Search Results - martin+schnermann

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Cancer Therapeutic Based on Hypoxia Inducible Factor 1 (HIF-1) Inhibitors

Abstract: Hypoxia is a characteristic of many solid tumors resulting from accelerated cellular proliferation and inadequate vascularization. HIF-1 is a transcription factor critical for maintaining cellular homeostasis in, and adaptively responding to, low oxygen environments. HIF-1 becomes activated through binding to the transcriptional co-activator...

Published: 4/8/2024 | Inventor(s): Kirk Gustafson, Martin Schnermann, Susanna Chan, Paresma Patel, William Figg, James McMahon

Keywords(s): CANCER, Hypoxia Inhibitor, Malaria, small molecule

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics

Coumarin Luciferins and Mutant Luciferases for Bioluminescence Imaging

Abstract: Bioluminescence imaging with luciferin-luciferase pairs is a well-established technique for tracking cells and other biological features in animal models. Bioluminescent is a chemical process which does not require an external input for excitation. Bioluminescent imaging is often limited to monitoring single processes in vivo due to the lack...

Published: 4/8/2024 | Inventor(s): Martin Schnermann, Donald Caldwell, Jennifer Prescher, Zi Wei Yao, Anna Love

Keywords(s): CouLuc, Luciferases, Luciferins, Near-infrared, NIR, Optical Imaging, Schnermann

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Application > Therapeutics

Conformational Restriction of Cyanine Fluorophores in Far-Red and Near-IR Range

Abstract: Small molecule fluorescent probes are important tools in diagnostic medicine. Existing far-red and near-IR cyanine fluorophores (e.g. Cy5, Alexa 647, Cy7, ICG) are active in the far-red and near-range, but these agents suffer from modest quantum yields (brightness) which limit wide utility. It has been reported that the limited brightness...

Published: 4/8/2024 | Inventor(s): Martin Schnermann, Megan Michie

Keywords(s): CANCER, Cardiovascular, cyanine fluorophores, FACS, Fluorescence guided surgery, Fluorescent probes, gastrointestinal (GI), IMAGING, KIDNEY, Schnermann, super resolution microscopy

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, Application > Diagnostics, TherapeuticArea > Gastroenterology, TherapeuticArea > Nephrology

A New Class of Stable Heptamethine Cyanine Fluorophores and Biomedical Applications Thereof

Abstract: Heptamethine cyanines are among the most widely used near-IR fluorophores. The near-IR range (between about 650 nm and 900 nm) is very useful for imaging applications due to the absence of background autofluorescence. Despite extensive use, many of these fluorophores suffer from chemical instability. Specifically, most of the current and commonly...

Published: 4/8/2024 | Inventor(s): Martin Schnermann, Roger Nani, James Shaum

Keywords(s): Antibody labeling, DYE, Fluorescence-activated cell sorting (FACS), Fluorophore, Heptamethine Cyanines, IMAGING, Imaging Microscopy, Imaging reagent, MICROSCOPY, near-IR fluorophores, Optical-Guided Surgery

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials, Collaboration Sought > Collaboration

Near-IR Light-Cleavable Antibody Conjugates and Conjugate Precursors

Abstract: This invention describes a general way to trigger the release of a bioactive small molecule from a targeting antibody. The key “trigger” is a fluorescent linker that is chemically disassembled upon irradiation with light in the near-IR range (~800 nm). This linker technology is a dramatic step forward for the field. The molecules can be tracked...

Published: 4/8/2024 | Inventor(s): Martin Schnermann, Alexander Gorka, Hisataka Kobayashi, Roger Nani

Keywords(s): ADC, Antibody-drug Conjugate, Chemical linkers, Fluorescent linker, PDT, personalized medicine, Photodynamic therapy, Targeted drug release, Targeted therapy

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics

Removal of Selected Proteins Using Light Energy: Photoimmunotherapy

Abstract: Researchers at the NCI Laboratory of Molecular Theranostics and the Molecular Imaging Program have developed a new method to modify, isolate and remove a single chemically-labeled molecule or a cluster of proteins associated with the chemically-labeled protein. The chemical label can be an antigen-antibody complex. This discovery is based...

Published: 4/8/2024 | Inventor(s): Hisataka Kobayashi, Martin Schnermann, Peter Choyke

Keywords(s): AGGREGATION, Fluorophore, IR700, photoactivation, Photoimmunotherapy

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Collaboration Sought > Collaboration, TherapeuticArea > Oncology