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A method to label heparan sulfate proteoglycan in the plasma membrane of mammalian cells

Heparan sulfate proteoglycan (HSPG) is a group of lipid-anchored proteoglycans, engaged in a variety of key biological functions on cell surface. HSPG-mediated endocytosis of neurotoxic protein aggregates has been linked to aging related neurodegenerative diseases. Labeling HSPG is a promising technique to trace cell profile in cell research, monitor...

Published: 7/25/2024 | Inventor(s): Qi Zhang, Yihong Ye

Keywords(s): Cells, HEPARAN, Label, MAMMALIAN, MEMBRANE, Method, PLASMA, PROTEOGLYCAN, R1XXXX, SULFATE, XCXXXX

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials

Bcl-x LoxP (Bcl2l1 tm1.1Mam) Mouse Model for Developmental Biology Studies

Floxed Bcl-x: Conditional knockout of pro-survival Bcl-x in primordial germ cells was used to study the balance between pro-apoptotic Bax during embryogenesis. Bcl-x is a pro-survival protein that opposes the pro-apoptotic action of Bax which interacts with mitochondria to activate the caspase 9 pathway. Mice in which the Bcl-x gene is inactivated...

Published: 4/8/2024 | Inventor(s): Lothar Hennighausen

Keywords(s): Bcl, Bcl2l1, IDXXXX, IXXXXX, LOXP, Mouse, R1XXXX, RXXXXX, Tm1/Mam

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics

Stat5a LoxP/Stat5b LoxP (Stat5a/Stat5btm2Mam) Mouse Model for Mammopoietic and Lactogenic Signaling Studies

Conditional knockout of Stat5a and Stat5b: Combined deletion of conserved Stat5a and Stat5b in mammary epithelium at different times during pregnancy reveal multiple distinct functions. The signal transducer and activator of transcription (STAT) family of transcription factors conveys signals from membrane receptors to the nucleus, where they activate...

Published: 7/25/2024 | Inventor(s): Lothar Hennighausen

Keywords(s): ACXXXX, AXXXXX, ID1XXX, IDXXXX, IXXXXX, LOXP, LoxP/Stat5b, Mouse, R1XXXX, RXXXXX, STAT5A, Stat5a/Stat5b, Tm2Mam

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials

Tg(MMTV-Cre)#Mam Mouse Model for Developmental Biology, Hepatology, and Oncology Studies

Cre-recombinase under the control of mouse mammary tumor virus long terminal repeat (MMTV) was expressed in the salivary gland and mammary epithelial cells of adult mice, and induced recombination in all tissues. The Cre recombinase from bacteriophage P1 excises intervening DNA sequences located between two unidirectional lox sites positioned on the...

Published: 7/25/2024 | Inventor(s): Lothar Hennighausen

Keywords(s): CCXXXX, CXXXXX, IDXXXX, IXXXXX, Mouse, R1XXXX, RXXXXX, TgMMT-Cre#Mam

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Oncology

Tg(Wap-cre)11738Mam Mouse Model for Developmental Biology Studies

Cre-recombinase under the control of the whey acidic acid protein was only detected in alveolar epithelial cells of mammary tissue during lactation, and transcription occurred at all stages of mammary development. The Cre recombinase from bacteriophage P1 excises intervening DNA sequences located between two unidirectional lox sites positioned on the...

Published: 4/8/2024 | Inventor(s): Lothar Hennighausen

Keywords(s): Mouse, R1XXXX, RXXXXX, TgWap-cre11738Mam

Category(s): Collaboration Sought > Licensing, Application > Research Materials

Development of Reagents to Examine the Expression and Function of CYP2J Subfamily P450s

Cytochrome P450s catalyze the metabolism of a wide range of exogenous compounds, including drugs, industrial chemicals, environmental pollutants, and carcinogens. The 2C family of cytochrome P450 metabolizes an extensive number of drugs which include tolbutamide, S-Warfarin, mephenytoin, diazepam and taxol. The inventors cloned the cDNAs for several...

Published: 7/25/2024 | Inventor(s): Darryl Zeldin, Jennifer Bradbury

Keywords(s): CYP2J, Development, Examine, Expression, FUNCTION, Listed LPM Contreras as of 4/15/2015, P450s, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, R1XXXX, REAGENTS, RXXXXX, SUBFAMILY

Category(s): Collaboration Sought > Collaboration, Application > Research Materials

Antibodies that Selectively Detect the Human Nestin Protein

Nestin is an intermediate filament protein first described in early embryonic neuroepithelial stem cells. Although not found in most cells of the mature CNS, nestin is the predominant marker used to detect the small population of undifferentiated cells. The presence of nestin identifies stem, progenitor and some tumor cells in the CNS, and also labels...

Published: 7/25/2024 | Inventor(s): Conrad Messam, Eugene Major, Jean Hou

Keywords(s): Antisera, Cross, Human, Listed LPM Maddox as of 4/15/2015, Nestin, polyclonal, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, R1XXXX, rabbit, Reactive, Rodent, RXXXXX, Specific, X

Category(s): Collaboration Sought > Licensing, Application > Research Materials

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