Search Results - expression

17 Results

Sort By:

Stopping Neurogenesis in Transgenic Mice and Rat Models that Express the HSV-thymidine kinase Gene in Neuronal Precursor Cells

This invention relates to novel mouse and rat models that permit the temporal death of neuronal precursor cells at any time point. Other existing methods of decreasing neurogenesis are relatively non-specific (e.g., injecting glucocorticoids) or require expensive equipment (e.g., focal x-irradiation) These mice and rats are being used to inhibit adult...

Published: 7/25/2024 | Inventor(s): James Pickel, Heather Cameron

Keywords(s): Driving, Expression, GFAP, HSV, Kinase, Listed LPM Maddox as of 4/15/2015, Mice, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PROMOTER, RATS, Thymidine, TRANSGENIC, VEXXXX, WIXXXX, XEXXXX

Category(s): Application > Therapeutics, TherapeuticArea > Neurology, Application > Research Materials

Discovery of Proteasome Inhibitors to Target PMP22 Gene Expression for the Treatment of Charcot-Marie-Tooth Disease Type 1A

This technology includes the use of proteasome inhibitors, such as Bortezomib, for the treatment of the most prevalent form of Charcot-Marie-Tooth disease type 1A (CMT1A). Duplication of the peripheral myelin protein 22 (PMP22) gene, normally involved in myelination of the peripheral nervous system, is the causative agent in most forms of CMT1A. A drug...

Published: 7/25/2024 | Inventor(s): Sung-Wook Jang, John Svaren, James Inglese

Keywords(s): Discovery, DOWN, Expression, Gene, inhibition, Listed LPM Tong as of 4/15/2015, MEANS, Pmp22, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Proteasome, REGULATE, VEXXXX, WKXXXX, XEXXXX

Category(s): Application > Therapeutics, TherapeuticArea > Neurology

A Cell Line that Expresses secNluc and GFP to Recapitulate PMP22 Gene Expression for Studying Peripheral Neuropathy

This technology includes a cell line that expresses two reporters (a secreted luciferase, secNLuc, and GFP) in a pattern that recapitulates the endogenous expression of the peripheral myelin protein 22 (Pmp22) gene. Pmp22 is mainly expressed in the Schwann cells of the peripheral nervous system. Many neurological disorders are associated with aberrations...

Published: 7/25/2024 | Inventor(s): John Svaren, Sung-Wook Jang, James Inglese

Keywords(s): Cell, Coincidence, ENDOGENOUS, ENGINEERED, Express, Expression, Gene, GENETICALLY, GFP, Line, Listed LPM Tong as of 4/15/2015, LOCUS, Pmp22, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Recapitulate, Reporters, SecNluc, That, VEXXXX, WIXXXX, XEXXXX

Category(s): Application > Therapeutics, TherapeuticArea > Neurology, Application > Research Materials

Recombinant Chimeric Bovine/Human Parainfluenza Virus 3 Expressing SARS-CoV-2 Spike Protein and Its Use

Vaccines for SARS-CoV-2 are increasingly available under emergency use authorizations; however, indications are currently limited to individuals twelve (12) years or older. They also involve intramuscular immunization, which does not directly stimulate local immunity in the respiratory tract, the primary site of SARS-CoV-2 infection, shedding and spread....

Published: 7/25/2024 | Inventor(s): Shirin Munir, Cindy Luongo, Peter Collins, Cyril Le Nouen, Xueqiao Liu, Ursula Buchholz

Keywords(s): 2, ACUTE, Attenuated, B/HPIV3, BOVINE/HUMAN, chimeric, CORONAVIRUS, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DEXXXX, DXXXXX, Expression, GLYCOPROTEIN, PIV3, respiratory, S, SARS-CoV-2, SEVERE, spike, Syndrome

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Research Materials

Expression, Purification, and Validation of Anthrax Toxin Proteins

Expression, purification, and validation of anthrax toxin proteins.

Published: 7/25/2024 | Inventor(s): Rasem Fattah, Stephen Leppla

Keywords(s): Anthrax, Expression, proteins, purification, RM, toxin, Validation, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials

A Novel Virus-Based Expression System

The present invention is related to a recombinant viral vector for vaccines. Currently available poxvirus vectors for humans and other animals exhibit suboptimal expression of recombinant gene(s) and high expression of vector proteins which causes weak immunogenicity and high anti-vector immune response. The present novel virus-based expression vectors...

Published: 7/25/2024 | Inventor(s): Linda Wyatt, Bernard Moss

Keywords(s): Expression, Gene, GENES, High, LOW, Non-Replicating, System, TARGET, vaccinia, Vector, virus, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WIXXXX, WNXXXX, XEXXXX, YAXXXX, YBXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Therapeutics

Diagnostic Test and Therapeutic Target for Sjogren's Syndrome

Sjögren's syndrome is an autoimmune disease that attacks salivary glands resulting in chronic dry mouth and dry eyes. Currently, there is no single diagnostic test to confirm the presence of Sjögren's. Physicians presently reach diagnosis after conducting a series of blood and functional tests for tear and salivary production. Diagnosis is further...

Published: 7/25/2024 | Inventor(s): Melodie Weller, Hongen Yin, John (Jay) Chiorini

Keywords(s): Alteration, BMP6, Detection, Diagnosis, Expression, Gland, IA3XXX, IAXXXX, IXXXXX, LEVELS, Listed LPM Contreras as of 4/15/2015, Locally, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Salivary, Sjogren's, Syndrome, treatment

Category(s): TherapeuticArea > Immunology, Application > Diagnostics, Application > Research Materials, Application > Therapeutics

Adeno-Associated Virus Gene Therapy for Diabetes and Obesity

This invention is directed to adeno-associated virus (AAV) vector delivery of exendin-4 (Ex-4) to salivary glands as treatment for diabetes and obesity. Ex-4 is a potent and long-acting agonist of the receptor for glucagon-like peptide 1 (GLP-1). Scientists at NIDCR have shown that AAV-mediated delivery of Ex-4 resulted in improved glucose homeostasis...

Published: 7/25/2024 | Inventor(s): Giovanni Di Pasquale, Edward Mannucci, John (Jay) Chiorini

Keywords(s): DIABETES, EPITHELIA, Expression, Fusion, GBXXXX, Gland, IBXXXX, Listed LPM Contreras as of 4/15/2015, NGF/exendin-4, Novel, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Protein, Salivary, treatment

Category(s): Application > Therapeutics

Human DNA Polymerase Gamma for Testing the Effect of Drugs on Mitochondrial Function

One of the primary means for treating HIV infection is the use of antiviral nucleotide or nucleoside analogs. These analogs work by inhibiting the activity of reverse transcriptase, the enzyme responsible for preparing the HIV genome for integration into the DNA of the host cell. Although these analogs do not have an effect on the polymerases responsible...

Published: 7/25/2024 | Inventor(s): Rajesh Kasiviswanathan, Susan Lim, William Copeland

Keywords(s): CLONE, DDXXXX, DEFICIENT, Directed, DNA, DXXXXX, Enzyme, EXONUCLEASE, Expression, Gamma, Human, Improved, Includes, Listed LPM Campbell as of 4/15/2015, Method, Modifications, polymerase, Polymerase., Post LPM Assignment Set 20150420, Pre LPM working set 20150418, purification, recombinant, RXXXXX, SITE, TYPE, VLXXXX, Which, Wild, WIXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics

Construct for Tetracycline Inducible Podocyte Specific Gene Expression in Mice

The National Institutes of Health announces the generation of a construct by ligating 2.5kb human podocin promoter sequence to gene encoding reverse tetracycline-controlled transcriptional activator which enables tetracycline-inducible podocyte specific gene of interest expression with another construct consisting of tetracycline responsive element,...

Published: 7/25/2024 | Inventor(s): Jeffrey Kopp

Keywords(s): CONSTRUCT, Expression, Gene, IDXXXX, INDUCIBLE, IXXXXX, Mice, Podocyte, Specific, Tetracycline

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics

1 2