Search Results - differentiation

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Methods of Producing Thymic Emigrants from Induced Pluripotent Stem Cells

Abstract: Hematopoietic and pluripotent stem cells can be differentiated into T cells with potential clinical utility. Current approaches for in vitro T cell production rely on Notch signaling and artificial mimicry of thymic selection. However, these approaches result in unconventional or phenotypically aberrant T cells; which may lead to unpredictable...

Published: 4/8/2024 | Inventor(s): Raul Sakoda, Nicholas Klemen, Nicholas Restifo

Keywords(s): DIFFERENTIATION, Induced Pluripotent Stem Cells, IPSCS, RESEARCH MATERIAL, Restifo, T Cells, Thymic Environment, Tool

Category(s): TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Licensing

Novel Methods for Generating Retinal Pigment Epithelium Cells from Induced Pluripotent Stem Cells

Abstract: The retinal pigment epithelial cells (RPE) make up a polarized monolayer in the vertebrate eye that separates the neural retina from the choroid, and performs a crucial role in retinal physiology by forming a blood-retinal barrier and closely interacting with photoreceptors to maintain visual function. Many ophthalmic diseases, such as age-related...

Published: 4/8/2024 | Inventor(s): Kapil Bharti, Kapil Bharti, Janine Davis, Sheldon Miller, Arvydas Maminishkis, Marc Ferrer-Alegre

Keywords(s): Age-related Macular Degeneration, AMD, DIFFERENTIATION, retinal pigment epithelial cells, STEM CELLS

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Collaboration Sought > Collaboration, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat

Rapid and Robust Differentiation of Human iPSCs into Motor Neurons

This technology includes a system that allows for robust differentiation of human-induced pluripotent stem cells (iPSC) into motor neurons within a time frame of 7 to 10 days. To differentiate the iPSC, a stable transgene is inserted into the CLYBL safe harbor locus in the human genome using TALENs. The transgene allows for doxycycline-inducible expression...

Published: 7/25/2024 | Inventor(s): Michael Ward, Christopher Grunseich

Keywords(s): DIFFERENTIATION, Factor-Medeated, Human, iPSC, MOTOR, Neurons, transcription, VPXXXX, WIXXXX, XEXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, Application > Research Materials

Improved Culture Medium for Stem Cell Maintenance and Differentiation

A novel low protein culture medium with defined chemical components that allows pluripotent stem cell maintenance and differentiation is disclosed. The present technology also provides for production of high quality cardiac cells from human embryonic and induced pluripotent stem cells in chemically defined medium conditions. Human pluripotent stem...

Published: 7/25/2024 | Inventor(s): Yongshun Lin, Guokai Chen

Keywords(s): AC5XXX, ACXXXX, ADDITIVES, AXXXXX, Cell, Chemically, CM-dextran, CULTURE, DEFINED, DIFFERENTIATION, GLYCOGEN, HEPARIN, Human, IMPROVING, Lipid, Maintenance, Medium, Pluripotent, RXXXXX, Stem, Trehalose

Category(s): Collaboration Sought > Collaboration, Application > Research Materials

Use of Vitronectin as a Biomarker for the Detection of Dengue Hemorrhagic Fever

Dengue hemorrhagic fever (DHF) is a severe, potentially deadly infection spread by mosquitos. CDC scientists have identified vitronectin as an important biomarker of DHF. They have shown vitronectin is significantly reduced in DHF and severe dengue infections when compared to dengue non-hemorrhagic fever patients. Presently, DHF is established by assessing...

Published: 7/25/2024 | Inventor(s): Momar Ndao, Kay Tomashek, Betty Poole-Smith, Elizabeth Hunsperger

Keywords(s): assay, Biomarker, DA4BXX, DA4XXX, DAXXXX, DENGUE, Detection, diagnostic, DIFFERENTIATION, DXXXXX, FEVER, HEMORRHAGIC, HOST, UB1XXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics, TherapeuticArea > Infectious Disease

A Nurr1-Knockout Mouse Model for Parkinson's Disease and Stem Cell Differentiation

The researchers have generated Nurr1-knockout mice via genomic locus inactivation using homologous recombination. Transcription factor Nurr1 is an obligatory factor for neurotransmitter dopamine biosynthesis in ventral midbrain. From a neurological and clinical perspective, it suggests an entirely new mechanism for dopamine depletion in a region where...

Published: 4/8/2024 | Inventor(s): Vera Nikodem

Keywords(s): AC5XXX, ACXXXX, Affected, AS..., AXXXXX, BAXXXX, BIOSYNTHESIS, DIFFERENTIATION, Disease, Dopamine, DOPAMINERGIC, ESSENTIAL, factor, Midbrain, Neurons, NEUROTRANSMITTER, Nurr1, Obligatory, Parkinson disease 2, Parkinson disease 3, Parkinson disease 9, Parkinson disease, juvenile, autosomal recessive, Parkinsons, Region, TERMINAL, transcription, VENTRAL

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, ResearchProducts > Animal Models