Search Results - cell+line

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Abstract: Scientists at the NCI developed a research tool, a murine cell line model (JygMC(A)) with a reporter construct, of spontaneous metastatic mammary carcinoma that resembles the human breast cancer metastatic process in a triple negative mammary tumor. The assay is useful for screening compounds that specifically inhibit pathways involved in...

Published: 8/13/2024 | Inventor(s): Nadia Castro, David Salomon, Frank Cuttitta

Keywords(s): ANGIOGENESIS, Cell line, Metastasis, Triple Negative Breast Cancer, tumorigenesis

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials

Target for Anti-Tumor Immune Responses

Abstract: The Surgery Branch of the National Cancer Institute is seeking statements of capability or interest from parties interested in collaborative research to carry out genotypic as well as phenotypic analysis of the 888 mel cell line in order to better understand the nature of tumor cells that respond to therapy. In addition, this cell line can...

Published: 4/8/2024 | Inventor(s): Steven Rosenberg, Suzanne Topalian

Keywords(s): 888-mel, CANCER, Cell line, MELANOMA

Category(s): Application > Research Materials, TherapeuticArea > Oncology, Collaboration Sought > Licensing

Reporter Assay for Detection and Quantitation of Replication-Competent Gammaretrovirus

Abstract: Gammaretroviral vectors were the first viral gene-therapy vectors to enter clinical trials and remain in use. One potential hazard associated with the use of such vectors is the presence of replication-competent retroviruses (RCR) in the vector preparations – either as a result of: 1) recombination events between the plasmids used for...

Published: 4/8/2024 | Inventor(s): Alan Rein, Amanda (Declined Royalty) Aloia

Keywords(s): Cell line, Gammaretrovirus, Gaussia Luciferase, GENE THERAPY, PLASMID, RCR, Rein, Replication-Competent Retrovirus, Vector Preparation

Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Immunology

Adriamycin-Resistant Ovarian Tumor Cell Line, NCI/ADR-RES

Abstract: Cancer cells may acquire drug resistance after prolonged chemotherapy. In many cases, cancer cells develop resistance to several drugs with distinct structures and modes of action. This multi-drug resistance phenomenon increases the complexity of cancer treatment. Researchers at the National Cancer Institute (NCI) have derived an Adriamycin-resistant...

Published: 4/8/2024 | Inventor(s): Kenneth Cowan

Keywords(s): ADENOCARCINOMA, Adriamycin-resistant, Cell line, Cowan, MCF-7/ADR-RES, MDR1, Multi-Drug Resistance, NCI/ADR-RES, OVARIAN CANCER, OVCAR-8, P-GLYCOPROTEIN

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology

Tni-FNL: An Improved Trichoplusia Ni Cell Line for Protein Expression

Abstract: Researchers at the National Cancer Institute (NCI) have developed an improved insect cell line, Tni-FNL, derived from the cabbage looper, Trichoplusia ni. The Tni-FNL cell line is capable of high level expression of heterologous proteins using baculovirus-based expression systems. When compared to commercially available cell lines used for...

Published: 5/22/2024 | Inventor(s): Dominic Esposito, Ralph (Butch) Hopkins, Veronica Roberts

Keywords(s): Baculovirus, Cell line, Esposito, Insect Cell, Protein Expression, Tni-FNL

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology

Stem Cell Factor-responsive FcepsilonRI Bearing Human Mast Cell Line LAD2

A human mast cell line LAD2 that more closely resembles normal in vivo and in vitro human mast cells by expressing functional FcepsilonRI receptors and responding to stem cell factor (SCF) with proliferation, as described in Leuk Res. 2003 Aug;27(8):677-82 and developed by the laboratory of Dr. Dean Metcalfe at the National Institute of Allergy and...

Published: 7/25/2024 | Inventor(s): Arnold Kirshenbaum, Cem Akin, Dean Metcalfe

Keywords(s): Cell line, IA3XXX, IAXXXX, IDXXXX, IXXXXX, Mast cell disease, Mastocytosis, RM, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Immunology