Search Results - metastasis

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Combination of Near Infrared Photoimmunotherapy Targeting Cancer Cells and Host-Immune Activation

Abstract: Common methods of cancer therapy largely rely on either direct killing of cancer cells or activation of the host immune response to do so, but not both. A recently developed treatment of tumors uses an antibody/photo-absorber, Ab-IR700, with near infrared photoimmunotherapy (NIR-PIT), to selectively kill IR700-bound and NIR-light-exposed cancer...

Published: 4/8/2024 | Inventor(s): Hisataka Kobayashi, Peter Choyke

Keywords(s): antibody-IR700, Combination Therapy, Immunomodulators, Immunotherapy, Kobayashi, Metastasis, Near-Infrared Photo Immunotherapy, NIR-PIT, Photochemical, Tumor Inhibition

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

Antisense Oligonucleotides against Cancer Cell Migration and Invasion

Abstract: Advanced stage cancers are typically marked by metastases of the primary cancer to secondary sites such as lungs, liver, and bones. Such metastatic cancers result in strikingly low 5-year survival rates, underscoring the need for novel therapeutics. For example, bone metastasis of primary breast cancer has a 5-year survival rate of 13%, lung...

Published: 4/8/2024 | Inventor(s): Stavroula Mili

Keywords(s): Antisense, APC, CANCER, Invasion, Metastasis, MIGRATION, Mili, Net1, OLIGO, oligonucleotide, Oncology, Rab13, RNA

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics

Assay to Screen Anti-metastatic Drugs

Abstract: Scientists at the NCI developed a research tool, a murine cell line model (JygMC(A)) with a reporter construct, of spontaneous metastatic mammary carcinoma that resembles the human breast cancer metastatic process in a triple negative mammary tumor. The assay is useful for screening compounds that specifically inhibit pathways involved in...

Published: 8/13/2024 | Inventor(s): Nadia Castro, David Salomon, Frank Cuttitta

Keywords(s): ANGIOGENESIS, Cell line, Metastasis, Triple Negative Breast Cancer, tumorigenesis

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials

3-o-sulfo-galactosylceramide Analogs as Activators of Type II Natural Killer T (NKT) Cells to Reduce Cancer Metastasis to the Lung

Abstract: Lung metastases are a sign of widespread cancer with poor survival rate. Lung malignancies can originate from almost any cancer type spread via the blood stream. Most common lung metastases are from melanoma, breast cancer, bladder cancer, colon cancer, prostate cancer, neuroblastoma, and sarcoma. Living more than 5 years with lung metastases...

Published: 8/5/2024 | Inventor(s): Lise Pasquet, Jay Berzofsky, Amy Howell, Masaki Terabe, Kaddy Camara

Keywords(s): 3-o-sulfo-galactosylceramide Analogs, Berzofsky, C24:2, Immunotherapy, lung cancer, Metastasis, Natural Killer cells, NKT cells, Sulfatide Analogs, T Cells

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Immunology

Genetically Modified Hematopoietic Stem And Progenitor Cells (HSPCs) And Mesenchymal Cells As A Platform To Reduce Or Prevent Metastasis, Treat Autoimmune And Inflammatory Disorders, And Rebalance The Immune Milieu And Dysregulated Niches

Abstract: Cancer cells can spread to various regions in the body in a process called metastasis which is associated with non-responsive to treatment and thus reduced survival. Identifying the markers of metastasis has been a major concern in the field of cancer diagnosis and therapy. Interestingly, research has shown that there is an increase in myeloid...

Published: 4/8/2024 | Inventor(s): Rosandra Kaplan, Sabina Kratzmeier, Daneil Beury, Haiying Qin

Keywords(s): adoptive cell therapy, AUTOIMMUNE DISEASE, Cancer Immunotherapy, GEMys, Genetically Engineered Myeloid Cells, Kaplan, Metastasis, Platform Technology

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology

Genetically Engineered Mouse-Derived Allograft for Preclinical Studies of Metastatic Melanoma

Abstract: The invention listed below is owned by an agency of the U.S. Government and is available for licensing and/or co-development in the U.S. in accordance with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious commercialization of results of federally-funded research and development. Before testing drugs in humans, drug developers are required...

Published: 5/23/2024 | Inventor(s): Chi-Ping Day, Glenn Merlino, Zoe Ohler, Rajaa El Meskini, Terry Van Dyke, Thomas Tuting

Keywords(s): Allograft, GDA, Genetically Engineered Mouse-Derived Allograft, MELANOMA, Metastasis, mouse model, Preclinical, therapeutics

Category(s): Application > Research Materials, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology

The UBE2G2 Binding Domain in the Ubiquitin Ligase GP78 and Methods of Use Thereof

Abstract: Cancer is the second leading cause of death worldwide. The primary cause of mortality from cancer is metastasis. While the underlying mechanisms of cancer metastasis are still being unraveled, the gp78 protein involved in ER-associated degradation (ERAD) appears to play a role in metastasis in sarcoma. Targeting gp78 may be a therapeutic option...

Published: 4/8/2024 | Inventor(s): Allan Weissman, Jennifer Mariano, Bo Chen, Yien-Che Tsai

Keywords(s): APOPTOSIS, CANCER, Endoplasmic Reticulum, er, ERAD, ER-associated Degradation, Gp78, Metastasis, STRESS, Ube2G2, Ubiquitin, Weissman

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Collaboration

Non-toxic Compounds that Inhibit the Formation and Spreading of Tumors

Available for licensing are novel pyrrolopyrimidine compounds that disrupt the assembly of the perinucleolar compartment (PNC), a sub-nuclear structure highly prevalent in metastatic tumors. These notable compounds act without overt cytotoxicity. The presence of the PNC positively correlates with metastatic capacity, making it a potential marker for...

Published: 7/25/2024 | Inventor(s): Samarjit Patnaik

Keywords(s): CB5EXX, CB5XXX, CBXXXX, CXXXXX, Metastasis, MODULATORS, Patent Category - Chemistry, PNC, small molecule, Tumorgenesis

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

Diagnostic Biomarker of Metastasis for Improved Clinical Management of Head and Neck Cancer

Squamous Cell Carcinoma of the Head and Neck (HNSCC) is associated with poor prognosis due to the advanced stage of disease (metastasis) typically found at the time of diagnosis. Investigators at the NIH have developed a sensitive method using a protein biomarker for detecting even just a few HNSCC tumor cells in lymph nodes with occult disease. Combination...

Published: 7/25/2024 | Inventor(s): J Silvio Gutkind

Keywords(s): Biomarker, CA1XXX, Carcinoma, squamous cell of head and neck, CAXXXX, CXXXXX, Detection, DSG3, Identification, lymph, MEN 1, Metastasis, nodes, OCCULT, Patent Category - Biotechnology, Sentinel, Squamous cell carcinoma, Squamous cell carcinoma of the head and neck, Zollinger-Ellison syndrome

Category(s): Application > Diagnostics, TherapeuticArea > Oncology