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Human DNA Polymerase Gamma for Testing the Effect of Drugs on Mitochondrial Function

One of the primary means for treating HIV infection is the use of antiviral nucleotide or nucleoside analogs. These analogs work by inhibiting the activity of reverse transcriptase, the enzyme responsible for preparing the HIV genome for integration into the DNA of the host cell. Although these analogs do not have an effect on the polymerases responsible...

Published: 7/25/2024 | Inventor(s): Rajesh Kasiviswanathan, Susan Lim, William Copeland

Keywords(s): CLONE, DDXXXX, DEFICIENT, Directed, DNA, DXXXXX, Enzyme, EXONUCLEASE, Expression, Gamma, Human, Improved, Includes, Listed LPM Campbell as of 4/15/2015, Method, Modifications, polymerase, Polymerase., Post LPM Assignment Set 20150420, Pre LPM working set 20150418, purification, recombinant, RXXXXX, SITE, TYPE, VLXXXX, Which, Wild, WIXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics

Polyclonal Antibodies for the Gbeta5-associated Regulator of G Protein Signaling Protein, RGS7

Researchers at NIDDK have developed polyclonal antibodies against the Regulator of G Protein Signalling (RGS) protein, RGS7. RGS7 binds tightly to Gbeta5, a unique and highly specialized G protein that exhibits much less homology than other Gbeta isoforms (~50%). RGS7 is preferentially expressed in brain and neuroendocrine tissue. Like Gbeta5, RGS7...

Published: 7/25/2024 | Inventor(s): Jianhua Zhang, William Simonds

Keywords(s): antibodies, BOVINE, box, Fusion, GST, Includes, Protein, Region, RGS, RGS7, RXXXXX, That

Category(s): Collaboration Sought > Licensing, Application > Research Materials