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Reporter Assay for Detection and Quantitation of Replication-Competent Gammaretrovirus

Abstract: Gammaretroviral vectors were the first viral gene-therapy vectors to enter clinical trials and remain in use. One potential hazard associated with the use of such vectors is the presence of replication-competent retroviruses (RCR) in the vector preparations – either as a result of: 1) recombination events between the plasmids used for...

Published: 4/8/2024 | Inventor(s): Alan Rein, Amanda (Declined Royalty) Aloia

Keywords(s): Cell line, Gammaretrovirus, Gaussia Luciferase, GENE THERAPY, PLASMID, RCR, Rein, Replication-Competent Retrovirus, Vector Preparation

Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Immunology