Search Results - biomarker

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A Viral Exposure Signature to Define and Detect Early Onset Hepatocellular Carcinoma

Abstract: Early detection of liver cancer, such as hepatocellular carcinoma (HCC), is key to improve cancer-related mortality. More than 800,000 people are diagnosed with this cancer each year throughout the world. Liver cancer is also a leading cause of cancer deaths worldwide, accounting for more than 700,000 deaths each year. Currently, millions...

Published: 4/8/2024 | Inventor(s): Xin Wei Wang, Jinping Liu, Wei Tang

Keywords(s): Biomarker, HCC, hepatocellular carcinoma, Liver cancer, viral infection, Wang

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Diagnostics

Tumor Tissues Harboring Mutations in cAMP-specific Phosphodiesterases

Abstract: The National Institute of Child Health and Human Development (NICHD), Division of Intramural Research, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize clinical samples with genetic mutations associated with endocrine tumors. Researchers at the...

Published: 4/8/2024 | Inventor(s): Constantine Stratakis, Anelia Horvath, Kit Man Tsang

Keywords(s): Biomarker, Clinical Samples, Endocrine Tumors, Phosphodiesterase Inhibitors, Research Tools

Category(s): TherapeuticArea > Oncology, Application > Research Materials, Collaboration Sought > Licensing

Molecular Nanotags for Detection of Single Molecules

Abstract: Biological nanoparticles, like extracellular vesicles (EVs), possess unique biological characteristics making them attractive therapeutic agents, targets, or disease biomarkers. However, their use is hindered by the lack of tools available to accurately detect, sort, and analyze. Flow cytometers are used to sort and study individual cells....

Published: 4/8/2024 | Inventor(s): Jennifer Jones, William Telford

Keywords(s): Biological Nanoparticle, Biomarker, EVs, Extracellular Vesicles, flow cytometer, Jones, Nanoscale Molecular Tags, Nanotags

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Research Materials, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology

Anti-CD133 Monoclonal Antibodies as Cancer Therapeutics

Abstract: Most early work on CD133 was carried out using one of two monoclonal antibodies (mAbs), AC133 and AC141, which recognize an undefined glycosylated epitope of CD 133. Researchers from NCI's Pharmacodynamic Assay Development and Implementation Section generated novel anti-human CD133 monoclonal antibodies from large extracellular domain loops...

Published: 4/8/2024 | Inventor(s): Thomas Pfister, Robert Kinders, Allison Marrero

Keywords(s): Anti-CD133, Biomarker, CANCER, Diagnostic Tool, Immunology, Rabbit Monoclonal Antibodies, screening

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Therapeutics, TherapeuticArea > Oncology

Gene Signature for Predicting Solid Tumors Patient Prognosis

Abstract: HCC is the most frequent malignant tumor in the liver and the third leading cause of cancer death worldwide. A progressive sequence of somatic mutations and epigenetic changes of oncogenes or tumor suppressor genes are believed to cause tumor development. However, high genomic instability in tumors causes the accumulation of genomic aberrations...

Published: 4/8/2024 | Inventor(s): Xin Wei Wang, Stephanie Roessler

Keywords(s): Biomarker, driver gene, gene signature, HCC, hepatocellular carcinoma, prognostic

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Oncology

Sensitive and Economic RNA Virus Detection Using a Novel RNA Preparation Method

Abstract: DNA or RNA-based diagnostic tests for infectious diseases are critical in modern medicine. The current gold standard for COVID-19 detection is testing SARS-CoV-2 viral RNA by quantitative reverse transcription Polymerase Chain Reaction (RT-qPCR). This method involves patient sample collection with a nasopharyngeal swab, storage of the swab...

Published: 4/8/2024 | Inventor(s): Bin Guan, Robert Hufnagel

Keywords(s): Biomarker, Chelating Resin, Chelex Resin, COVID, COVID-19, DNA/RNA diagnostic test, Extraction-free Detection, Infectious Diseases, SARS-CoV-2, virus

Category(s): TherapeuticArea > Oncology, Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing

Biomarker Analysis Software for High-Throughput Diagnostic Multiplex Data

Abstract: Extracellular vesicles (EVs) are lipid bilayer-enclosed particles that are released from cells. EVs may contain proteins derived from their cells of origin with the potential as diagnostic biomarkers indicating the state of the cells when released. However, due to their small size (50-1000nm), the methods currently used to phenotype EVs have...

Published: 8/14/2024 | Inventor(s): Joshua Welsh, Jennifer Jones, Jay Berzofsky

Keywords(s): Berzofsky, Biomarker, EV, Extracellular Vesicles, High-throughput, Jones, Lipid Bilayer-Enclosed Particles, software

Category(s): Application > Software / Apps, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Use of Vitronectin as a Biomarker for the Detection of Dengue Hemorrhagic Fever

Dengue hemorrhagic fever (DHF) is a severe, potentially deadly infection spread by mosquitos. CDC scientists have identified vitronectin as an important biomarker of DHF. They have shown vitronectin is significantly reduced in DHF and severe dengue infections when compared to dengue non-hemorrhagic fever patients. Presently, DHF is established by assessing...

Published: 7/25/2024 | Inventor(s): Momar Ndao, Kay Tomashek, Betty Poole-Smith, Elizabeth Hunsperger

Keywords(s): assay, Biomarker, DA4BXX, DA4XXX, DAXXXX, DENGUE, Detection, diagnostic, DIFFERENTIATION, DXXXXX, FEVER, HEMORRHAGIC, HOST, UB1XXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics, TherapeuticArea > Infectious Disease

Diagnostic Biomarker of Metastasis for Improved Clinical Management of Head and Neck Cancer

Squamous Cell Carcinoma of the Head and Neck (HNSCC) is associated with poor prognosis due to the advanced stage of disease (metastasis) typically found at the time of diagnosis. Investigators at the NIH have developed a sensitive method using a protein biomarker for detecting even just a few HNSCC tumor cells in lymph nodes with occult disease. Combination...

Published: 7/25/2024 | Inventor(s): J Silvio Gutkind

Keywords(s): Biomarker, CA1XXX, Carcinoma, squamous cell of head and neck, CAXXXX, CXXXXX, Detection, DSG3, Identification, lymph, MEN 1, Metastasis, nodes, OCCULT, Patent Category - Biotechnology, Sentinel, Squamous cell carcinoma, Squamous cell carcinoma of the head and neck, Zollinger-Ellison syndrome

Category(s): Application > Diagnostics, TherapeuticArea > Oncology