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Real-Time PCR Assay for HIV-1 Subtype Diagnosis and Global Surveillance of Drug Resistance

CDC researchers have developed a patented set of RT-PCR and sequencing primers based on HIV-1 group M sequences. Evaluation of the primers using samples collected around the world demonstrated broad detection capacity for multiple HIV-1 group subtypes and predominant circulating recombinant forms. Commercially available HIV-1 drug resistance (HIVDR)...

Published: 7/25/2024 | Inventor(s): Joshua Devos, Nicholas Wagar, Zhiyong Zhou, Chunfu Yang

Keywords(s): AIDS, assay, blood-borne, CDC Docket Import, CDC Docket Import CDC Prosecuting, CGH-DGHA, DA4AXX, DA4XXX, DAXXXX, DEVELOPING, Diagnosis, diagnostic, DRUG, drug resistance, drug resistant, DXXXXX, EMERGING, EPIDEMIOLOGIC, Genotype, Genotyping, Global, HIV, HIV-1, Listed LPM Houze as of 4/15/2015, PCR, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Resistance, RESISTANT, RT-PCR, Surveillance, therapeutic, tropical, viral, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Diagnostics

Simple, Field-Usable Fluorescence-Based Isothermal LAMP Assay for the On-Site Diagnosis of Malaria

CDC researchers have developed improved Loop-Mediated Isothermal Amplification (LAMP) assays for the nucleic acid-based diagnosis of malaria in field settings. The approach employs Plasmodium genus-specific LAMP primers and a portable tube scanner to run the LAMP reaction and measure fluorescence signal (e.g., SYBR green) as a measure of DNA amplification...

Published: 7/25/2024 | Inventor(s): Allison Demas, Naomi Lucchi, Venkatachalam Udhayakumar

Keywords(s): assay, Based, CDC Docket Import, CDC Docket Import CDC Prosecuting, CDCRM, DA2XXX, DAXXXX, DDXXXX, DEVELOPING, Development, Diagnosis, diagnostic, DXXXXX, Field-usable, Fluorescence, Isothermal, ivd, LAMP, LIMITED-RESOURCE, LOW INPUT, Malaria, Mosquito, Mosquitoes, nucleic acid, NUCLEIC ACID DETECTION, PCR ALTERNATIVE, real time, REAL-TIME, SIMPLE, travel, traveler, travelers, VBXXXX, Vector-borne, Vector-borne diseases, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WBXXXX, WDXXXX, WFXXXX, WIXXXX, WMXXXX, YBXXXX, Zoonotic

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Occupational Safety and Health, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Consumer Products

Multivalent, Multiple-Antigenic-Peptides for Serological Detection of HIV-1 Groups -M, -N, -O, and HIV-2

This CDC-developed invention pertains to multivalent antigenic peptides (MAPs) that can be used in a variety of HIV/AIDS diagnostics. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is subdivided into groups M, N, and O, while HIV-2 is subdivided into subtypes A and B. Within HIV -1 group M, several different subtypes and numerous forms of recombinant...

Published: 7/25/2024 | Inventor(s): Chou-Pong Pau

Keywords(s): 0, AAXXXX, AIDS, antibodies, ANTIGEN, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4AXX, DA4XXX, DAXXXX, Detection, DEVELOPING, DXXXXX, GROUP, HIV-1, HIV-2., LATERAL, M, MAPS, Multiple-antigenic-peptides, MULTIVALENT, N, RESEARCH MATERIAL, virus, VLXXXX, WBXXXX, WFXXXX, WIXXXX, XAXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, ResearchProducts > Antibodies, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Infectious Disease, Application > Occupational Safety and Health, Application > Therapeutics, Application > Consumer Products

Novel Rift Valley Fever Virus Vaccines

This invention relates to recombinant Rift Valley fever (RVF) viruses containing deletions in one or more virulence genes. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent RVF infection in livestock and humans. The recombinant RVF viruses grow to high titers, provide protective...

Published: 7/25/2024 | Inventor(s): Cesar Albarino, Stuart Nichol, Thomas Ksiazek, Brian Bird

Keywords(s): Biodefense, bioterrorism, Bioterrorist, CDC Docket Import, CDC Docket Import CDC Prosecuting, DB4BXX, DB4XXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DEVELOPING, DXXXXX, FEVER, Livestock, Method, methodology, Methods, Mosquito, Mosquitoes, OID-NCEZID-DHCPP, recombinant, Recombinant DNA, RIFT, rift valley, rift valley fever, rift valley fever virus, RVF, travel, traveler, travelers, tropical, Vaccine, Valley, VBXXXX, Vector, Vector-based, Vector-borne, Vector-borne diseases, VETERINARY, VETERINARY vaccine, viral, virus, Viruses, VLXXXX, VOXXXX, WAXXXX, WIXXXX, WMXXXX, XEXXXX, XHXXXX, YBXXXX, YCXXXX, Zoo, Zoonotic

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines, Application > Consumer Products, Application > Diagnostics, ResearchProducts > Research Equipment, Application > Research Materials

Human Rotavirus Strains and Vaccines for Neonatal Childhood Protection

This invention relates to rotavirus vaccine compositions and methods of vaccination. Rotaviral infection is the most commonly occurring gastrointestinal illness of children world, affecting both developed and developing economies. Additionally, rotavirus infections can affect livestock (especially calves and piglets), and resulting mortality/morbidity...

Published: 7/25/2024 | Inventor(s): Roger Glass, Yuhuan Wang, Jon Gentsch, Baoming Jiang

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, CHILDHOOD, Children, DB4BXX, DB4XXX, DBXXXX, DC5BXX, DC5XXX, DCXXXX, DEVELOPED, DEVELOPING, DIARRHEA, DXXXXX, Dysentery, GASTRIC, gastrointestinal, Human, Livestock, NEONATAL, Neonates, OID-NCIRD-DVD, rotavirus, Strain, STRAINS, Vaccine, VETERINARY, VETERINARY vaccine, viral, virus, VLXXXX, VOXXXX, WIXXXX, WJXXXX, WMXXXX, XEXXXX, XHXXXX, YBXXXX, YCXXXX, Zoo, Zoonotic

Category(s): Collaboration Sought > Licensing, Application > Research Materials, ResearchProducts > Research Equipment, Application > Vaccines, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Infectious Disease

Human Influenza Virus Real-time RT-PCR Detection and Characterization Panel

This invention relates to methods of rapidly detecting influenza, including differentiating between type and subtype. Unlike culture and serological tests requiring 5 to 14 days for completion, CDC researchers developed a rapid, accurate assay, which is easily adapted to kit form. This assay also requires less labor input than immunoassays. These...

Published: 7/25/2024 | Inventor(s): Alexander Klimov, Nancy Cox, Lamorris Loftin, Stephen Lindstrom

Keywords(s): Avian, Avian flu, Avian influenza, CDC, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4BXX, DA4XXX, DAXXXX, DDXXXX, Detection, DEVELOPED, DEVELOPING, Discriminate, discrimination, DXXXXX, INFLUENZA, PCR, PRIMERS, Probes, Pulmonary, respiratory, Respiratory Diseases, respiratory INFECTION, RT-PCR, Serotypes, SUBTYPES, Swine, tropical, Types, VETERINARY, viral, virus, Viruses, VLXXXX, VOXXXX, WBXXXX, WFXXXX, WMXXXX, XCXXXX, XEXXXX, YBXXXX, Zoo, Zoonotic

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Consumer Products, Application > Occupational Safety and Health, Application > Diagnostics, Application > Research Materials

Intranasal Dry Powder Inhaler for Improved Delivery of Vaccines and Therapeutics

This Intranasal Dry Powder Inhaler (DPI), developed with Creare, Inc., allows low-cost delivery of powder vaccines. Nasal delivery has numerous advantages compared to traditional injected vaccines, including: 1) safe, needle-less administration by minimally-trained staff or patient; 2) better protection due to mucosal and cross-protection; and 3) decreased...

Published: 7/25/2024 | Inventor(s): James Barry, Darin Knaus, Edward Moynihan, Eric Friets, Mark Bagley, Mark Papania

Keywords(s): AB1XXX, AB3FXX, AB3GXX, ABXXXX, Agents, AXXXXX, BACTERIA, Bacterial, BACTERIAL VACCINES, Biodefense, biosecurity, bioterrorism, Bioterrorist, CDC Docket Import, CDC Docket Import CDC Prosecuting, Child safety device, CHILDHOOD, Children, DB1XXX, DB2XXX, DB3XXX, DB4AXX, DB4BXX, DB4XXX, DB5XXX, DBXXXX, DC1XXX, DC2XXX, DC3XXX, DC4XXX, DC5XXX, DC6XXX, DCXXXX, Delivery, delivery system, DEVELOPED, DEVELOPING, DEVICE, Devices, Disposable, DISPOSAL, Dry, DXXXXX, Field, Field-usable, FUNGAL, Intranasal, MEASLES, NASAL, Needle, OID-NCIRD-DVD, Portable, POWDER, Prevention, respiratory, SAFETY, SELF-ADMINISTRATION, Single-use, System, therapeutic delivery, treatment, VACCINATION, Vaccinations, VACCINE DELIVERY, vaccines, VBXXXX, viral vaccine, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WKXXXX, WMXXXX, XDXXXX, YBXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Medical Devices, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Non-Medical Devices, Application > Consumer Products, Application > Therapeutics

Parvovirus B19 Codon Optimized Structural Proteins for Vaccine and Diagnostic Applications

Parvovirus B19 (B19V) is the only known pathogenic human parvovirus. Infection by this viral pathogen can cause transient aplastic crisis in individuals with high red cell turnover, pure red cell aplasia in immunosuppressed patients, and hydrops fetalis during pregnancy. In children, B19V most commonly causes erythema infectiosum, or fifth's disease....

Published: 7/25/2024 | Inventor(s): Neal Young, Sachiko Kajigaya, Ning Zhi

Keywords(s): Against, AgainstB19V, APPLICATION, B19V, BBXXXX, CAPSID, Cells, CODON, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DEVELOPING, DNA-based, DXXXXX, Erythema infectiosum, Fifth Disease, GENES, Human parvovirus B19 infection, Hydrops fetalis, Infection, Non-pennissive, OPTIMIZED, PARTICLE, Parvovirus antenatal infection, Patent Category - Biotechnology, Pure red cell aplasia, USAGE, vaccines, VIRUS-LIKE, VLP-and

Category(s): Collaboration Sought > Collaboration, Application > Vaccines, Application > Diagnostics, TherapeuticArea > Infectious Disease