Search Results - gamma

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Human DNA Polymerase Gamma for Testing the Effect of Drugs on Mitochondrial Function

One of the primary means for treating HIV infection is the use of antiviral nucleotide or nucleoside analogs. These analogs work by inhibiting the activity of reverse transcriptase, the enzyme responsible for preparing the HIV genome for integration into the DNA of the host cell. Although these analogs do not have an effect on the polymerases responsible...

Published: 7/25/2024 | Inventor(s): Rajesh Kasiviswanathan, Susan Lim, William Copeland

Keywords(s): CLONE, DDXXXX, DEFICIENT, Directed, DNA, DXXXXX, Enzyme, EXONUCLEASE, Expression, Gamma, Human, Improved, Includes, Listed LPM Campbell as of 4/15/2015, Method, Modifications, polymerase, Polymerase., Post LPM Assignment Set 20150420, Pre LPM working set 20150418, purification, recombinant, RXXXXX, SITE, TYPE, VLXXXX, Which, Wild, WIXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics

The estrogen-related receptor alpha (ERRalpha) and proliferator-activated-receptor-gamma coactivator-1alpha (PGC-1alpha) play major roles in transcriptional control of cellular energy metabolism. In particular ERRs are required for the response to various environmental challenges that require high energy levels by the organism. As central regulators...

Published: 7/25/2024 | Inventor(s): Negin Martin, Christina Teng

Keywords(s): \Related, Cell, COACTIVATOR, ERR, estrogen, Gamma, Lines, PGC/ERR, Proliferator-activated, RECEPTOR, RELATED, -related, REPORTER, STABLE, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials

Therapeutic Methods Based on In Vivo Modulation of the Production of Interferon gamma

The technology offered for licensing is in the field of Therapeutics. More specifically, the technology relates to biological ligands and their use as modulators of the production of Interferon gamma as a means to treat a broad spectrum of diseases. The invention describes and claims antibodies and other ligands that can stimulate Natural Killer (NK)...

Published: 7/25/2024 | Inventor(s): Sumati (Sumi) Rajagopalan, Eric Long

Keywords(s): Against, antibodies, DB3XXX, DB4XXX, DBXXXX, DC1XXX, DCXXXX, Directed, DXXXXX, Gamma, INTERFERON, KIR2DL4, LIGANDS, Patent Category - Biotechnology, production, RECEPTOR

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Vaccines