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Bcl-x LoxP (Bcl2l1 tm1.1Mam) Mouse Model for Developmental Biology Studies

Floxed Bcl-x: Conditional knockout of pro-survival Bcl-x in primordial germ cells was used to study the balance between pro-apoptotic Bax during embryogenesis. Bcl-x is a pro-survival protein that opposes the pro-apoptotic action of Bax which interacts with mitochondria to activate the caspase 9 pathway. Mice in which the Bcl-x gene is inactivated...

Published: 4/8/2024 | Inventor(s): Lothar Hennighausen

Keywords(s): Bcl, Bcl2l1, IDXXXX, IXXXXX, LOXP, Mouse, R1XXXX, RXXXXX, Tm1/Mam

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics