Search Results - lothar+hennighausen

6 Results

Sort By:

Stat5a Knockout (Stat5atm1Mam) Mouse Model for Mammopoietic and Lactogenic Signaling Studies

Stat 5a Knockout: Stat5a deficiency results in the loss of prolactin-dependent mammary gland development and lactogenesis. Prolactin induces mammary gland development and lactogenesis. Binding of Prolactin to its receptor leads to the phosphorylation and activation of STAT (signal transducers and activators of transcription) proteins. Two Stat proteins,...

Published: 7/25/2024 | Inventor(s): Lothar Hennighausen

Keywords(s): GC1XXX, GCXXXX, GXXXXX, ID1XXX, IDXXXX, IXXXXX, Knock, Mouse, RXXXXX, STAT5A, Tm1Mam

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Research Materials, Application > Diagnostics

Bcl-x LoxP (Bcl2l1 tm1.1Mam) Mouse Model for Developmental Biology Studies

Floxed Bcl-x: Conditional knockout of pro-survival Bcl-x in primordial germ cells was used to study the balance between pro-apoptotic Bax during embryogenesis. Bcl-x is a pro-survival protein that opposes the pro-apoptotic action of Bax which interacts with mitochondria to activate the caspase 9 pathway. Mice in which the Bcl-x gene is inactivated...

Published: 4/8/2024 | Inventor(s): Lothar Hennighausen

Keywords(s): Bcl, Bcl2l1, IDXXXX, IXXXXX, LOXP, Mouse, R1XXXX, RXXXXX, Tm1/Mam

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics

Stat5a LoxP/Stat5b LoxP (Stat5a/Stat5btm2Mam) Mouse Model for Mammopoietic and Lactogenic Signaling Studies

Conditional knockout of Stat5a and Stat5b: Combined deletion of conserved Stat5a and Stat5b in mammary epithelium at different times during pregnancy reveal multiple distinct functions. The signal transducer and activator of transcription (STAT) family of transcription factors conveys signals from membrane receptors to the nucleus, where they activate...

Published: 7/25/2024 | Inventor(s): Lothar Hennighausen

Keywords(s): ACXXXX, AXXXXX, ID1XXX, IDXXXX, IXXXXX, LOXP, LoxP/Stat5b, Mouse, R1XXXX, RXXXXX, STAT5A, Stat5a/Stat5b, Tm2Mam

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials

Tg(MMTV-Cre)#Mam Mouse Model for Developmental Biology, Hepatology, and Oncology Studies

Cre-recombinase under the control of mouse mammary tumor virus long terminal repeat (MMTV) was expressed in the salivary gland and mammary epithelial cells of adult mice, and induced recombination in all tissues. The Cre recombinase from bacteriophage P1 excises intervening DNA sequences located between two unidirectional lox sites positioned on the...

Published: 7/25/2024 | Inventor(s): Lothar Hennighausen

Keywords(s): CCXXXX, CXXXXX, IDXXXX, IXXXXX, Mouse, R1XXXX, RXXXXX, TgMMT-Cre#Mam

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Oncology

Tg(Wap-cre)11738Mam Mouse Model for Developmental Biology Studies

Cre-recombinase under the control of the whey acidic acid protein was only detected in alveolar epithelial cells of mammary tissue during lactation, and transcription occurred at all stages of mammary development. The Cre recombinase from bacteriophage P1 excises intervening DNA sequences located between two unidirectional lox sites positioned on the...

Published: 4/8/2024 | Inventor(s): Lothar Hennighausen

Keywords(s): Mouse, R1XXXX, RXXXXX, TgWap-cre11738Mam

Category(s): Collaboration Sought > Licensing, Application > Research Materials

Stat1LoxP (Stat1 tm1Mam ) Mouse Model for Oncology and Immunology Studies

Selective inactivation of Stat1 in mammary cells indicates that its effect as a tumor suppressor in breast is direct. STAT1 is considered a tumor suppressor, but it is not known if this effect occurs directly in mammary cells or secondarily by disrupting interferon signaling through the JAK/STAT1 pathway to induce immune responses. ERBB2/neu-induced...

Published: 4/8/2024 | Inventor(s): Lothar Hennighausen

Keywords(s): CCXXXX, CXXXXX, Mouse, STAT1, Stat1LoxP, Tm1Mam

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology