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This invention relates to recombinant Rift Valley fever (RVF) viruses containing deletions in one or more virulence genes. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent RVF infection in livestock and humans. The recombinant RVF viruses grow to high titers, provide protective...

Published: 7/25/2024 | Inventor(s): Cesar Albarino, Stuart Nichol, Thomas Ksiazek, Brian Bird

Keywords(s): Biodefense, bioterrorism, Bioterrorist, CDC Docket Import, CDC Docket Import CDC Prosecuting, DB4BXX, DB4XXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DEVELOPING, DXXXXX, FEVER, Livestock, Method, methodology, Methods, Mosquito, Mosquitoes, OID-NCEZID-DHCPP, recombinant, Recombinant DNA, RIFT, rift valley, rift valley fever, rift valley fever virus, RVF, travel, traveler, travelers, tropical, Vaccine, Valley, VBXXXX, Vector, Vector-based, Vector-borne, Vector-borne diseases, VETERINARY, VETERINARY vaccine, viral, virus, Viruses, VLXXXX, VOXXXX, WAXXXX, WIXXXX, WMXXXX, XEXXXX, XHXXXX, YBXXXX, YCXXXX, Zoo, Zoonotic

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines, Application > Consumer Products, Application > Diagnostics, ResearchProducts > Research Equipment, Application > Research Materials