Search Results - apurva+srivastava

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Anti-Py1235-Met Immunological Binding Reagent as Cancer Diagnostic

Abstract: This technology consists of highly specific rabbit monoclonal antibodies reactive with phosphorylated tyrosine located at amino acid 1235 in the human MET sequence. Binding to this pYl235 residue is independent of the phosphorylation of other tyrosines in the vicinity (1230 and 1234), does not cross-react with these nearby phosphotyrosine...

Published: 4/8/2024 | Inventor(s): Apurva Srivastava, Thomas Pfister, Mario Navas, James Doroshow, Ralph Parchment

Keywords(s): ANTIBODY, Companion Diagnostic, diagnostic, MET, Rabbit Monoclonal Antibody, tyrosine kinase inhibitor

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology

Diagnostic Assay for Determining Patient Response to Apoptosis-related Cancer Therapy

Abstract: Many known chemotherapeutic drugs kill abnormal cells through a process called apoptosis. Bcl-2 proteins are negative regulators of apoptosis that control cell survival and death. Increased expression of anti-apoptotic Bcl-2 proteins commonly occurs in up to 30% of all cancers, providing cancer cells a pro-survival advantage to evade cell...

Published: 4/8/2024 | Inventor(s): Apurva Srivastava, Dominic Esposito, Jeevan Govindharajulu, Ralph Parchment, James Doroshow

Keywords(s): APOPTOSIS, BCL-2, IMMUNOASSAY, Pharmacodynamic Biomarkers, Pro-Apoptotic, prognostic, Srivastava

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease