Search Results - prognostic

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SLCO1B3 Genotyping to Predict a Survival Prognosis of Prostate Cancer

Abstract: Steroid hormones have been implicated to play a fundamental role in the pathogenesis of prostate cancer. Polymorphisms in the genes that code for enzymes, or hormones involved in androgen regulatory pathway, reportedly influence risk for developing prostate cancer. Since many membrane transporters are modulators of steroid hormones absorption...

Published: 4/8/2024 | Inventor(s): William Figg, Alex Sparreboom, Douglas Price, Akinobu Hamada

Keywords(s): Androgen-directed Therapy, Biomarkers, diagnostic, Figg, genetic markers, Genomics, Hormone-Refractory, personalized medicine, predictive markers, prognostic, PROSTATE, SLCO1B3

Category(s): TherapeuticArea > Endocrinology, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Diagnostics, TherapeuticArea > Oncology

Gene Signature for Predicting Solid Tumors Patient Prognosis

Abstract: HCC is the most frequent malignant tumor in the liver and the third leading cause of cancer death worldwide. A progressive sequence of somatic mutations and epigenetic changes of oncogenes or tumor suppressor genes are believed to cause tumor development. However, high genomic instability in tumors causes the accumulation of genomic aberrations...

Published: 4/8/2024 | Inventor(s): Xin Wei Wang, Stephanie Roessler

Keywords(s): Biomarker, driver gene, gene signature, HCC, hepatocellular carcinoma, prognostic

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Oncology

Ratio Based Biomarkers for the Prediction of Cancer Survival

Abstract: The AKT pathway plays a key role in the regulation of cellular survival, apoptosis, and protein translation and has been shown to have prognostic significance in a number of cancers. Recently, the inventors have identified several functions of the AKT pathway in certain cancers, such as extrahepatic cholangiocarcinoma (EHCC). The NCI seeks...

Published: 4/8/2024 | Inventor(s): Stephen Hewitt, Joon-Yong Chung, Udayan Guha

Keywords(s): AKT pathway, diagnostic, extrahepatic cholangiocarcinoma, prognostic

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Diagnostics, TherapeuticArea > Oncology

Diagnostic Assay for Determining Patient Response to Apoptosis-related Cancer Therapy

Abstract: Many known chemotherapeutic drugs kill abnormal cells through a process called apoptosis. Bcl-2 proteins are negative regulators of apoptosis that control cell survival and death. Increased expression of anti-apoptotic Bcl-2 proteins commonly occurs in up to 30% of all cancers, providing cancer cells a pro-survival advantage to evade cell...

Published: 4/8/2024 | Inventor(s): Apurva Srivastava, Dominic Esposito, Jeevan Govindharajulu, Ralph Parchment, James Doroshow

Keywords(s): APOPTOSIS, BCL-2, IMMUNOASSAY, Pharmacodynamic Biomarkers, Pro-Apoptotic, prognostic, Srivastava

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease

A Gene-Based Prognostic for Hepatocellular Carcinoma Patient Response to Adjuvant Transcatheter Arterial Chemoembolization

Abstract: Hepatocellular Carcinoma (HCC) is one of the most common cancers worldwide with largely unfavorable outcomes due to a lack of effective treatment options for patients in the later state of disease. The gold standard of care for HCC patients with intermediate to locally advanced tumors is transcatheter arterial chemoembolization (TACE), a procedure...

Published: 4/8/2024 | Inventor(s): Xin Wei Wang, Valerie Miller

Keywords(s): Gene-Expression Signature, hepatocellular carcinoma, Patient Stratification, prognostic

Category(s): Application > Diagnostics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

GATA-3 Reporter Plasmids for Revealing Underlying Mechanisms in Breast Cancer

Abstract: GATA-3 is a transcription factor that is highly expressed in normal cells of the mammary luminal epithelium. GATA-3 plays a regulatory role in determining the fate of cells in the mammary gland. Disruption of GATA-3 expression leads to defects in the development of mammary cells, including an inability to differentiate properly into the correct...

Published: 7/25/2024 | Inventor(s): Hosein Kouros-Mehr, Jeffrey Green

Keywords(s): BREAST CANCER, diagnostic, GATA-3 expression, prognostic

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology