Search Results - jcv

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Methods for Prevention and Treatment of Polyomavirus Infection or Reactivation (E-179-2007)

Available for licensing and commercial development are methods of using Tranilast [N-(3',4'-dimethoxycinnamoyl)anthranilic acid] in the prevention and treatment of human polyomavirus infection. Treatment with Tranilast decreases viral protein expression for two human polyomavirus species, JC virus (JCV) and BK virus (BKV). Furthermore, the increase...

Published: 4/8/2024 | Inventor(s): Jeffrey Kopp, Eugene Major, Veerasamy Ravichandran

Keywords(s): BBXXXX, BK, BKV, DB4XXX, DBXXXX, DXXXXX, HIV AIDS, IMMUNOCOMPROMISED, Infection, inhibitor, JC, JCV, leukoencephalopathy, lymphoma, nephrophathy, PML, polyomavirus, Polyomavirus Infections, Polyomaviruses, Progressive multifocal leukoencephalopathy, TGF-B, Tranilast, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics

Recombinant Baculoviruses Containing Inserts of the Major Structural Genes (vp1) of the Human Polyomaviruses JCV and BKV

The development of sensitive and specific tests for JC virus and BK virus activity may provide tools essential in the steps required to find a treatment for these fatal infections. This invention describes a Recombinant Vpl protein (rVp1) that can be used 1) as an antigen source for ELISA assays 2) for studies of viral proteins in cells and 3) for...

Published: 7/25/2024 | Inventor(s): Peter Jensen, Eugene Major

Keywords(s): Baculovirus, BKV, Containing, DA4BXX, DA4XXX, DAXXXX, DDXXXX, DXXXXX, GENES, Human, Inserts, JCV, MAJOR, Polyomavirus Infections, Polyomaviruses, recombinant, STRUCTURAL, VP1

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials

Methods for Prevention and Treatment of Polyomavirus Infection or Reactivation

Available for licensing and commercial development are methods of using two MAP kinase kinase (MEK) inhibitors, PD98059 and U0126, in the prevention and treatment of polyomavirus infection. Decrease in viral protein expression upon treatment with the MEK inhibitors has been demonstrated for two polyomavirus species, JC virus (JCV) and BK virus (BKV)....

Published: 4/8/2024 | Inventor(s): Eugene Major, Veerasamy Ravichandran

Keywords(s): BBXXXX, BK, BKV, DB4BXX, DB4XXX, DBXXXX, DXXXXX, EFFECTOR, Idenitification, Infection, Infections;, inhibitor, Inhibitors, JC, JCV, lymphoma, MAP-kinase-, MEK, PD98059, Polyomavirus Infections, Progressive multifocal leukoencephalopathy, U0126, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics