Search Results - angiogenesis

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Abstract: Scientists at the NCI developed a research tool, a murine cell line model (JygMC(A)) with a reporter construct, of spontaneous metastatic mammary carcinoma that resembles the human breast cancer metastatic process in a triple negative mammary tumor. The assay is useful for screening compounds that specifically inhibit pathways involved in...

Published: 12/6/2024 | Inventor(s): Nadia Castro, David Salomon, Frank Cuttitta

Keywords(s): ANGIOGENESIS, Cell line, Metastasis, Triple Negative Breast Cancer, tumorigenesis

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials

Angiogenesis-Based Cancer Therapeutic

Abstract: Vascular Endothelial Growth Factor-A (VEGF-A) is an angiogenic agent that drives blood vessel formation in solid tumors and other diseases, such as macular degeneration and diabetic retinopathy. Several therapies that target the ability of VEGF to stimulate angiogenesis have been approved. These therapies regulate VEGF-A activity by binding...

Published: 4/8/2024 | Inventor(s): Donald Bottaro, Fabiola Cecchi

Keywords(s): ANGIOGENESIS, CHEMOTHERAPY, Diabetic Retinopathy, FLT-1, Heparin sulfate proteoglycan, Hepatocyte growth factor (HGF), KDR/FLK-1, Macular degeneration, VEGF-A

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Licensing