Search Results - loxp

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Sirt1 LoxP (Sirt1tm1Cxd) Mouse Model for Metabolism and Hepatology Studies

Generation of floxed Sirtuin 1 Exon5-Exon6 for the construction of conditional knockout mice. Sirtuin 1 (Sirt1), a homolog of yeast Sir 2, is an NAD-dependent histone and protein deacetylase. It has a wide range of biological functions, ranging from DNA damage repair to effects on glucose metabolism. Sirt1 null mice die before birth due to chromosomal...

Published: 7/25/2024 | Inventor(s): Chuxia Deng

Keywords(s): 1, IDXXXX, IXXXXX, LOXP, Mouse, Sirt, SIRT1, Tm1Cxd

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics

Sirt6 LoxP (Sirt6tm1.1Cxd) Mouse Model for Liver Studies

Generation of floxed Sirtuin 6 for the construction of conditional knockout mice. The Sirtuins (Sirt1-7), a family of seven proteins related to yeast Sir2, are histone deacetylases that regulate many critical biological processes including genomic stability, adaptation to calorie restriction and aging. Mice with a targeted disruption of Sirt6 had very...

Published: 7/25/2024 | Inventor(s): Chuxia Deng

Keywords(s): IDXXXX, IXXXXX, LOXP, Mouse, Sirt6, Sirt6tm1.1Cxd, Tm1.1Cxd

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics

UTX LoxP Mouse Model for Oncology Research

UTX-flox. Conditional knockout mice for the histone demethylase UTX (Kdm6a) conditional knockout will help understand its role as a tumor suppressor. Di- and tri-methylations on histone H3 lysine 27 (H3K27me2 and H3K27me3) are epigenetic marks for gene repression. UTX (ubiquitously transcribed X chromosome protein), also known as Kdm6a (lysine (K)-specific...

Published: 4/8/2024 | Inventor(s): Kai Ge

Keywords(s): CCXXXX, CXXXXX, LOXP, Mouse, UTX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Research Materials

Gs Alpha LoxP (Gnastm1Lsw) Mouse Model for Metabolism Studies

Generation of a floxed Gnsa gene for the G-protein Gs alpha (Gsalpha) for the construction of conditional knockout mice. The heterotrimeric G protein Gsalpha couples many receptors to adenylyl cyclase and is essential for hormone-stimulated cAMP generation. Previous mouse models with germ-line mutations in Gnas, the gene that encodes Gsalpha had limited...

Published: 7/25/2024 | Inventor(s): Lee Weinstein

Keywords(s): ALPHA, AXXXXX, GCXXXX, Ghas, GS, GXXXXX, LOXP, Mouse, RXXXXX, Tm1LSW

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Therapeutics

Bcl-x LoxP (Bcl2l1 tm1.1Mam) Mouse Model for Developmental Biology Studies

Floxed Bcl-x: Conditional knockout of pro-survival Bcl-x in primordial germ cells was used to study the balance between pro-apoptotic Bax during embryogenesis. Bcl-x is a pro-survival protein that opposes the pro-apoptotic action of Bax which interacts with mitochondria to activate the caspase 9 pathway. Mice in which the Bcl-x gene is inactivated...

Published: 4/8/2024 | Inventor(s): Lothar Hennighausen

Keywords(s): Bcl, Bcl2l1, IDXXXX, IXXXXX, LOXP, Mouse, R1XXXX, RXXXXX, Tm1/Mam

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics

Stat5a LoxP/Stat5b LoxP (Stat5a/Stat5btm2Mam) Mouse Model for Mammopoietic and Lactogenic Signaling Studies

Conditional knockout of Stat5a and Stat5b: Combined deletion of conserved Stat5a and Stat5b in mammary epithelium at different times during pregnancy reveal multiple distinct functions. The signal transducer and activator of transcription (STAT) family of transcription factors conveys signals from membrane receptors to the nucleus, where they activate...

Published: 7/25/2024 | Inventor(s): Lothar Hennighausen

Keywords(s): ACXXXX, AXXXXX, ID1XXX, IDXXXX, IXXXXX, LOXP, LoxP/Stat5b, Mouse, R1XXXX, RXXXXX, STAT5A, Stat5a/Stat5b, Tm2Mam

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials