Search Results - baculovirus

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New Insect Sf9-ET Cell Line for Determining Baculovirus Titers

Abstract: The baculovirus-based protein expression system has gained increased prominence as a method for expressing recombinant proteins that are used in a wide range of biomedical applications. An important step in the use of this system is the ability to determine the virus infectious titer, i.e., the number of active baculovirus particles produced...

Published: 5/22/2024 | Inventor(s): Ralph (Butch) Hopkins, Dominic Esposito

Keywords(s): Baculovirus, Baculovirus Titer, Esposito, IMMUNE, Inflammation, Insect Cell Line, Protein Expression Sf9-ET

Category(s): TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, Collaboration Sought > Licensing, TherapeuticArea > Reproductive Health, TherapeuticArea > Nephrology, Application > Research Materials, TherapeuticArea > Gastroenterology, TherapeuticArea > Endocrinology, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Dermatology, TherapeuticArea > Immunology, TherapeuticArea > Oncology

Tni-FNL: An Improved Trichoplusia Ni Cell Line for Protein Expression

Abstract: Researchers at the National Cancer Institute (NCI) have developed an improved insect cell line, Tni-FNL, derived from the cabbage looper, Trichoplusia ni. The Tni-FNL cell line is capable of high level expression of heterologous proteins using baculovirus-based expression systems. When compared to commercially available cell lines used for...

Published: 5/22/2024 | Inventor(s): Dominic Esposito, Ralph (Butch) Hopkins, Veronica Roberts

Keywords(s): Baculovirus, Cell line, Esposito, Insect Cell, Protein Expression, Tni-FNL

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology

Bac-2-the-Future: An Improved System for Production of Recombinant Baculovirus

Abstract: Baculoviruses have been used for decades to produce proteins in insect cell hosts. Current systems for generating recombinant baculovirus have several shortcomings which prevent their easy use in high-throughput applications. Researchers within the Frederick National Laboratory for Cancer Research have developed an improved system called...

Published: 5/22/2024 | Inventor(s): Dominic Esposito, Carissa Grose

Keywords(s): B2F, Bac-2-the-Future, Baculovirus, Esposito, Insect Cells, Protein Production

Category(s): TherapeuticArea > Gastroenterology, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Reproductive Health, TherapeuticArea > Immunology, TherapeuticArea > Dermatology, Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Nephrology

Recombinant Baculoviruses Containing Inserts of the Major Structural Genes (vp1) of the Human Polyomaviruses JCV and BKV

The development of sensitive and specific tests for JC virus and BK virus activity may provide tools essential in the steps required to find a treatment for these fatal infections. This invention describes a Recombinant Vpl protein (rVp1) that can be used 1) as an antigen source for ELISA assays 2) for studies of viral proteins in cells and 3) for...

Published: 7/25/2024 | Inventor(s): Peter Jensen, Eugene Major

Keywords(s): Baculovirus, BKV, Containing, DA4BXX, DA4XXX, DAXXXX, DDXXXX, DXXXXX, GENES, Human, Inserts, JCV, MAJOR, Polyomavirus Infections, Polyomaviruses, recombinant, STRUCTURAL, VP1

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials