Search Results - knock-out

3 Results

Sort By:

Novel mouse models of methylmalonic acidemia (MMA) : C57Bl6/Sv129 Mut-/- (full knock-out) and (C57Bl6/Sv129) FvBN Mut -/- (full knock-out)

Methylmalonic acidemia (MMA) is an autosomal recessive disorder caused by the deficiency of the mitochondrial enzyme methylmalonyl-CoA mutase (MUT). It is characterized by metabolic instability, multiorgan pathology, and poor prognosis for long-term survival. To study MMA caused by MUT deficiency, a series of murine models have been constructed using...

Published: 7/25/2024 | Inventor(s): Randy Chandler, Charles Venditti

Keywords(s): -/-, :, Acidemia, C57Bl6/Sv129, FULL, FvBN, KNOCK-OUT, Methylmalonic, MMA, Models, Mouse, MUT, Mut-/-, Novel, VPXXXX, WIXXXX, XEXXXX

Category(s): TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, TherapeuticArea > Ophthalmology, TherapeuticArea > Dental, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Endocrinology, TherapeuticArea > Cardiology

Serotonin-Deficient Knock-out Mouse

Serotonin is an important modulator of many developmental, behavioral, and physiological processes, and it has been implicated in depression, anxiety, schizophrenia, obsessive compulsive disorders, and substance abuse. Serotonin’s pharmacology is extremely complex and it is mediated by seven of serotonin receptor subtypes and it is present in several...

Published: 7/25/2024 | Inventor(s): Dennis Murphy

Keywords(s): AC6XXX, ACXXXX, AXXXXX, KNOCK-OUT, Mouse, MXXXXX, NC4XXX, NCXXXX, NXXXXX, Serotonin-Deficient, VEXXXX, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Neurology, Application > Diagnostics, Application > Research Materials

Tristetraprolin (TTP) Knockout Mice

National Institutes of Health researchers have developed knockout mice that do not express Tristetraprolin (TTP). TTP is an AU-rich element (ARE) binding protein and the prototype of a family of CCCH zinc finger proteins. AREs were identified as conserved sequences found in the 3’ untranslated region (3’ UTR) of a variety of transiently expressed...

Published: 7/25/2024 | Inventor(s): Perry Blackshear

Keywords(s): AC5XXX, ACXXXX, AXXXXX, BAXXXX, CCXXXX, CXXXXX, IDXXXX, IXXXXX, KNOCK-OUT, Mouse, TTP

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Oncology, Application > Research Materials, Application > Therapeutics, Application > Diagnostics, ResearchProducts > Animal Models