Search Results - cardiovascular

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Conformational Restriction of Cyanine Fluorophores in Far-Red and Near-IR Range

Abstract: Small molecule fluorescent probes are important tools in diagnostic medicine. Existing far-red and near-IR cyanine fluorophores (e.g. Cy5, Alexa 647, Cy7, ICG) are active in the far-red and near-range, but these agents suffer from modest quantum yields (brightness) which limit wide utility. It has been reported that the limited brightness...

Published: 4/8/2024 | Inventor(s): Martin Schnermann, Megan Michie

Keywords(s): CANCER, Cardiovascular, cyanine fluorophores, FACS, Fluorescence guided surgery, Fluorescent probes, gastrointestinal (GI), IMAGING, KIDNEY, Schnermann, super resolution microscopy

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, Application > Diagnostics, TherapeuticArea > Gastroenterology, TherapeuticArea > Nephrology

Aortic Access from Vena Cava for Large Caliber Transcatheter Cardiovascular Interventions

The invention pertains to a device and method for transcatheter correction of cardiovascular abnormalities, such as the delivery of prosthetic valves to the heart. Featured is a device implant for closing a caval-aortic iatrogenic fistula created by the introduction of a transcatheter device from the inferior vena cava into the abdominal aorta. The...

Published: 7/25/2024 | Inventor(s): Ozgur Kocaturk, Robert Lederman

Keywords(s): AB3AXX, AB3CXX, AB3EXX, AB3FXX, AB3XXX, ABXXXX, Aortic, AXXXXX, Cardiovascular, Caval, mitral valve, PROSTHETIC, prosthetic device coating, Transcatheter

Category(s): Collaboration Sought > Collaboration

Device for Non-Surgical Tricuspid Valve Annuloplasty

This is a non-surgical tricuspid annuloplasty to treat functional tricuspid valve regurgitation, meaning regurgitation with intact valve leaflets. The device is delivered using novel catheter techniques into the pericardial space and positioned along the atrioventricular groove. A compression member is positioned along the tricuspid annular free wall...

Published: 7/25/2024 | Inventor(s): Toby Rogers, Kanishka Ratnayaka, Robert Lederman

Keywords(s): AB2XXX, AB3CXX, AB3EXX, AB3FXX, AB3GXX, AB3XXX, ABXXXX, Annuloplasty, AXXXXX, Cardiology, Cardiovascular, Intrapericardial, Regurgitation, Transauricular, Tricuspid, Valve

Category(s): Collaboration Sought > Collaboration

Magnetic Resonance Arterial Wall Imaging Methods that Compensate for Patient Aperiodic Intrinsic Cardiac, Chest Wall, and Blood Flow-Induced Motions

The technology includes MRI methods, systems, and software for reliably imaging vasculature and vascular wall thickness while compensating for aperiodic intrinsic motion of a patient during respiration. To overcome the loss of the orthogonality due to uncompensated residual motions and after a lapse of time equal to the trigger delay commenced at the...

Published: 7/25/2024 | Inventor(s): Ahmed Gharib, Roderic Pettigrew, Khaled Abd-Elmoniem

Keywords(s): AA3AXX, AA3XXX, AAXXXX, AD3XXX, ADXXXX, Angiographic, ANGIOGRAPHY, ARTERIAL, ARTERIOSCLEROSIS, AXXXXX, Cardiac, CARDIOCIRULATORY, Cardiovascular, MRI, VASCULATURE, Vasculture

Category(s): Collaboration Sought > Collaboration

Selective 12-Human Lipoxygenase Inhibitors for the Treatment of Diabetes and Clotting

This invention discloses small molecule inhibitors of human 12-lipoxygenase (12-hLO). 12-lipoxygenase expression, activation, and lipid metabolites have been implicated in type 1 and type 2 diabetes, cardiovascular disease, hypertension, Alzheimer’s, and Parkinson’s disease. The development of 12-hLO inhibitors may be a potent intracellular approach...

Published: 7/25/2024 | Inventor(s): Jerry Nadler, Michael Holinstat, Anton Simeonov, Ajit Jadhav, Theodore Holman, David Maloney

Keywords(s): 12-human, Cardiovascular, CAUSED, Clot, DIABETES, Discovery, Disease, Formation, IA1AXX, IA1XXX, IAXXXX, Inhibitors, IXXXXX, LIPOXYGENASE, Platelet-mediated, Prevention, SELECTIVE, treatment

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Cardiology, Application > Therapeutics, Application > Diagnostics

Three-Dimensional Curved Catheter for Right Atrial Appendage Traversal

Available for licensing and commercial development is a three-dimensionally configured curved catheter for safe traversal of the right atrial appendage (RAA). The device is configured to optimize one-way access of the pericardial space through the right atrium and into the RAA reducing the risk of coronary lacerations. Specifically the curved catheter...

Published: 7/25/2024 | Inventor(s): Toby Rogers, Nasser Rafiee, Adam Greenbaum, William O'Neill, Robert Lederman

Keywords(s): AB3CXX, AB3EXX, AB3FXX, AB3GXX, AB3XXX, Cardiovascular, catheter, Listed LPM Shmilovich as of 4/15/2015, Pericardial, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, VDXXXX, WMXXXX, XDXXXX, YAXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Consumer Products, TherapeuticArea > Cardiology, Application > Non-Medical Devices, Application > Medical Devices

Novel Roles of a DNA Repair Protein, DNA-PKcs, in Obesity, Neurological Function, and Aging

The catalytic subunit of the DNA-dependent protein kinase complex (DNA-PKcs) has been shown to be important in DNA repair and VDJ recombination in lymphocytes. The inventors have discovered that DNA-PKcs also plays novel, important roles in energy regulation and neurological function. The inventors observed that mature DNA-PKcs-deficient mice (also...

Published: 7/25/2024 | Inventor(s): Jay Chung

Keywords(s): Aging, ANXIETY, Cardiovascular, depression, DIABETES, DNA-Dependent, DNA-PKcs, Endurance, Energy, HEART, IB1XXX, IB3XXX, IB6XXX, IBXXXX, Inflammation, insulin, INSULIN-DEPENDENT, IXXXXX, LEARNING, MEMORY, METABOLIC, Metabolism, Mitochondria, Neurological, OBESITY, REGULATION, TYPE-2, Weight

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Cardiology, TherapeuticArea > Reproductive Health, TherapeuticArea > Immunology