Search Results - tm1mam

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Stat5a Knockout (Stat5atm1Mam) Mouse Model for Mammopoietic and Lactogenic Signaling Studies

Stat 5a Knockout: Stat5a deficiency results in the loss of prolactin-dependent mammary gland development and lactogenesis. Prolactin induces mammary gland development and lactogenesis. Binding of Prolactin to its receptor leads to the phosphorylation and activation of STAT (signal transducers and activators of transcription) proteins. Two Stat proteins,...

Published: 7/25/2024 | Inventor(s): Lothar Hennighausen

Keywords(s): GC1XXX, GCXXXX, GXXXXX, ID1XXX, IDXXXX, IXXXXX, Knock, Mouse, RXXXXX, STAT5A, Tm1Mam

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Research Materials, Application > Diagnostics

Stat1LoxP (Stat1 tm1Mam ) Mouse Model for Oncology and Immunology Studies

Selective inactivation of Stat1 in mammary cells indicates that its effect as a tumor suppressor in breast is direct. STAT1 is considered a tumor suppressor, but it is not known if this effect occurs directly in mammary cells or secondarily by disrupting interferon signaling through the JAK/STAT1 pathway to induce immune responses. ERBB2/neu-induced...

Published: 4/8/2024 | Inventor(s): Lothar Hennighausen

Keywords(s): CCXXXX, CXXXXX, Mouse, STAT1, Stat1LoxP, Tm1Mam

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology