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Therapeutic, Bifunctional Janus Microparticles with Spatially Segregated Surface Proteins and Methods of Production
CDC researchers have developed a fabrication process to create bifunctional microparticles displaying two distinct proteins that are spatially segregated onto a single hemispheric surface. At present, there is no described way of producing biological microparticles with two distinct types of separated proteins. Bifunctional Janus particles generated...
Published: 4/8/2024   |   Inventor(s): David White, Jennifer Tang, Todd Sulchek
Keywords(s): AAXXXX, ABXXXX, Asymmetrical, AXXXXX, Bi-Functionalized, CAXXXX, CBXXXX, CCXXXX, CDC Docket Import, CDC Docket Import NP, CXXXXX, DAXXXX, DBXXXX, DDXXXX, DEXXXX, DXXXXX, IAXXXX, IBXXXX, ICXXXX, IXXXXX, Microparticles, PXXXXX, VAXXXX, VBXXXX, VCXXXX, VDXXXX, VEXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VJXXXX, VKXXXX, VLXXXX, VMXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WIXXXX, WJXXXX, WKXXXX, WMXXXX, XAXXXX, XCXXXX, XDXXXX, XFXXXX, XHXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, Application > Consumer Products, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Neurology, TherapeuticArea > Oncology, TherapeuticArea > Dental, Application > Therapeutics, TherapeuticArea > Endocrinology, Application > Vaccines, TherapeuticArea > Immunology, TherapeuticArea > Ophthalmology, TherapeuticArea > Infectious Disease, Application > Software / Apps, TherapeuticArea > Geriatrics, Application > Medical Devices, ResearchProducts > Research Equipment, Application > Diagnostics, ResearchProducts > Antibodies, Application > Research Materials
Rabbit Polyclonal Antibody to Detect a Pro-peptide Fragment of NSAID-activated Gene (NAG-1)/GDF15, a Protein Associated with Cancer
Chronic inflammation is clearly associated with an increase in the risk of cancer. Non-steroidal anti-inflammatory drugs (NSAIDs) are well documented as agents that inhibit tumor growth and with long-term use can prevent tumor development. NSAID-activated gene (NAG-1), a unique member of the TGF-beta superfamily, is highly induced by NSAIDs and numerous...
Published: 7/25/2024   |   Inventor(s): Thomas Eling
Keywords(s): ANTIBODY, CC3AXX, CC3XXX, CCXXXX, CXXXXX, Detection, NAG-1/Gdf15, polyclonal, Pro-peptide, rabbit
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, TherapeuticArea > Oncology
Sirt1 Knockout (Sirt1tm1.1Cxd) Mouse Model for Oncology and Metabolism Studies
Sirt1 knockout: Sirt1, a protein deacetylase, is a tumor suppressor that promotes genome stability and regulates proteins involved in energy metabolism. Yeast Sir2, a nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase, has been implicated in chromatin silencing, longevity and genome stability. Mammals contain a family of related...
Published: 7/25/2024   |   Inventor(s): Chuxia Deng
Keywords(s): CCXXXX, cre-lox, Cre-loxP, CXXXXX, GCXXXX, GXXXXX, IDXXXX, IXXXXX, knockout mice, Mouse, Mouse animal model, SIRT1, Tm1.1Cxd
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, Application > Diagnostics, Application > Research Materials
UTX LoxP Mouse Model for Oncology Research
UTX-flox. Conditional knockout mice for the histone demethylase UTX (Kdm6a) conditional knockout will help understand its role as a tumor suppressor. Di- and tri-methylations on histone H3 lysine 27 (H3K27me2 and H3K27me3) are epigenetic marks for gene repression. UTX (ubiquitously transcribed X chromosome protein), also known as Kdm6a (lysine (K)-specific...
Published: 4/8/2024   |   Inventor(s): Kai Ge
Keywords(s): CCXXXX, CXXXXX, LOXP, Mouse, UTX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Research Materials
Tg(MMTV-Cre)#Mam Mouse Model for Developmental Biology, Hepatology, and Oncology Studies
Cre-recombinase under the control of mouse mammary tumor virus long terminal repeat (MMTV) was expressed in the salivary gland and mammary epithelial cells of adult mice, and induced recombination in all tissues. The Cre recombinase from bacteriophage P1 excises intervening DNA sequences located between two unidirectional lox sites positioned on the...
Published: 7/25/2024   |   Inventor(s): Lothar Hennighausen
Keywords(s): CCXXXX, CXXXXX, IDXXXX, IXXXXX, Mouse, R1XXXX, RXXXXX, TgMMT-Cre#Mam
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Oncology
Stat1LoxP (Stat1 tm1Mam ) Mouse Model for Oncology and Immunology Studies
Selective inactivation of Stat1 in mammary cells indicates that its effect as a tumor suppressor in breast is direct. STAT1 is considered a tumor suppressor, but it is not known if this effect occurs directly in mammary cells or secondarily by disrupting interferon signaling through the JAK/STAT1 pathway to induce immune responses. ERBB2/neu-induced...
Published: 4/8/2024   |   Inventor(s): Lothar Hennighausen
Keywords(s): CCXXXX, CXXXXX, Mouse, STAT1, Stat1LoxP, Tm1Mam
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology
Monoclonal Antibodies Targeting Human DNA Polymerase beta, a DNA Repair Enzyme
Available for licensing are monoclonal antibodies targeting human DNA polymerase beta (Pol B). Pol B is a constitutively expressed "housekeeping" enzyme that plays a role in base excision repair (BER), a cellular defense mechanism that repairs DNA base damage and loss. Aberrant Pol B expression is associated with genomic instability indicating that...
Published: 7/25/2024   |   Inventor(s): Rajendra Prasad, Samuel Wilson
Keywords(s): AC5XXX, ACXXXX, ANTIBODY, AXXXXX, CC2XXX, CCXXXX, CDXXXX, CXXXXX, DNA, DNA polymerase, DNA polymerase beta, monoclonal, Monoclonal Antibody, monoclonal antibody based assays, polymerase
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology
Model Cell Lines With and Without AKT1 Mutations Derived from Proteus Syndrome Patients
The Proteus syndrome is a congenital disorder characterized by patchy overgrowth and hyperplasia (cell proliferation) of multiple tissues and organs, along with susceptibility to developing tumors. It is a rare disorder, with incidence of less than one case per million, caused by a somatic mutation. It is also a mosaic disorder, that is one in which...
Published: 7/25/2024   |   Inventor(s): Marjorie Lindhurst, Leslie Biesecker
Keywords(s): CC3AXX, CCXXXX, CXXXXX, DERIVED, Lines, Patients, Proteus, Single-cell, Syndrome
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Research Materials
Transgenic Human Interleukin-21 Mouse Model
Available for licensing is a mouse model that constitutively expresses human interleukin-21 (IL-21). Traditionally, human IL-21 transgenic mouse models are difficult to produce as those with high IL-21 levels exhibit growth retardation and die before sexual maturity. The investigators generated transgenic mice that express human IL-21, which can stimulate...
Published: 7/25/2024   |   Inventor(s): Katsutoshi Ozaki, Warren Leonard
Keywords(s): AC5XXX, ACXXXX, AXXXXX, CCXXXX, CXXXXX, IDXXXX, IL-21, INTERLEUKIN, interleukin 21, IXXXXX, Mice, Mouse, Mouse animal model, mouse model, TRANSGENIC
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Oncology, Application > Therapeutics
mGluR5 Tumor Mouse Model
Glutamate receptor mGluR5 has been reported to function in the brain. There were no prior reports of it being involved in melanoma. The NIH investigators have discovered that when over expressed in transgenic animals, mGluR5 induces melanoma. The establishment of an mGluR5 tumor mouse model will provide a unique opportunity to help elucidate the mechanisms...
Published: 7/25/2024   |   Inventor(s): Kyu Yeong Choi, Katherine Roche
Keywords(s): CCXXXX, CXXXXX, MGluR5, Model, Mouse, RXXXXX, tumor
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology
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