Search Results - peter+choyke

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Combination of Near Infrared Photoimmunotherapy Targeting Cancer Cells and Host-Immune Activation

Abstract: Common methods of cancer therapy largely rely on either direct killing of cancer cells or activation of the host immune response to do so, but not both. A recently developed treatment of tumors uses an antibody/photo-absorber, Ab-IR700, with near infrared photoimmunotherapy (NIR-PIT), to selectively kill IR700-bound and NIR-light-exposed cancer...

Published: 9/19/2024 | Inventor(s): Hisataka Kobayashi, Peter Choyke

Keywords(s): antibody-IR700, Combination Therapy, Immunomodulators, Immunotherapy, Kobayashi, Metastasis, Near-Infrared Photo Immunotherapy, NIR-PIT, Photochemical, Tumor Inhibition

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

89Zr-Oxine Complex for In Vivo PET Imaging of Labelled Cells and Associated Methods

Abstract: This technology from the NCI Molecular Imaging Program relates to a Zirconium-89 (89Zr)-oxine complex for cell labeling, tracking of labeled cells by whole-body positron emission tomography/computed tomography (PET/CT) imaging, and associated methods. A long half-life of 89Zr (78.4 hours), high sensitivity of PET, and absence of background...

Published: 4/8/2024 | Inventor(s): Noriko Sato, Haitao Wu, Gary Griffiths, Peter Choyke

Keywords(s): 89Zr, cell labeling, Oxine, zirconium-89

Category(s): Application > Research Materials, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology

Computer-Aided Diagnostic for Use in Multiparametric MRI for Prostate Cancer

Abstract: Multiparametric MRI improves image detail and prostate cancer detection rates compared to standard MRI. Computer aided diagnostics (CAD) used in combination with multiparametric MRI images may further improve prostate cancer detection and visualization. The technology, developed by researchers at the National Institutes of Health Clinical...

Published: 4/8/2024 | Inventor(s): Nathan Lay, Yohannes Tsehay, Ronald Summers, Ismail Turkbey, Ruida Cheng, Holger Roth, Matthew Mcauliffe, Sonia Gaur, Francessa Mertan, Peter Choyke, Matthew Greer

Keywords(s): Computer-aided Diagnostic, Image Analysis System/Software, National Institutes of Health Clinical Center, NIHCC

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Software / Apps, TherapeuticArea > Oncology

Removal of Selected Proteins Using Light Energy: Photoimmunotherapy

Abstract: Researchers at the NCI Laboratory of Molecular Theranostics and the Molecular Imaging Program have developed a new method to modify, isolate and remove a single chemically-labeled molecule or a cluster of proteins associated with the chemically-labeled protein. The chemical label can be an antigen-antibody complex. This discovery is based...

Published: 4/8/2024 | Inventor(s): Hisataka Kobayashi, Martin Schnermann, Peter Choyke

Keywords(s): AGGREGATION, Fluorophore, IR700, photoactivation, Photoimmunotherapy

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Collaboration Sought > Collaboration, TherapeuticArea > Oncology