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Mouse Model and Derived Cells That Hypersecrete Leukemia Inhibitory Factor (LIF)
Embryonic stem cells (ESCs) are pluripotent cells that can be cultured indefinitely, and maintain their capability to differentiate into all cell lineages. To maintain these cells as well as various types of related induced stem cells and progenitor cells in culture, Mouse Embryonic Fibroblasts (MEFs) are routinely used as feeder cells, largely to serve...
Published: 7/25/2024   |   Inventor(s): Perry Blackshear
Keywords(s): BAXXXX, CC3XXX, CCXXXX, Cells, CXXXXX, DERIVED, factor, HypersecreteLeukemia, INHIBITORY, Knock-in, LIF., Mice, RXXXXX, That
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, TherapeuticArea > Oncology, ResearchProducts > Animal Models
New Mouse Strain with Conditional Deletion of SMAD7: Analysis of Disease Processes Involving Immunological, Fibrotic or Cardiovascular Indications
SMAD7 conditional knockout mice are available for licensing. SMAD7 can be knocked out by breeding with CRE-recombinase transgenic mice with a variety of promoters to yield tissue or cell type-specific deletions of SMAD7. SMAD7 has been shown to play a role in bone morphogenesis, cardiovascular tissue generation, immune regulation and fibrosis. Therefore,...
Published: 7/25/2024   |   Inventor(s): Marilyn Diaz
Keywords(s): BAXXXX, Chromosome 7, monosomy, Conditional, Deletion, Deletion 7, Gene., Mouse, RXXXXX, Scleroderma, Scleroderma, systemic, SMAD7, Strain
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials, ResearchProducts > Animal Models
T-Cell-Specific Gfi-1 Knockout Mouse
This is a mouse model available to study T-cell differentiation. Growth factor independent 1 (GFi-1) is a transcriptional repressor that is transiently induced during T-cell activation. This knockout mouse line is a GFi-1[flox/flox] introduced into a mouse Cre controlled by a CD4 promoter, which allows selective removal of GFi-1 exclusively in T-cells....
Published: 7/25/2024   |   Inventor(s): William Paul (Estate Of), Jinfang (Jeff) Zhu
Keywords(s): BAXXXX, Cells, FUNCTION, Gfi-1, Gfi1[fl/fl]-CD4Cre, IMPORTANT, KO, Mouse, Regulatory, REVEALS, RXXXXX, Specific, Strain, T, T-cell
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials, ResearchProducts > Animal Models
Transgenic Mice with Conditionally-Enhanced Bone Morphogen Protein (BMP) Signaling: A Model for Human Bone Diseases
This technology relates to novel animal models of several human bone diseases that have been linked to enhanced BMP signaling. More specifically, this mouse model expresses a mutant receptor for BMP, known as Alk2 that is always actively signaling. This receptor is under the control of the Cre-loxP system, which allows control of expression of the...
Published: 7/25/2024   |   Inventor(s): Manas Ray, Gregory Scott, Yuji Mishina
Keywords(s): BAXXXX, BMP:, Bone, Craniosynostosis, Disease, Enhanced, Expressing, Fibrodysplasia ossificans progressiva, Human, IDXXXX, IXXXXX, Model, MORPHOGENETIC, Mouse, MULTIPLE MYELOMA, Protein, SIGNALING
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, ResearchProducts > Animal Models, Application > Diagnostics, Application > Research Materials
A Nurr1-Knockout Mouse Model for Parkinson's Disease and Stem Cell Differentiation
The researchers have generated Nurr1-knockout mice via genomic locus inactivation using homologous recombination. Transcription factor Nurr1 is an obligatory factor for neurotransmitter dopamine biosynthesis in ventral midbrain. From a neurological and clinical perspective, it suggests an entirely new mechanism for dopamine depletion in a region where...
Published: 4/8/2024   |   Inventor(s): Vera Nikodem
Keywords(s): AC5XXX, ACXXXX, Affected, AS..., AXXXXX, BAXXXX, BIOSYNTHESIS, DIFFERENTIATION, Disease, Dopamine, DOPAMINERGIC, ESSENTIAL, factor, Midbrain, Neurons, NEUROTRANSMITTER, Nurr1, Obligatory, Parkinson disease 2, Parkinson disease 3, Parkinson disease 9, Parkinson disease, juvenile, autosomal recessive, Parkinsons, Region, TERMINAL, transcription, VENTRAL
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, ResearchProducts > Animal Models
A Mouse with a Targeted Mutation in the Uncoupling Protein-3 (upc3) Gene
The NIH announces the development of a transgenic mouse with a targeted mutation in the ucp3 gene. The ucp3 gene is implicated I the function of regulating energy metabolism. This regulatory function is thought to be accomplished by changing metabolic efficiency (causing energy expended as heat rather than used for ADP/ATP conversion) and/or by participating...
Published: 4/8/2024   |   Inventor(s):  
Keywords(s): AC5XXX, ACXXXX, Animal Model, AXXXXX, BAXXXX, Gene, Mouse, MUTATION, Protein-3, Q fever, Targeted, UCP3, Uncoupling
Category(s): Collaboration Sought > Licensing, ResearchProducts > Animal Models
Tristetraprolin (TTP) Knockout Mice
National Institutes of Health researchers have developed knockout mice that do not express Tristetraprolin (TTP). TTP is an AU-rich element (ARE) binding protein and the prototype of a family of CCCH zinc finger proteins. AREs were identified as conserved sequences found in the 3’ untranslated region (3’ UTR) of a variety of transiently expressed...
Published: 7/25/2024   |   Inventor(s): Perry Blackshear
Keywords(s): AC5XXX, ACXXXX, AXXXXX, BAXXXX, CCXXXX, CXXXXX, IDXXXX, IXXXXX, KNOCK-OUT, Mouse, TTP
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Oncology, Application > Research Materials, Application > Therapeutics, Application > Diagnostics, ResearchProducts > Animal Models
Generation of Smad3-null Mice and Smad4-conditional Mice
SMADs are a novel set of mammalian proteins that act downstream of TGF-beta family ligands. These proteins can be categorized into three distinct functional sets, receptor-activated SMADs (SMADs 1,2,3,5, and 8), the common mediator SMAD (SMAD 4), and inhibitory SMADs (SMADs 6 and 7). SMAD proteins are thought to play a role in vertebrate development...
Published: 4/8/2024   |   Inventor(s): Chuxia Deng
Keywords(s): 3-@hydroxyacyl-coa dehydrogenase deficiency, BAXXXX, HAD deficiency, HIS deficiency, Histidinemia, IDXXXX, IXXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, ResearchProducts > Animal Models, Application > Research Materials, Application > Diagnostics
A Tet-Regulated Mouse Model for Cataract
Cataract is the most common cause of blindness worldwide, with an estimated 25 million blind and 119 million visually impaired individuals worldwide. Over 20 million adults in the US alone are currently diagnosed with cataracts making this disease a major health concern. The incidence of cataract increases with age and a number of etiologic factors...
Published: 7/25/2024   |   Inventor(s): Robert Sobol
Keywords(s): BAXXXX, IDXXXX, IXXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, ResearchProducts > Animal Models
A Mouse Model for Type 2 Diabetes
Diabetes affects over 120 million people worldwide (16 million in the US) and is a major health problem with associated health costs estimated at almost $100 billion dollars. Type 2 diabetes affects as many as 10% of the population of the Western World (with 15 million patients in the US alone) and arises from a heterogeneous etiology, with secondary...
Published: 4/8/2024   |   Inventor(s): Derek Leroith
Keywords(s): BAXXXX, IDXXXX, IXXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, ResearchProducts > Animal Models, Application > Diagnostics, Application > Research Materials
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