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Diagnostic Assay for Determining Patient Response to Apoptosis-related Cancer Therapy

Abstract: Many known chemotherapeutic drugs kill abnormal cells through a process called apoptosis. Bcl-2 proteins are negative regulators of apoptosis that control cell survival and death. Increased expression of anti-apoptotic Bcl-2 proteins commonly occurs in up to 30% of all cancers, providing cancer cells a pro-survival advantage to evade cell...

Published: 4/8/2024 | Inventor(s): Apurva Srivastava, Dominic Esposito, Jeevan Govindharajulu, Ralph Parchment, James Doroshow

Keywords(s): APOPTOSIS, BCL-2, IMMUNOASSAY, Pharmacodynamic Biomarkers, Pro-Apoptotic, prognostic, Srivastava

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease