: 8/2/2023 | Inventor(s): Jay Berzofsky, Yongjun Sui

Keywords(s):

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease

Exo-Clean Technology for Purifying Extracellular Vesicle Preparations from Contaminants

Description of Technology: Extracellular Vesicles (EVs), including exosomes and microvesicles, are nanometer-sized membranous vesicles that can carry different types of cargos, such as proteins, nucleic acids and metabolites. EVs are produced and released by most cell types. They act as biological mediators for intercellular communication via delivery...

Published: 4/23/2026 | Updated: 8/2/2023 | Inventor(s): Jennifer Jones, Jay Berzofsky, Joshua Welsh, Katherine McKinnon

Keywords(s): Affinity, Biomarkers, CHROMATOGRAPHIC, EVs, Exo-Clean, Exosomes, Extracellular Vesicles, High-throughput, Jones, Microvesicles, purification, Resin

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Endocrinology, TherapeuticArea > Immunology

Multi-epitope Vaccines against TARP (ME-TARP) for Treating Prostate and Breast Cancer

Abstract: The development of more targeted means of treating cancer is vital. One option for a targeted treatment is the creation of a vaccine that induces an immune response only against cancer cells. In this sense, vaccination involves the introduction of a peptide into a patient that causes the formation of antibodies or T cells that recognize the...

Published: 4/22/2025 | Updated: 8/2/2023 | Inventor(s): Lauren Wood, Jay Berzofsky, Brenda Roberson, Masaki Terabe

Keywords(s): BREAST CANCER, CANCER VACCINE, Immunotherapy, PROSTATE CANCER

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines

3-o-sulfo-galactosylceramide Analogs for Targeting Lung Metastases

Summary: The NCI seeks research co-development partners and/or licensees for the sulfatide analog, C24:2 Description of Technology: Lung metastases represent a major clinical challenge in advanced cancer, with poor survival rates and no effective therapies to prevent their development. Researchers at the National Cancer Institute (NCI) have developed...

Published: 4/24/2026 | Updated: 8/2/2023 | Inventor(s): Lise Pasquet, Jay Berzofsky, Amy Howell, Masaki Terabe, Kaddy Camara

Keywords(s): 3-o-sulfo-galactosylceramide Analogs, Berzofsky, C24:2, Immunotherapy, lung cancer, Metastasis, Natural Killer cells, NKT cells, Sulfatide Analogs, T Cells

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Immunology

Cancer Vaccines against POTE for Treating Solid Tumors

Abstract: POTE is a novel tumor antigen expressed in a variety of cancers including breast, prostate, colon, lung, ovary, and pancreas cancers. POTE has limited expression in normal tissues and therefore a specific target for cancer treatments, including immunotherapy. The researchers seek statements of capability or interest from parties interested...

Published: 4/22/2025 | Updated: 8/2/2023 | Inventor(s): Jay Berzofsky, Yi-Hisang Huang, Masaki Terabe, Ira Pastan

Keywords(s): CANCER, immunogenic peptides, Immunotherapy, POTE, Vaccine

Category(s): Application > Vaccines, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Cancer Therapeutic based on Stimulation of Natural Killer T-cell Anti-tumor Activity

Abstract: Natural killer T cells (NKT) are a unique lymphocyte population that has T-cell and NK cell functional properties in order to rapidly elicit an immune response. alpha-galactosylceramide (alpha-GalCer) is a potent NKT stimulator and induces of IFN-gamma release to promote immunity against tumors and infectious agents. Humans have natural...

Published: 4/22/2025 | Updated: 8/2/2023 | Inventor(s): Masaki Terabe, Jessica O'Konek, Petr Illarionov, Jay Berzofsky, Gurdyal Besra

Keywords(s): ANTIBODY, Immunity, NKT activity

Category(s): Application > Therapeutics, TherapeuticArea > Immunology, TherapeuticArea > Oncology, Collaboration Sought > Licensing

Biomarker Analysis Software for High-Throughput Diagnostic Multiplex Data

Summary: The NCI seeks research co-development partners and/or licensees for a biomarker analysis software for high-throughput diagnostic multiplex data. Description of Technology: Extracellular vesicles (EVs) are lipid bilayer-enclosed particles that are released from cells. EVs may contain proteins derived from their cells of origin with the potential...

Published: 4/23/2026 | Updated: 8/2/2023 | Inventor(s): Joshua Welsh, Jennifer Jones, Jay Berzofsky

Keywords(s): Berzofsky, Biomarker, EV, Extracellular Vesicles, High-throughput, Jones, Lipid Bilayer-Enclosed Particles, software

Category(s): Application > Software / Apps, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Optical Configuration Methods for Spectral Scatter Flow Cytometry

Summary: The inventors are constructing a prototype system and seek licensing or co-development opportunities from commercial flow cytometry platforms to optimize the invention for use in combination with their proprietary platforms. Description of Technology: Multi-parameter flow cytometry has been extensively used in multiple disciplines of biological...

Published: 4/23/2026 | Updated: 8/2/2023 | Inventor(s): Jennifer Jones, Joshua Welsh, William Telford, Jay Berzofsky, Ariel ("Ari") Rosner

Keywords(s): flow cytometry, High-throughput Characterization, Jones, Molecular NanoTag, Multispectral Detection, Optical Configuration

Category(s): TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Immunology, Application > Research Materials