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Therapeutic, Bifunctional Janus Microparticles with Spatially Segregated Surface Proteins and Methods of Production

CDC researchers have developed a fabrication process to create bifunctional microparticles displaying two distinct proteins that are spatially segregated onto a single hemispheric surface. At present, there is no described way of producing biological microparticles with two distinct types of separated proteins. Bifunctional Janus particles generated...

Published: 4/8/2024 | Inventor(s): David White, Jennifer Tang, Todd Sulchek

Keywords(s): AAXXXX, ABXXXX, Asymmetrical, AXXXXX, Bi-Functionalized, CAXXXX, CBXXXX, CCXXXX, CDC Docket Import, CDC Docket Import NP, CXXXXX, DAXXXX, DBXXXX, DDXXXX, DEXXXX, DXXXXX, IAXXXX, IBXXXX, ICXXXX, IXXXXX, Microparticles, PXXXXX, VAXXXX, VBXXXX, VCXXXX, VDXXXX, VEXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VJXXXX, VKXXXX, VLXXXX, VMXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WIXXXX, WJXXXX, WKXXXX, WMXXXX, XAXXXX, XCXXXX, XDXXXX, XFXXXX, XHXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Consumer Products, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Neurology, TherapeuticArea > Oncology, TherapeuticArea > Dental, Application > Therapeutics, TherapeuticArea > Endocrinology, Application > Vaccines, TherapeuticArea > Immunology, TherapeuticArea > Ophthalmology, TherapeuticArea > Infectious Disease, Application > Software / Apps, TherapeuticArea > Geriatrics, Application > Medical Devices, ResearchProducts > Research Equipment, Application > Diagnostics, ResearchProducts > Antibodies, Application > Research Materials

Intranasal Nebulizer with Disposable Drug Cartridge for Improved Delivery of Vaccines and Therapeutics

Intranasal delivery is a simple, inexpensive and needle-free route for administration of vaccines and therapeutics. This intranasal delivery technology, developed with Creare LLC., includes low-cost, disposable drug cartridges (DDCs) that mate with a durable hand-held device. The rechargeable-battery-powered device transmits ultrasonic energy to the...

Published: 7/25/2024 | Inventor(s): James Barry, Nabil Elkouh, Mark Bagley, Darin Knaus, Robert Trabka, Eric Friets, James Norris, Mark Papania

Keywords(s): AB1XXX, AB3FXX, AB3GXX, AB3XXX, AB4XXX, Able, ABXXXX, AC1XXX, ACXXXX, AEROSOL, AEROSOL-GENERATING, AEROSOLIZATION, Aerosolized, AEROSOLS, AXXXXX, BACTERIA, Bacterial, BACTERIAL VACCINES, CARTRIDGE, CDC, CDC Docket Import, CDC Docket Import CDC Prosecuting, Chamber, COOLING, DB1XXX, DB2XXX, DB3XXX, DB4XXX, DB5XXX, DBXXXX, DC1XXX, DC2XXX, DC3XXX, DC4XXX, DC5BXX, DC5XXX, DC6XXX, DCXXXX, Delivery, DEVICE, Devices, Disposable, DRUG, Drug Delivery, DXXXXX, FUNGAL, HAND, Having, INSERT, Intranasal, Methods, NASAL, NEBULIZER, NIOSH-PRL, OID-NCIRD-DVD, PLATFORM, Platforms, Pulmonary, respiratory, Respiratory Diseases, respiratory INFECTION, System, SYSTEMS, therapeutic, therapeutic delivery, Vaccine, VACCINE DELIVERY, Vaccine Design, VACCINE DEVELOPMENT, VBXXXX, viral, viral vaccine, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WFXXXX, WJXXXX, WKXXXX, WMXXXX, XDXXXX, YBXXXX, YCXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Occupational Safety and Health, Application > Medical Devices, Application > Diagnostics, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Ophthalmology, Application > Consumer Products, TherapeuticArea > Oncology

Intranasal Dry Powder Inhaler for Improved Delivery of Vaccines and Therapeutics

This Intranasal Dry Powder Inhaler (DPI), developed with Creare, Inc., allows low-cost delivery of powder vaccines. Nasal delivery has numerous advantages compared to traditional injected vaccines, including: 1) safe, needle-less administration by minimally-trained staff or patient; 2) better protection due to mucosal and cross-protection; and 3) decreased...

Published: 7/25/2024 | Inventor(s): James Barry, Darin Knaus, Edward Moynihan, Eric Friets, Mark Bagley, Mark Papania

Keywords(s): AB1XXX, AB3FXX, AB3GXX, ABXXXX, Agents, AXXXXX, BACTERIA, Bacterial, BACTERIAL VACCINES, Biodefense, biosecurity, bioterrorism, Bioterrorist, CDC Docket Import, CDC Docket Import CDC Prosecuting, Child safety device, CHILDHOOD, Children, DB1XXX, DB2XXX, DB3XXX, DB4AXX, DB4BXX, DB4XXX, DB5XXX, DBXXXX, DC1XXX, DC2XXX, DC3XXX, DC4XXX, DC5XXX, DC6XXX, DCXXXX, Delivery, delivery system, DEVELOPED, DEVELOPING, DEVICE, Devices, Disposable, DISPOSAL, Dry, DXXXXX, Field, Field-usable, FUNGAL, Intranasal, MEASLES, NASAL, Needle, OID-NCIRD-DVD, Portable, POWDER, Prevention, respiratory, SAFETY, SELF-ADMINISTRATION, Single-use, System, therapeutic delivery, treatment, VACCINATION, Vaccinations, VACCINE DELIVERY, vaccines, VBXXXX, viral vaccine, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WKXXXX, WMXXXX, XDXXXX, YBXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Medical Devices, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Non-Medical Devices, Application > Consumer Products, Application > Therapeutics

Antigen-capture Electrochemiluminescent Assay for Determining Rabies Vaccine Potency

CDC researchers developed a more efficient method of assessing rabies vaccine potency using an antigen-capture electrochemiluminescent (ECL) assay. This assay utilizes SULFO-NHS-Ester labeled murine monoclonal antibodies to quantify glycoprotein concentration, which is an indicator of vaccine potency. Currently, the potency of rabies vaccines is determined...

Published: 7/25/2024 | Inventor(s): Charles Rupprecht

Keywords(s): AAXXXX, ABXXXX, AG1XXX, AG2XXX, AGXXXX, ANALYSES, assay, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DXXXXX, GLYCOPROTEIN, rabies, virus

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Infectious Disease, Application > Vaccines

Aortic Access from Vena Cava for Large Caliber Transcatheter Cardiovascular Interventions

The invention pertains to a device and method for transcatheter correction of cardiovascular abnormalities, such as the delivery of prosthetic valves to the heart. Featured is a device implant for closing a caval-aortic iatrogenic fistula created by the introduction of a transcatheter device from the inferior vena cava into the abdominal aorta. The...

Published: 7/25/2024 | Inventor(s): Ozgur Kocaturk, Robert Lederman

Keywords(s): AB3AXX, AB3CXX, AB3EXX, AB3FXX, AB3XXX, ABXXXX, Aortic, AXXXXX, Cardiovascular, Caval, mitral valve, PROSTHETIC, prosthetic device coating, Transcatheter

Category(s): Collaboration Sought > Collaboration

Diffusion Through Skull as Route of Delivery for Treatment of Brain Injury and Disease

Traumatic Brain injury (TBI) often results from head impact and is a major cause of death and disability. Brain injuries vary in severity and can be associated with hemorrhaging, swelling, inflammation, and death of brain tissue. Inventors at NINDS developed a novel approach to treating brain injuries that involves transcranial application of small...

Published: 7/25/2024 | Inventor(s): Theodore Roth, Dorian McGavern

Keywords(s): AB3DXX, AB3XXX, ABXXXX, AXXXXX, brain, Delivery, diffusion, Disease, INJURY, NB1JXX, NB1XXX, NBXXXX, NXXXXX, Route, Skull, TREATMENTS

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Neurology, Application > Therapeutics

Device for Non-Surgical Tricuspid Valve Annuloplasty

This is a non-surgical tricuspid annuloplasty to treat functional tricuspid valve regurgitation, meaning regurgitation with intact valve leaflets. The device is delivered using novel catheter techniques into the pericardial space and positioned along the atrioventricular groove. A compression member is positioned along the tricuspid annular free wall...

Published: 7/25/2024 | Inventor(s): Toby Rogers, Kanishka Ratnayaka, Robert Lederman

Keywords(s): AB2XXX, AB3CXX, AB3EXX, AB3FXX, AB3GXX, AB3XXX, ABXXXX, Annuloplasty, AXXXXX, Cardiology, Cardiovascular, Intrapericardial, Regurgitation, Transauricular, Tricuspid, Valve

Category(s): Collaboration Sought > Collaboration

Encircling Suture Delivery System

The invention provides a novel delivery system for delivering an encircling suture which includes two separate hollow limbs held together at an articulation by the suture to be delivered. The suture can extend through the hollow limbs, which slide along the suture. The distal ends of the limbs can be compressed into a desired delivery shape that allows...

Published: 7/25/2024 | Inventor(s): Merdim Sonmez, Dominigue Franson, Robert Lederman, Ozgur Kocaturk, Toby Rogers

Keywords(s): AB3CXX, AB3FXX, AB3XXX, ABXXXX, AXXXXX, Circumferencial, Encircling, Suture, System

Category(s): Collaboration Sought > Licensing

Intra-bone Drug Delivery Device and Method

The invention pertains to devices for directly infusing cellular therapeutics into patient bone. The device monitors intra-bone pressure using pressure sensors disposed at its proximal end and adjusts infusion pressures during infusion such that intra-bone pressure does not exceed levels of systemic blood pressure. Such devices, apparatus and methods...

Published: 7/25/2024 | Inventor(s): Robert Hoyt, Timothy Hunt, Randall Clevenger, Omer Aras, Richard Childs, Jeremy Pantin

Keywords(s): AB2XXX, AB3FXX, AB3GXX, AB3XXX, ABXXXX, AXXXXX, DEVICE, Devices, Drug Delivery, Intrabone, PRESSURE, PRESSURE SENSOR, Pressure-mediated

Category(s): Collaboration Sought > Collaboration

Methods and Devices for Transcatheter Cerclage Annuloplasty

The invention relates to techniques and devices for cardiovascular valve repair, particularly annuloplasty techniques and devices in which tensioning elements are positioned to treat regurgitation of the mitral valve or tricuspid valve. More specifically, the technology pertains to a new device for myocardial septal traversal ("cerclage reentry") that...

Published: 7/25/2024 | Inventor(s): Robert Lederman

Keywords(s): AB3FXX, ABXXXX, Annuloplasty, AXXXXX, CAPTURE, Cerclage, DEVICE, Expandable, Mesh, Patent Category - Mech/Elect/Soft, TARGET, Transcatheter

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing

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