Search Results - fever

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Murine Models of an Autoinflammatory Disease, Familial Mediterranean Fever (FMF), to Study the Pathophysiology of Inherited Disorders of Inflammation and Evaluate New Therapies

This technology includes mouse models (heterozygous for the knock-in (KI) and homozygous for the knock-out (KO)) to be used as research reagents and to study molecular mechanisms and potential therapies for Familial Mediterranean fever (FMF). FMF is the prototype of a group of inherited disorders characterized by recurring, spontaneous episodes of fever...

Published: 7/25/2024 | Inventor(s): Jae Chae, Daniel ("Dan") Kastner

Keywords(s): Autoinfla~-~atory, Autoinflamatory, Disease, FAMILIAL, FEVER, FMF, MEDITERRANEAN, Models, Murine, VPXXXX, WIXXXX, XEXXXX

Category(s): Application > Therapeutics, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Dental, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease

Virus Replicon Particles as Rift Valley Fever Vaccines

Rift Valley fever (RVF) virus primarily infects animals but also has the capacity to infect humans. The disease causes abortion and death among RVF-infected livestock, resulting in substantial economic loss to people living in many parts of Africa and Arabian Peninsula. Currently, there is no commercial vaccine for RVF. CDC scientists have developed...

Published: 7/25/2024 | Inventor(s): Cesar Albarino, Brian Bird, Stuart Nichol, Kimberly Dodd

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, DC5BXX, DC5XXX, DCXXXX, DXXXXX, FEVER, OID-NCEZID-DHCPP, PARTICLES, Replicon, RIFT, THEREOF, Valley, virus, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WFXXXX, WIXXXX, WJXXXX, WMXXXX, XAXXXX, XCXXXX, XEXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, ResearchProducts > Antibodies, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, Application > Occupational Safety and Health, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, Application > Vaccines, Application > Consumer Products, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Dental

Real-time RT-PCR Assay for the Detection of Rift Valley Fever Virus in Humans and Livestock

A quantitative RT-PCR-based assay has been developed to rapidly detect all known strains of Rift Valley fever virus (RVFV). RVFV infections occur in both humans and livestock animals resulting in significant mortality and economic loss. Upon outbreak, RVFV has been known to cause devastating loss among livestock (primarily sheep and cattle) with outbreaks...

Published: 7/25/2024 | Inventor(s): Stuart Nichol, Brian Bird

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DDXXXX, Diagnosis, DXXXXX, FEVER, Kits, Methods, Pan-Rift, QUANTITATIVE, REAL-TIME, RT-PCR, Valley, VBXXXX, virus, VLXXXX, VOXXXX, WAXXXX, WDXXXX, WFXXXX, WIXXXX, WMXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Consumer Products, TherapeuticArea > Infectious Disease, Application > Occupational Safety and Health, Application > Research Materials, Application > Diagnostics, Application > Vaccines, Application > Therapeutics

Novel Rift Valley Fever Virus Vaccines

This invention relates to recombinant Rift Valley fever (RVF) viruses containing deletions in one or more virulence genes. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent RVF infection in livestock and humans. The recombinant RVF viruses grow to high titers, provide protective...

Published: 7/25/2024 | Inventor(s): Cesar Albarino, Stuart Nichol, Thomas Ksiazek, Brian Bird

Keywords(s): Biodefense, bioterrorism, Bioterrorist, CDC Docket Import, CDC Docket Import CDC Prosecuting, DB4BXX, DB4XXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DEVELOPING, DXXXXX, FEVER, Livestock, Method, methodology, Methods, Mosquito, Mosquitoes, OID-NCEZID-DHCPP, recombinant, Recombinant DNA, RIFT, rift valley, rift valley fever, rift valley fever virus, RVF, travel, traveler, travelers, tropical, Vaccine, Valley, VBXXXX, Vector, Vector-based, Vector-borne, Vector-borne diseases, VETERINARY, VETERINARY vaccine, viral, virus, Viruses, VLXXXX, VOXXXX, WAXXXX, WIXXXX, WMXXXX, XEXXXX, XHXXXX, YBXXXX, YCXXXX, Zoo, Zoonotic

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines, Application > Consumer Products, Application > Diagnostics, ResearchProducts > Research Equipment, Application > Research Materials

Reduced Virulence Crimean-Congo Hemorrhagic Fever Virus for Vaccine Development

This invention relates to a genetically modified hemorrhagic fever virus that can be used as an effective live vaccine agent. Hemorrhagic fever evades the human immune response using the viral ovarian tumor domain (vOTU) protease, which inhibits critical host-immunity functions. The present genetically modified virus has a vOTU protease with decreased...

Published: 7/25/2024 | Inventor(s): Scott Pegan, MIchelle Deaton, Stuart Nichol, Eric Bergeron

Keywords(s): ABLATION, Activities, Crimean-Congo, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DeiSGylating, Deubiqutinating, Domain, DXXXXX, FEVER, HEMORRHAGIC, OVARIAN, Protease's, SIMULTANEOUS, tumor, Vaccine, virus

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Research Materials

Use of Vitronectin as a Biomarker for the Detection of Dengue Hemorrhagic Fever

Dengue hemorrhagic fever (DHF) is a severe, potentially deadly infection spread by mosquitos. CDC scientists have identified vitronectin as an important biomarker of DHF. They have shown vitronectin is significantly reduced in DHF and severe dengue infections when compared to dengue non-hemorrhagic fever patients. Presently, DHF is established by assessing...

Published: 7/25/2024 | Inventor(s): Momar Ndao, Kay Tomashek, Betty Poole-Smith, Elizabeth Hunsperger

Keywords(s): assay, Biomarker, DA4BXX, DA4XXX, DAXXXX, DENGUE, Detection, diagnostic, DIFFERENTIATION, DXXXXX, FEVER, HEMORRHAGIC, HOST, UB1XXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics, TherapeuticArea > Infectious Disease