Search Results - schnermann

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Coumarin Luciferins and Mutant Luciferases for Bioluminescence Imaging

Summary: Researchers at UCI and NCI seek licensing to adopt new applications for a family of far-red to near-infrared emission coumarin-based luciferins (CouLuc) with complementary mutant enzymes. Description of Technology: Bioluminescence imaging with luciferin-luciferase pairs is a well-established technique for tracking cells and other biological...

Published: 4/24/2026 | Updated: 8/2/2023 | Inventor(s): Martin Schnermann, Donald Caldwell, Jennifer Prescher, Zi Wei Yao, Anna Love

Keywords(s): CouLuc, Luciferases, Luciferins, Near-infrared, NIR, Optical Imaging, Schnermann

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Application > Therapeutics

Conformational Restriction of Cyanine Fluorophores in Far-Red and Near-IR Range

Abstract: Small molecule fluorescent probes are important tools in diagnostic medicine. Existing far-red and near-IR cyanine fluorophores (e.g. Cy5, Alexa 647, Cy7, ICG) are active in the far-red and near-range, but these agents suffer from modest quantum yields (brightness) which limit wide utility. It has been reported that the limited brightness...

Published: 4/22/2025 | Updated: 8/2/2023 | Inventor(s): Martin Schnermann, Megan Michie

Keywords(s): CANCER, Cardiovascular, cyanine fluorophores, FACS, Fluorescence guided surgery, Fluorescent probes, gastrointestinal (GI), IMAGING, KIDNEY, Schnermann, super resolution microscopy

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, Application > Diagnostics, TherapeuticArea > Gastroenterology, TherapeuticArea > Nephrology