Search Results - companion+diagnostic

2 Results

Sort By:

Anti-Py1235-Met Immunological Binding Reagent as Cancer Diagnostic

Abstract: This technology consists of highly specific rabbit monoclonal antibodies reactive with phosphorylated tyrosine located at amino acid 1235 in the human MET sequence. Binding to this pYl235 residue is independent of the phosphorylation of other tyrosines in the vicinity (1230 and 1234), does not cross-react with these nearby phosphotyrosine...

Published: 4/8/2024 | Inventor(s): Apurva Srivastava, Thomas Pfister, Mario Navas, James Doroshow, Ralph Parchment

Keywords(s): ANTIBODY, Companion Diagnostic, diagnostic, MET, Rabbit Monoclonal Antibody, tyrosine kinase inhibitor

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology

Method for HLA LOH Detection in Liquid Biopsies

Abstract: Human leukocyte antigen (HLA) LOH (LOH) is a known resistance mechanism by which cancers evade T cell receptor-(TCR-)based immunotherapies. This class of therapies includes immune checkpoint inhibition (ICI, e.g., Pembrolizumab), engineered TCR (T cell receptor)-T cell adoptive transfer, tumor infiltrating lymphocytes (TIL), T-cell engagers,...

Published: 5/8/2024 | Inventor(s): Andrew Sinkoe, James Gulley, Cem Sievers

Keywords(s): Companion Diagnostic, Gulley, HLA, Human Leukocyte Antigen, ICI, Immune Checkpoint Inhibition, Immunotherapy, LOH, Loss of Heterozygosity, Sinkoe, T cell therapy

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics