Search Results - stat5a

2 Results

Sort By:

Stat5a Knockout (Stat5atm1Mam) Mouse Model for Mammopoietic and Lactogenic Signaling Studies

Stat 5a Knockout: Stat5a deficiency results in the loss of prolactin-dependent mammary gland development and lactogenesis. Prolactin induces mammary gland development and lactogenesis. Binding of Prolactin to its receptor leads to the phosphorylation and activation of STAT (signal transducers and activators of transcription) proteins. Two Stat proteins,...

Published: 7/25/2024 | Inventor(s): Lothar Hennighausen

Keywords(s): GC1XXX, GCXXXX, GXXXXX, ID1XXX, IDXXXX, IXXXXX, Knock, Mouse, RXXXXX, STAT5A, Tm1Mam

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Research Materials, Application > Diagnostics

Stat5a LoxP/Stat5b LoxP (Stat5a/Stat5btm2Mam) Mouse Model for Mammopoietic and Lactogenic Signaling Studies

Conditional knockout of Stat5a and Stat5b: Combined deletion of conserved Stat5a and Stat5b in mammary epithelium at different times during pregnancy reveal multiple distinct functions. The signal transducer and activator of transcription (STAT) family of transcription factors conveys signals from membrane receptors to the nucleus, where they activate...

Published: 7/25/2024 | Inventor(s): Lothar Hennighausen

Keywords(s): ACXXXX, AXXXXX, ID1XXX, IDXXXX, IXXXXX, LOXP, LoxP/Stat5b, Mouse, R1XXXX, RXXXXX, STAT5A, Stat5a/Stat5b, Tm2Mam

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials