Search Results - t+cells

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Methods of Producing Thymic Emigrants from Induced Pluripotent Stem Cells

Abstract: Hematopoietic and pluripotent stem cells can be differentiated into T cells with potential clinical utility. Current approaches for in vitro T cell production rely on Notch signaling and artificial mimicry of thymic selection. However, these approaches result in unconventional or phenotypically aberrant T cells; which may lead to unpredictable...

Published: 4/8/2024 | Inventor(s): Raul Sakoda, Nicholas Klemen, Nicholas Restifo

Keywords(s): DIFFERENTIATION, Induced Pluripotent Stem Cells, IPSCS, RESEARCH MATERIAL, Restifo, T Cells, Thymic Environment, Tool

Category(s): TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Licensing

A Dendritic Cell Vaccine to Immunize Cancer Patients Against Mutated Neoantigens Expressed by the Autologous Cancer

Abstract: Vaccines against non-viral cancers target mainly differentiation antigens, cancer testis antigens, and overexpressed antigens. One common feature to these antigens is their presence in central immunological tolerance. Using these vaccines, T cells underwent depletion of high avidity clones directed against such antigens. This depletion can...

Published: 4/8/2024 | Inventor(s): Gal Cafri, Paul Robbins, Jared Gartner, Steven Rosenberg

Keywords(s): CANCER, Dendritic cells, Immunotherapy, Neoantigens, Rosenberg, T Cells, vaccines

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Vaccines

In vitro Generation of an Autologous Thymic Organoid from Human Pluripotent Stem Cells

Abstract: The thymus is an integral part of the adaptive immune system as it generates T cells. Its function diminishes rapidly as the body ages, leading to a compromise of the immune system in the elderly. Reconstitution of adaptive immunity through mass production of different T cell types is therefore a therapeutic need in immunocompromised populations....

Published: 4/8/2024 | Inventor(s): Raul Sakoda, Nicholas Restifo

Keywords(s): Aging, IMMUNOCOMPROMISED, Immunotherapy, Natural Killer T Cells, NKT, Organogenesis, Organoid, Pluripotent Stem Cells, T Cells, THYMUS, Vizcardo

Category(s): Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Immunology, Collaboration Sought > Licensing

3-o-sulfo-galactosylceramide Analogs as Activators of Type II Natural Killer T (NKT) Cells to Reduce Cancer Metastasis to the Lung

Abstract: Lung metastases are a sign of widespread cancer with poor survival rate. Lung malignancies can originate from almost any cancer type spread via the blood stream. Most common lung metastases are from melanoma, breast cancer, bladder cancer, colon cancer, prostate cancer, neuroblastoma, and sarcoma. Living more than 5 years with lung metastases...

Published: 8/5/2024 | Inventor(s): Lise Pasquet, Jay Berzofsky, Amy Howell, Masaki Terabe, Kaddy Camara

Keywords(s): 3-o-sulfo-galactosylceramide Analogs, Berzofsky, C24:2, Immunotherapy, lung cancer, Metastasis, Natural Killer cells, NKT cells, Sulfatide Analogs, T Cells

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Immunology

Improved Personalized Cancer Immunotherapy

Abstract: Scientists at NIH have identified a process to select highly tumor-reactive T cells from a patient tumor sample based on the expression of four specific T cell surface markers: programmed cell death protein 1 (PD-1; CD279), 4-1BB (CD137), T cell lg-and mucin-domain-containing molecule-3 (TIM-3), and/or lymphocyte activation gene 3 (LAG-3)....

Published: 4/8/2024 | Inventor(s): Alena Gros, Steven Rosenberg

Keywords(s): adoptive cell transfer (ACT), T Cells, tumor infiltrating leukocytes (TIL)

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

Tethered Interleukin-15 (IL-15)/IL-21 to Enhance T Cells for Cellular Therapy

Abstract: Interleukin-15 (IL-15) and IL-21 have been reported to support the function of anti-tumor T cells. However, their use in the clinic has been constrained, in part, by dose-limiting toxicity and the need for repeated administration. To overcome these limitations, researchers in the National Cancer Institute (NCI) Experimental Transplantation...

Published: 4/8/2024 | Inventor(s): Christian Hinrichs, Benjamin Jin

Keywords(s): act, adoptive cell therapy, CANCER, CAR, chimeric antigen receptor, Hinrichs, IL-15, IL-21, INTERLEUKIN-15, Interleukin-21, T Cells

Category(s): TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing